Bacteriostats. II.<sup>1</sup> The Chemical and Bacteriostatic Properties of Isothiocyanates and their Derivatives

McKay, A. F.; Garmaise, D. L.; Gaudry, Roger; Baker, H. A.; Paris, G. Y.; Kay, R. W.; Just, George; Schwartz, Robert N.

doi:10.1021/ja01525a057

Cited by 57 publications

(20 citation statements)

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“…Glenn, Chew & Williams (1985 examined the effects of Brassica species with varying glucosinolate levels on VAM fungus interactions and found no clear relationship between glucosinolate concentrations and the development of VAM fungi. While glucosinolates themselves appear to be non-toxic (Holley & Jones, 1985;Mithen, Lewis & Fenwick, 1986;Vierheilig & Ocampo, 1990), isothiocyanates, produced by the action of myrosinase on glucosinolates, are toxic to a variety of organisms (Walker, Morell & Foster, 1937;McKay et al, 1959;Larsen, 1981). It is clear that extracts from mustard plants are inhibitory to VAM fungi (Ocampo, Cardona & El-Atrach, 1986;Schreiner & Koide, 1992).…”

Section: Introductionmentioning

confidence: 99%

Mustards, mustard oils and mycorrhizas

1993

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Intact, living roots of Brassica kaber (DC.) Wheeler and Brassica nigra. L. (Brassicaceae) were inhibitory to the germination of spores of the mycorrhizal fungi Glomus intraradices Schenck & Smith and Glomus etunicatum Becker & Gerd. Roots from two similarly non-mycotrophic species, spinach (Chenopodiaceae) and Amaranthus retroflexus L. (Amaranthaceae), had no effect on the germination of spores of G. intraradices. The roots of two out of three mycotrophic species examined were stimulatory to germination of G. intraradices. To test the hypothesis that the inhibition of VAM fungus spore germination by the roots of B. kaber and B. nigra was due to isothiocyanates (mustard oils), lysine, arginine and glutathione were added separately to the nutrient solutions applied to the plants. These compounds were expected to react with isothiocyanates released into the rhizosphere. In one experiment, lysine, arginine and glutathione restored the germination of G. intraradices to control levels for B. kaber, and nearly to the control levels for B. nigra. In a second experiment employing lower concentrations of lysine, arginine and glutathione, germination of spores of G. etunicatum in the presence of B. kaber roots was restored nearly to the levels of controls. In the same experiment, these treatments had no significant effects on spore germination in the presence of B. nigra roots. Lysine and arginine also protected spores of G. etunicatum from in vitro reactions of B. kaber root glucosinolate extract with myrosinase. The involvement of isothiocyanates in the resistance of mustards to VAM fungi is discussed.

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Section: Introductionmentioning

confidence: 99%

Mustards, mustard oils and mycorrhizas

1993

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“…Although a variety of methods are available for the preparation of isothiocyanates (Assony, 1961), the substituted benzyl isothiocyanates required for the above purpose were conveniently prepared by two classical procedures involving the formation of dithiocarbamates, which are treated with mercuric chloride and steam (Kaluza, 1909) or with ethyl chloroformate followed by alkali (McKay, Garmaise, Gaudry, Baker, Paris, Kay, Just & Schwartz, 1959).…”

Section: Methodsmentioning

confidence: 99%

Structure and Antiviral Activity of Substituted Potassium Benzylaminothiomethane‐sulphonates and Allied Compounds*

Rao

Praphulla

et al. 1967

British Journal of Pharmacology and Chemotherapy

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“…(i) N-amyl-isothiocyanide [9] . To a solution of 35% n-amyl amine (contained 15.7 g n-amyl amine and 30 mL water), 7.2 g NaOH and 16 mL water, 13.7 g CS 2 were added in a dropwise manner in order to keep the temperature at 25℃.…”

Section: Synthesis and Characterization Of Aptmentioning

confidence: 99%

Interaction of APT with BSA or HSA

Cui

Luo

et al. 2006

CHINESE SCI BULL

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In this work, N-n-amyl-N'-(sodium paminobenzenesulfonate) thiourea (APT) containing saturated fatty hydrocarbon group was synthesized. Fluorescence quenching methods in combination with UV absorption spectra and molecule modeling method were used to study the interaction between APT and bovine serum albumin (BSA) or human serum albumin (HSA). The binding constants of APT with BSA or HSA were determined at different temperatures under the optimum conditions based on the fluorescence quenching results. The binding characteristics of APT and BSA or HSA were reported and the binding sites were obtained. The binding mode was suggested to be mainly hydrophobic interaction, which was consistent with molecular modeling study.Keywords: N-n-amyl-N'-(sodium p-aminobenzenesulfonate) thiourea (APT), bovine serum albumin (BSA), human serum albumin (HSA), fluorescence spectroscopy, molecular model.

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Bacteriostats. II.¹ The Chemical and Bacteriostatic Properties of Isothiocyanates and their Derivatives

Cited by 57 publications

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Mustards, mustard oils and mycorrhizas

Mustards, mustard oils and mycorrhizas

Structure and Antiviral Activity of Substituted Potassium Benzylaminothiomethane‐sulphonates and Allied Compounds*

Interaction of APT with BSA or HSA

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Bacteriostats. II.1 The Chemical and Bacteriostatic Properties of Isothiocyanates and their Derivatives

Cited by 57 publications

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Mustards, mustard oils and mycorrhizas

Mustards, mustard oils and mycorrhizas

Structure and Antiviral Activity of Substituted Potassium Benzylaminothiomethane‐sulphonates and Allied Compounds*

Interaction of APT with BSA or HSA

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Bacteriostats. II.¹ The Chemical and Bacteriostatic Properties of Isothiocyanates and their Derivatives