Bacteriophages: a Panacea in Neuro-Urology?

Leitner, Lorenz; Kessler, Thomas M.; Klumpp, Jochen

doi:10.1016/j.euf.2019.10.018

Cited by 11 publications

(5 citation statements)

References 13 publications

(17 reference statements)

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“…Renewed interest in the use of bacteriophages, an accepted therapy in several Eastern European countries, could be a promising future treatment option [ 29 , 30 ]. To further reduce antibiotic consumption, the necessity of antibiotic prophylaxis for invasive diagnostics and minimal invasive treatments in presence of ABU should be explored [ 31 ].…”

Section: Discussion and Interpretationmentioning

confidence: 99%

Indwelling catheter vs intermittent catheterization: is there a difference in UTI susceptibility?

et al. 2023

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Background Patients with neurogenic lower urinary tract dysfunction (NLUTD) often rely on some type of catheterization for bladder emptying. Intermittent catheterization (IC) is considered the gold standard and is preferred over continuous catheterization, since it is considered to cause fewer urinary tract infections (UTIs) than indwelling catheterization. The main objective of our study was to describe UTI prevalence (at visit) and incidence (within the last 12 months) and urine culture characteristics between patients using an indwelling catheter versus (vs) those performing IC. Methods In this cross-sectional study, we prospectively evaluated from 02/2020 to 01/2021 patients with NLUTD undergoing urine cultures for prophylactic reasons or due to UTI symptoms. At visit, all patients underwent a standardized interview on current UTI symptoms as well as UTI history and antibiotic consumption within the past year. Patients using an indwelling catheter (n = 206) or IC (n = 299) were included in the analysis. The main outcome was between-group differences regarding UTI characteristics. Results Patients using an indwelling catheter were older (indwelling catheter vs IC: median 66 (Q1-Q3: 55—77) vs 55 (42—67) years of age) and showed a higher Charlson comorbidity index (indwelling catheter vs IC: median 4 (Q1-Q3: 2–6) vs 2 (1–4) (both p < 0·001). A total of 40 patients from both groups were diagnosed with a UTI at visit (indwelling catheters vs IC: 8% (16/206) vs 8% (24/299); p = 0·782), and the number of UTIs within the past 12 months was not significantly different between groups. Overall, Escherichia coli (21%), Enterococcus faecalis (17%), and Klebsiella spp. (12%) were the most frequently detected bacteria. Conclusions In this cohort of patients with NLUTD, we did not find relevant differences in UTI frequency between groups. These results suggest that UTI-related concerns should not be given undue emphasis when counseling patients for catheter-related bladder emptying methods.

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Section: Discussion and Interpretationmentioning

confidence: 99%

Indwelling catheter vs intermittent catheterization: is there a difference in UTI susceptibility?

et al. 2023

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“…Further work is needed regarding the utility and safety of bacteriophages in CAUTI prevention. 109 Given their specificity, and the multiple causative organisms of CAUTI, a bacteriophage cocktail may prove to be a promising approach. This may include a general approach, wherein the cocktail is designed to inhibit the most common causative organisms of CAUTI, or a personalized precision approach wherein the cocktail is designed for a specific patient based on clinical and microbiological history.…”

Section: Bacteriophagesmentioning

confidence: 99%

Catheter-Associated Urinary Tract Infections: Current Challenges and Future Prospects

Werneburg¹

2022

RRU

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Catheter-associated urinary tract infection (CAUTI) is the most common healthcare-associated infection and cause of secondary bloodstream infections. Despite many advances in diagnosis, prevention and treatment, CAUTI remains a severe healthcare burden, and antibiotic resistance rates are alarmingly high. In this review, current CAUTI management paradigms and challenges are discussed, followed by future prospects as they relate to the diagnosis, prevention, and treatment. Clinical and translational evidence will be evaluated, as will key basic science studies that underlie preventive and therapeutic approaches. Novel diagnostic strategies and treatment decision aids under development will decrease the time to diagnosis and improve antibiotic accuracy and stewardship. These include several classes of biomarkers often coupled with artificial intelligence algorithms, cell-free DNA, and others. New preventive strategies including catheter coatings and materials, vaccination, and bacterial interference are being developed and investigated. The antibiotic pipeline remains insufficient, and new strategies for the identification of new classes of antibiotics, and rational design of small molecule inhibitor alternatives, are under development for CAUTI treatment.

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“…Four phage therapy narrative reviews and a systematic review with a small section on UTI management have been published ( Table 1 ), but these are limited in scope with respect to timeframe, language, and/or research subjects. 14–18 Thus, we sought to generate a comprehensive systematic review that includes both a One Health lens and non-English language publications on the role of phages as a suitable alternative or adjuvant therapy for managing UTIs in humans and animals.…”

Section: Introductionmentioning

confidence: 99%

Phage Therapy in the Management of Urinary Tract Infections: A Comprehensive Systematic Review

Al-Anany,

Hooey,

Cook

et al. 2023

PHAGE

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Urinary tract infections (UTIs) are a problem worldwide, affecting almost half a billion people each year. Increasing antibiotic resistance and limited therapeutic options have led to the exploration of alternative therapies for UTIs, including bacteriophage (phage) therapy. This systematic review aims at evaluating the efficacy of phage therapy in treating UTIs. We employed a comprehensive search strategy for any language, any animal, and any publication date. A total of 55 in vivo and clinical studies were included. Of the studies, 22% were published in a non-English language, 32.7% were before the year 1996, and the rest were after 2005. The results of this review suggest that phage therapy for UTIs can be effective; more than 72% of the included articles reported microbiological and clinical improvements. On the other hand, only 5 randomized controlled trials have been completed, and case reports and case series information were frequently incomplete for analysis. Overall, this comprehensive systematic review identifies preliminary evidence supporting the potential of phage therapy as a safe and viable option for the treatment of UTIs.

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Bacteriophages: a Panacea in Neuro-Urology?

Cited by 11 publications

References 13 publications

Indwelling catheter vs intermittent catheterization: is there a difference in UTI susceptibility?

Indwelling catheter vs intermittent catheterization: is there a difference in UTI susceptibility?

Catheter-Associated Urinary Tract Infections: Current Challenges and Future Prospects

Phage Therapy in the Management of Urinary Tract Infections: A Comprehensive Systematic Review

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