Bacteriophages Could Be a Potential Game Changer in the Trajectory of Coronavirus Disease (COVID-19)

Wojewodzic, Marcin W.

doi:10.1089/phage.2020.0014

Cited by 29 publications

(28 citation statements)

References 52 publications

(67 reference statements)

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“…A recent study showed that SARS-CoV-2 behaves like a bacteriophage, meaning a virus that infects bacteria [ 93 ]. Genetic sequencing of microflora from six severely infected COVID-19 patients in the same family showed the presence of significant amounts of Prevotella in the feces [ 94 ].…”

Section: Effectiveness In Promoting Health: Mechanism Of Action Ofmentioning

confidence: 99%

Probiotics: Versatile Bioactive Components in Promoting Human Health

et al. 2020

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The positive impact of probiotic strains on human health has become more evident than ever before. Often delivered through food, dietary products, supplements, and drugs, different legislations for safety and efficacy issues have been prepared. Furthermore, regulatory agencies have addressed various approaches toward these products, whether they authorize claims mentioning a disease’s diagnosis, prevention, or treatment. Due to the diversity of bacteria and yeast strains, strict approaches have been designed to assess for side effects and post-market surveillance. One of the most essential delivery systems of probiotics is within food, due to the great beneficial health effects of this system compared to pharmaceutical products and also due to the increasing importance of food and nutrition. Modern lifestyle or various diseases lead to an imbalance of the intestinal flora. Nonetheless, as the amount of probiotic use needs accurate calculations, different factors should also be taken into consideration. One of the novelties of this review is the presentation of the beneficial effects of the administration of probiotics as a potential adjuvant therapy in COVID-19. Thus, this paper provides an integrative overview of different aspects of probiotics, from human health care applications to safety, quality, and control.

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Section: Effectiveness In Promoting Health: Mechanism Of Action Ofmentioning

confidence: 99%

Probiotics: Versatile Bioactive Components in Promoting Human Health

et al. 2020

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“…Further, excessive use of drugs can severely disrupt the microorganism communities in human bodies, causing massive elimination of beneficial microbes and aggressive selection of drug-resistant species (Croswell et al 2009;Lawley et al 2009;SanMiguel et al 2017). Infections by drug-resistant pathogens lead to higher morbidity and mortality in patients, and impose additional burden and costs on our society (Wojewodzic 2020). In the United States alone, at least 2.8 million people are infected with antibiotic-resistant bacteria each year, and more than 35,000 people eventually die from these infections (CDC 2019).…”

Section: Synthetic Drugs and Microbial Resistancementioning

confidence: 99%

“…Systems biologist Marcin Wojewodzic recently commented that phages could be used to help COVID-19 patients by suppressing bacterial co-infections and producing antibodies (Wojewodzic 2020). Indeed, some phages are known to prey on bacterial pathogens that can cause human respiratory failure.…”

Section: Phages As Predators For Bacterial Pathogensmentioning

confidence: 99%

Smarter cures to combat COVID-19 and future pathogens: a review

Han

Lichtfouse

2021

Environ Chem Lett

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Prevention is better than cure. A milestone of the anthropocene is the emergence of a series of epidemics and pandemics often characterized by the transmission of a pathogen from animals to human in the past two decades. In particular, the coronavirus disease 2019 (COVID-19) has made a profound impact on emergency responding and policy-making in a public health crisis. Classical solutions for controlling the virus, such as travel restrictions, lockdowns, repurposed drugs and vaccines, are socially unpopular and medically limited by the fast mutation and adaptation of the virus. This is exacerbated by microbial resistance to therapeutic drugs and the slowness of vaccine development. In other words, microbial pathogens are somehow 'smarter' and faster than us, thus calling for more intelligent cures to combat future pandemics. Here, we compare therapeutics for COVID-19 such as synthetic drugs, vaccines, antibodies and phages. We present the strength and limitations of antibiotic and antiviral drugs, vaccines, and antibody-based therapeutics. We describe smarter, cheaper and preventive cures such as bacteriophages, food medicine using probiotics and prebiotics, sports, healthy diet, music, yoga, Tai Chi, dance, reading, knitting, cooking and outdoor activities. Some of these preventive cures have been intuitively developed since thousands of years ago, as illustrated by the fascinating similarity of the Chinese characters for 'music' and 'herbal medicine.'

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“…Phage therapy will help control diseases involving antibiotic resistance. This is an insight into use of bacteriophages to control COVID-19 in a post-treatment-control era 44 . Research shows that other microorganisms enhance the activities of T cells by increasing their ability to respond to pathogenic microorganisms 45 .…”

Section: Benefits Of the Microbiotamentioning

confidence: 99%

Microbiota and their Influence in the Human Body

Al-Judaibi¹

2021

J Pure Appl Microbiol

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Scientists have invested considerable resources in the study of the microbiota of the human body. These microorganisms play pivotal roles in immunity and disease. Of which, probiotics are live beneficial microorganisms that keep your intestinal or lung microbiota healthy, and occupy a special role in combating the infections. Thus, it is critical to understand their contributions to these processes. Technology can facilitate advanced studies of the microbiota, including how it develops and its positive and negatives effects on the immune system. This paper investigates how several factors (e.g. birth delivery mode, metabolic activities, types of microorganisms, and immune system interactions) affect the microbiota, particularly in early life. The paper also discusses how gastrointestinal microbes in particular may be associated with certain disease processes, such as those related to schizophrenia, autism, and diabetes. Clinical studies show that certain probiotic strains, like Lactobacillus rhamnosus GG and Bifidobacterium animalis ssp. lactis help to prevent infection of pathogenic organisms (both bacterial and viral). This research may yield crucial contributions to disease prevention and public health. The dysbiosis may result in changes in the acquired immunity later on. The probiotic strains can prevent viral replication during SARS-CoV-2 or COVID-19 infection by reducing proinflammatory cytokines. There has been much interest into the intestinal flora as proposed by the diversity, volume, and proposed role in disease. Future research in the field of microbiome should be done in order to uncover their association to gut virome by noting both their influence on each other and relevant health and disease.

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Bacteriophages Could Be a Potential Game Changer in the Trajectory of Coronavirus Disease (COVID-19)

Cited by 29 publications

References 52 publications

Probiotics: Versatile Bioactive Components in Promoting Human Health

Probiotics: Versatile Bioactive Components in Promoting Human Health

Smarter cures to combat COVID-19 and future pathogens: a review

Microbiota and their Influence in the Human Body

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