Bacteriuria With a Multiply Resistant Species of Corynebacterium (Corynebacterium Group D2): An Unnoticed Cause of Urinary Tract Infection

Aguado, José María; Ponte, Carmen; Soriano, Francisco

doi:10.1016/s0022-5347(17)43683-4

Cited by 16 publications

(43 citation statements)

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“…A case of "diphtheroid" pneumonia caused by group D-2 was described in 1979 (94), but it was not until 1985 that the major pathogenic role of this species was defined. In a series of studies from Madrid, Spain (1,179,200,201), this microorganism was associated with urinary tract infections, particularly with alkalineencrusted cystitis. This chronic inflammatory condition of the bladder is accompanied by localized ulcerations with deposits of ammonium magnesium phosphate (struvite).…”

Section: Introductionmentioning

confidence: 99%

“…This chronic inflammatory condition of the bladder is accompanied by localized ulcerations with deposits of ammonium magnesium phosphate (struvite). It has been associated with infections due to urea-spitting microorganisms, such as Proteus spp., in patients whose bladder was already affected by an inflammatory or neoplastic condition, i.e., providing "vesicular ground" (1).…”

Section: Introductionmentioning

confidence: 99%

“…After treatment, the pH of the urine returned to the normal range and struvite crystals disappeared. Both clinical and experimental data (201) Coryneform group D-2 urinary tract infections may be hospital acquired (1,64). This organism is found on healthy skin of 25 to 37% of hospitalized patients (204).…”

Section: Introductionmentioning

confidence: 99%

“…This organism is found on healthy skin of 25 to 37% of hospitalized patients (204). One can speculate that group D-2 colonizes the skin, perhaps in the setting of recent antimicrobial treatment, and after urological instrumentation gains access from the skin to the urinary tract (154), where its urease activity causes alkalinization of the urine, leading to the formation of struvite stones in some patients (1). Since this organism may be missed by conventional urine culture techniques, it should be specifically sought by prolonged (24-to 48-h) incubation on blood or cysteine-lactose-electrolyte-deficient agars.…”

Section: Introductionmentioning

confidence: 99%

“…These organisms have been found to be highly resistant to antimicrobial agents, including nitrofurantoin, trimethoprimsulfamethoxazole, ampicillin, cephalothin, and gentamicin, i.e., those agents commonly used to treat urinary tract infections (1,179,203,226). They are, however, uniformly susceptible to vancomycin and the quinolones (e.g., ciprofloxacin and ofloxcin) and often susceptible to erythromycin, rifampin, novobiocin, and tetracyclines (64,134 (28,244) and meningitis (15,40).…”

Section: Introductionmentioning

confidence: 99%

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Coryneform bacteria in infectious diseases: clinical and laboratory aspects

1990

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Coryneform isolates from clinical specimens frequently cannot be identified by either reference laboratories or research laboratories. Many of these organisms are skin flora that belong to a large number of taxonomic groups, only 40% of which are in the genus Corynebacterium. This review provides an update on clinical presentations, microbiological features, and pathogenic mechanisms of infections with nondiphtheria Corynebacterium species and other pleomorphic gram-positive rods. The early literature is also reviewed for a few coryneforms, especially those whose roles as pathogens are controversial. Recognition of newly emerging opportunistic coryneforms is dependent on sound identification schemes which cannot be developed until cell wall analyses and nucleic acid studies have defined the taxonomic groups and all of the reference strains within each taxon have been shown by molecular methods to be authentic members. Only then can reliable batteries of biochemical tests be selected for distinguishing each taxon.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Coryneform bacteria in infectious diseases: clinical and laboratory aspects

1990

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Adherence and hemagglutination ofCorynebacterium group D2

Marty¹,

Agueda²,

Lapchine³

et al. 1991

Eur. J. Clin. Microbiol. Infect. Dis.

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Sixty-one strains of Corynebacterium group D2 were examined for their ability to adhere to human uroepithelial cells and to agglutinate human and guinea-pig erythrocytes. Strains were isolated from samples of two origins: urine of bacteriuric patients and healthy skin of patients without urinary infection. In addition, the isolates were examined by scanning and transmission electron microscopy. Heavy adherence to the uroepithelial cells but weak hemagglutination were noted. No statistical association was demonstrated between the adherence and the origin of the strains (65.2% of urinary isolates and 80% of healthy skin isolates were adherent). On transmission electron microscopy, a close association was observed between adherent bacteria and cells on thin sections and only few strains were piliated with negative staining. These results do not support a role of adherence as a predictor of pathogenicity of Corynebacterium group D2 which seems to act as an opportunistic pathogen in urinary tract infections.

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Incidence and characteristics of urinary tract infections caused byCorynebacterium urealyticum (Corynebacterium group D2)

Nebreda-Mayoral¹,

Muñoz‐Bellido

Garcı́a-Rodrı́guez

1994

Eur. J. Clin. Microbiol. Infect. Dis.

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The incidence and characteristics of urinary tract infections caused by Corynebacterium urealyticum were studied prospectively in 20,766 urine samples. Corynebacterium urealyticum was isolated from 67 samples (0.32%). Twenty-four percent of the patients from whom Corynebacterium urealyticum was isolated showed mild symptoms and had no risk factors other than prolonged hospitalization and previous antibiotic treatment. Sixty percent of the patients had urinary tract-related symptoms. The main risk factors were underlying urinary tract disease, antibiotic treatment, prolonged hospitalization and urological manipulation. Patients with antimicrobial treatment had a favourable clinical course, with the exception of two patients with encrusted cystitis.

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Bacteriuria With a Multiply Resistant Species of Corynebacterium (Corynebacterium Group D2): An Unnoticed Cause of Urinary Tract Infection

Cited by 16 publications

References 0 publications

Coryneform bacteria in infectious diseases: clinical and laboratory aspects

Coryneform bacteria in infectious diseases: clinical and laboratory aspects

Adherence and hemagglutination ofCorynebacterium group D2

Incidence and characteristics of urinary tract infections caused byCorynebacterium urealyticum (Corynebacterium group D2)

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