1999
DOI: 10.1038/sj.onc.1202661
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BAG-1 accelerates cell motility of human gastric cancer cells

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Cited by 47 publications
(26 citation statements)
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References 28 publications
(35 reference statements)
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“…[60][61][62][63][64][65][66][67][68][69] The functional diversity of BAG domain proteins is paralleled by an abundance of genes of this family throughout evolution, with homologs identified in a variety of organisms, including yeast, worm, invertebrates, amphibians, mammals, and plants. 21,59,60,70 Database searches indicate the presence of eight genes that encode proteins with the BAG domain in Arabidopsis thaliana.…”
Section: Discussionmentioning
confidence: 99%
“…[60][61][62][63][64][65][66][67][68][69] The functional diversity of BAG domain proteins is paralleled by an abundance of genes of this family throughout evolution, with homologs identified in a variety of organisms, including yeast, worm, invertebrates, amphibians, mammals, and plants. 21,59,60,70 Database searches indicate the presence of eight genes that encode proteins with the BAG domain in Arabidopsis thaliana.…”
Section: Discussionmentioning
confidence: 99%
“…BAG-1 is an important regulatory protein that has been shown to have a variety of binding partners and a range of bioactivities, including protection from apoptotic signals (11,19), enhancement of cell motility (20) and regulation of transcription (21,22). BAG-1 has been reported to bind the cytoplasmic domain of the HGF receptor (14), the Raf-1 kinase (23), and several members of the steroid hormone receptor superfamily (21,24), and to be capable of altering the activity of these molecules.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, the nuclear expression of BAG-1 was impressively correlated with the malignant potential in colorectal cancer. BAG-1 has been reported to facilitate epithelial cell survival following detachment from the underlying extracellular matrix (Ruoslahti, 1996;Weaver et al, 1996) and to promote cell migration in human gastric cancer cells (Naishiro et al, 1999). These functions could contribute to the development of distant metastases in malignant tumours since the overexpression of BAG-1 in melanoma cells increases the metastatic potential of these tumour cells (Takaoka et al, 1997).…”
Section: Molecular and Cellular Pathologymentioning
confidence: 99%