Baculovirus-transduced, VEGF-expressing adipose-derived stem cell sheet for the treatment of myocardium infarction

Yeh, Tsung Szu; Fang, Yiqun; Lu, Chia Hsin; Chiu, Shao Chieh; Yeh, Chia Lin; Yen, Tzu Chen; Parfyonova, Y.; Hu, Yu

doi:10.1016/j.biomaterials.2013.09.080

Cited by 62 publications

(68 citation statements)

References 47 publications

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“…Bolli et al infused autologous CSCs to patients with ischemic cardiomyopathy and found that CSCs are effective in improving LV systolic function and reducing infarct size [17] which was consistent with several other reports [18–21]. Furthermore, CSCs can be attracted by cytokines especially growth factors to migrate into the infarct area [22–24]. But the source of these factors and their exact role remains unclear.…”

Section: Discussionsupporting

confidence: 59%

Matrix Metalloproteinase 9 Secreted by Hypoxia Cardiac Fibroblasts Triggers Cardiac Stem Cell Migration In Vitro

Gao

Guo

Zeng

et al. 2015

Stem Cells International

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Cessation of blood supply due to myocardial infarction (MI) leads to complicated pathological alteration in the affected regions. Cardiac stem cells (CSCs) migration plays a major role in promoting recovery of cardiac function and protecting cardiomyocytes in post-MI remodeling. Despite being the most abundant cell type in the mammalian heart, cardiac fibroblasts (CFs) were underestimated in the mechanism of CSCs migration. Our objective in this study is therefore to investigate the migration related factors secreted by hypoxia CFs in vitro and the degree that they contribute to CSCs migration. We found that supernatant from hypoxia induced CFs could accelerate CSCs migration. Four migration-related cytokines were reported upregulated both in mRNA and protein levels. Upon adding antagonists of these cytokines, the number of migration cells significantly declined. When the cocktail antagonists of all above four cytokines were added, the migration cells number reduced to the minimum level. Besides, MMP-9 had an important effect on triggering CSCs migration. As shown in our results, MMP-9 induced CSCs migration and the underlying mechanism might involve TNF-α signaling which induced VEGF and MMP-9 expression.

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Section: Discussionsupporting

confidence: 59%

Matrix Metalloproteinase 9 Secreted by Hypoxia Cardiac Fibroblasts Triggers Cardiac Stem Cell Migration In Vitro

Gao

Guo

Zeng

et al. 2015

Stem Cells International

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“…Better organized infarcts, with a smaller proportion of granulation tissue, found in this study in rats postconditioned by isoflurane could be a consequence of the positive effect that isoflurane had on the number of progenitor cells and blood vessels found in the subacute phase of infarct healing [7]. As we mentioned earlier [29,30], early formation of highly vascularized granulation tissue is probably the main cause of improved healing.…”

Section: Discussionmentioning

confidence: 85%

“…Formation of microvasculature in an infarct is crucial for the supply of nutrients and oxygen and, consequently, for tissue regeneration [20]. In addition, supporting vessel formation (for instance, by implantation of progenitor cells as well as by increased expression of proangiogenic factors) results in decreased infarct size, improved infarct healing, and augmented cardiac function after experimental myocardial damage [29,30].…”

Section: Discussionmentioning

confidence: 99%

Effects of isoflurane postconditioning on chronic phase of ischemia–reperfusion heart injury in rats

Agnić

Filipović

Vukojević

et al. 2015

Cardiovascular Pathology

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“…Our group's experience with viral vectors expressing VEGF165 suggested robust increase of angiogenesis in MI and limb ischemia after delivery of sheets from AD-MSC expressing VEGF165 after viral transduction [114,116]. Efect of these constructs was superior to control CS and we observed no changes in immune response to genetically modiied sheets or cell proliferation/viability within them [114].…”

Section: Cell Sheets: Minimal Tissue-engineered Constructsmentioning

confidence: 95%

Therapeutic Angiogenesis: Foundations and Practical Application

Макаревич¹,

Parfyonova²

2017

Physiologic and Pathologic Angiogenesis - Signaling Mechanisms and Targeted Therapy

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Angiogenesis as therapeutic target has emerged since early works by Judah Folkman, yet his "holy grail" was inhibiting vascular growth to block tumor nutrition. However, in modern biomedicine, "therapeutic angiogenesis" became a large ield focusing on stimulation of blood vessel growth for ischemia relief to reduce its detrimental efects in the tissues. In this review, we introduce basic principles of tissue vascularization in response to ischemia exploited in this ield. An overview of recent status in therapeutic angiogenesis is given with introduction to emerging technologies, including gene therapy, genetic modiication of cells ex vivo and tissue engineering.

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Baculovirus-transduced, VEGF-expressing adipose-derived stem cell sheet for the treatment of myocardium infarction

Cited by 62 publications

References 47 publications

Matrix Metalloproteinase 9 Secreted by Hypoxia Cardiac Fibroblasts Triggers Cardiac Stem Cell Migration In Vitro

Matrix Metalloproteinase 9 Secreted by Hypoxia Cardiac Fibroblasts Triggers Cardiac Stem Cell Migration In Vitro

Effects of isoflurane postconditioning on chronic phase of ischemia–reperfusion heart injury in rats

Therapeutic Angiogenesis: Foundations and Practical Application

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