Bacteriostats. IV. 1 ι-Amino Acid Amide Derivatives

Twenty‐seven fatty acid derivatives having both the amide and ester functions were screened for antimicrobial activity against a gram‐positive bacterium,Staphylococcus aureus; a gram‐negative bacterium,Escherichia coli; a mold, eitherAspergillus flavus orA. species; and a yeast, eitherCandida albicans orTorula species. All of the compounds effectively inhibited at least one of the organisms, and 19 of them were inhibitory against 3 or more. These 27 compounds were derivatives of diethanolamine or of N‐methylethanolamine. The amide acyl moieties included the lauroyl, palmitoyl, oleoyl, erucoyl, benzoyl, andp‐toluoyl groupings. The ester moieties included the lauroyl, palmitoyl, oleoyl, erucoyl, trimethylacetyl, benzoyl,p‐toluoyl, and furoyl groupings. The activity exhibited by many of these materials suggests that they may have potential utility as biostatic additives in commercial products.

Section: Introductionmentioning

confidence: 99%

Antimicrobial properties of some fatty ester‐amides

Bailey

Boudreaux

Sumrell

et al. 1978

“…Many long chain fatty acid derivatives, particularly Nsubstituted amides, possess antimicrobial activity (1)(2)(3)(4)(5), as do some of the free acids and simple fatty esters (6,7). The availability of a group of diesters of aliphatic diols prepared for use in other research (8) gave us a unique opportunity to investigate the antimicrobial activity 6f these compounds.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial properties of some mixed diesters of aliphatic diols

Bailey

Boudreaux

Sumrell

et al. 1976

Twenty compounds, diesters of ethylene glycol, diethylene glycol, or cis-2-butene-l,4-diol, were screened for antimicrobial activity against a grampositive bacterium, Staphylococcus aureus; a gramnegative bacterium, Escherichia coli; a mold, either AspergHlus flavus or A. species; and a yeast, either Candida albicans or Torula species. All of the compounds were inhibitory against two or more of the test organisms, and eight mixed diesters were inhibitory against all four types of organisms. Each of these eight compounds had a benzoate group at one ester function and an acyl group other than benzoyl, mostly fatty acyl groups of 12-22 carbons, at the other.

Antimicrobial activity and physical characteristics of some N,N‐Disubstituted decanamides

Novak

Solar

Mod

et al. 1969

A number of N,N‐disubstituted decanamides have been prepared, characterized and screened for their antimicrobial activity against a number of pathogenic organisms including bacteria both gram positive and negative, yeasts and molds. Several of these compounds exhibited a broad spectrum and high level of activity against all or most of the test organisms. The antimicrobial activity of these compounds has been shown to correlate with their dispersibility and surface tension in an aqueous systems.