Bacteriophage Typing of Methicillin Resistant Staphylococcus aureus and Changing Trend in their Antibiotic Profile

Velayudham, Abarna; Manavalan, Jayavarthinni; Vadivel, Sindhanai; Kaliyamoorthy, Bhaskaran; Kuthalaramalingam, Sethumadhavan

doi:10.21276/aimdr.2017.3.1.mb1

Cited by 1 publication

(1 citation statement)

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“…However, a study has demonstrated that phage typing can be helpful in the epidemiological surveillance and outbreak investigation of MDR Salmonella Typhimurium [89]. In addition to S. Typhimurium, a set of 23 phages was also used in the phage typing of MRSA for epidemiological monitoring, with a majority of the MRSA strains (84%) proving to be typable [90]. Furthermore, phage typing in conjunction with antibiotic susceptibility testing has also been shown to facilitate in the identifying of different strains of MDR K. pneumoniae that co-occur at an infection site [91].…”

Section: Clinical Mdr Bacterial Treatmentmentioning

confidence: 99%

Bacteriophages and Their Host Range in Multidrug-Resistant Bacterial Disease Treatment

Chung,

Liau,

Tang

2023

Pharmaceuticals

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The rapid emergence of multidrug-resistant (MDR) bacteria in recent times has prompted the search for new and more potent antibiotics. Bacteriophages (commonly known as phages) are viruses that target and infect their bacterial hosts. As such, they are also a potential alternative to antibiotics. These phages can be broadly categorized into monovalent (with a narrow host range spectrum and specific to a single bacterial genus) and polyvalent (with a broad host range and specific to more than two genera). However, there is still much ambiguity in the use of these terms, with researchers often describing their phages differently. There is considerable research on the use of both narrow- and broad-host range phages in the treatment of infections and diseases caused by MDR bacteria, including tuberculosis, cystic fibrosis, and carbapenem-resistant Enterobacterales (CRE) infectious diseases. From this, it is clear that the host range of these phages plays a vital role in determining the effectiveness of any phage therapy, and this factor is usually analyzed based on the advantages and limitations of different host ranges. There have also been efforts to expand phage host ranges via phage cocktail development, phage engineering and combination therapies, in line with current technological advancements. This literature review aims to provide a more in-depth understanding of the role of phage host ranges in the effectiveness of treating MDR-bacterial diseases, by exploring the following: phage biology, the importance of phages in MDR bacteria diseases treatment, the importance of phage host range and its advantages and limitations, current findings and recent developments, and finally, possible future directions for wide host range phages.

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Section: Clinical Mdr Bacterial Treatmentmentioning

confidence: 99%