Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes

Lacey, Ernest; Gill, Jennifer H.; Power, Michelle; Rickards, Rodney W.; O’Shea, Michael G.; Rothschild, Jennifer M.

doi:10.1016/0020-7519(94)00082-y

Cited by 19 publications

(11 citation statements)

References 14 publications

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“…Specifically in relation to Streptomyces, Lacey et al (1995), for example, demonstrated that bafilomycins and leucanicidins obtained from Streptomyces isolate A239 and A223/A240, respectively, exhibited a broad-spectrum nematicidal activity, being equi-potent as inhibitors of development of Haemonchus contortus, Trichostrongylus colubriformis and Ostertagia circumcincta. Similarly, Jayakumar (2009) reported that culture filtrates of Streptomyces avermitilis isolates significantly inhibited hatching of Meloidogyne incognita compared with hatch in distilled water.…”

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confidence: 98%

Effects on Meloidogyne incognita of chitinase, glucanase and a secondary metabolite from Streptomyces cacaoi GY525

Yoon

Lee

et al. 2012

Nematol

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Streptomyces cacaoi GY525, isolated from liquid compost containing crab shell powder, produced a secondary metabolite 3-benzyl-1,4-diaza-2,5-dioxobicyclo[4.3.0]nonane (BDDB) and lytic enzymes including chitinase and β-1,3-glucanase. To examine the effect of the bacterial culture filtrate (CF) and BDDB on mortality of second-stage juvenile (J2) and hatch inhibition of Meloidogyne incognita, different concentrations of them were added in 24-well plates containing ca 250 eggs and 250 J2, respectively. With increasing concentrations of CF and BDDB mortality of J2 increased while hatch decreased. In pot trials, tomato plants were treated with the GY525 culture (SC), culture medium (CM), commercial nematicide (5% ethoprophos) (CN) and combination of CN and SC (CN + SC). Tap water (TW) was used as a control. During the experimental periods, growth of tomato plants treated with SC markedly increased compared with TW and CN treatments. After 7 weeks the number of egg masses in TW was over 220, while that in SC was around 40 per plant. Population of J2 in soil and the number of egg masses in plant roots in SC, CN + SC and CN were significantly lower than those in TW and CM. Our results suggest that S. cacaoi GY525 has potential as a biological control agent against root-knot nematodes.

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confidence: 98%

Effects on Meloidogyne incognita of chitinase, glucanase and a secondary metabolite from Streptomyces cacaoi GY525

Yoon

Lee

et al. 2012

Nematol

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“…Numerous actinomycetes are known as antagonists of plant‐parasite nematodes and have the ability to produce antibiotics and enzymes, making them highly likely to be applied to biological control. The production of abamectin, now known as a B. xylophilus control compound was derived from actinomycetes 39–41 . Therefore, in this study, we tried to find a natural compound capable of inhibiting B. xylophilus from pine endophytic actinomycetes.…”

Section: Discussionmentioning

confidence: 99%

Nematicidal activity of teleocidin B4 isolated from Streptomyces sp. against pine wood nematode, Bursaphelenchus xylophilus

Kang

Kim

Liu

et al. 2021

Pest Management Science

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BACKGROUND Pine wilt disease (PWD) is a plant disease that causes serious damage to pine trees. PWD occurs when the host plant is infected with pinewood nematode (PWN), Bursaphelenchus xylophilus. In this study, a compound with nematicidal activity was isolated from actinomycetes and its efficacy was investigated in vitro. RESULT We screened and selected Streptomyces sp. 680560, which had nematicidal activity against B. xylophilus. Based on 16S rRNA sequence analysis, it showed 99.93% similarity with Streptomyces blastmyceticus NRRB‐5480T. Furthermore, the active compound was isolated and identified as teleocidin B4. Teleocidin B4 at concentrations ranging from 6.25 to 100 μM had low nematicidal activity after 24 and 36 h against adult and stage juveniles (J2) of B. xylophilus, but after 48 h nematicidal activity exceeded 95%. The rate of inhibition of egg hatching for Teleocidin B4 6.25, 12.5, 25, 50, and 100 μM was confirmed to be dose‐dependently inhibited after 48 h of treatment. Teleocidin B4 is not only toxic to hatched B. xylophilus, but also affects egg hatching. CONCLUSION This study was carried out to isolate actinomycete metabolites from pine tree endophytes from various natural environments for control of PWD. A compound with nematicidal activity was isolated from a selected strain and its structure was identified as teleocidin B4. The nematicidal effect of the isolated active substance, teleocidin B4, was confirmed. This is the first report of the effect of teleocidin B4 on B. xylophilus, suggesting its possibility as a PWD control agent. © 2020 Society of Chemical Industry

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“…Two antibiotics containing the sugar leucanicidin 165 and 19-O-methylleucanicidin 166 are potent inhibitors of larval development in the parasitic nematode Haemonchus contortus (226), and they have been isolated from Streptomyces isolates A233, A239, and A240.…”

Section: -Membered Ring Macrolidesmentioning

confidence: 99%

Astonishing diversity of natural surfactants: 2. Polyether glycosidic ionophores and macrocyclic glycosides

Dembitsky

2005

Lipids

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Polyether glycosidic ionophores and macrocyclic glycosides are of great interest, especially for the medicinal and pharmaceutical industries. These biologically active natural surfactants are good prospects for the future chemical preparation of compounds useful as antibiotics, anticancer agents, or in industry. More than 300 interesting and unusual natural surfactants are described in this review article, including their chemical structures and biological activities.

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Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes

Cited by 19 publications

References 14 publications

Effects on Meloidogyne incognita of chitinase, glucanase and a secondary metabolite from Streptomyces cacaoi GY525

Effects on Meloidogyne incognita of chitinase, glucanase and a secondary metabolite from Streptomyces cacaoi GY525

Nematicidal activity of teleocidin B4 isolated from Streptomyces sp. against pine wood nematode, Bursaphelenchus xylophilus

Astonishing diversity of natural surfactants: 2. Polyether glycosidic ionophores and macrocyclic glycosides

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