“…Additionally, the mode of binding and organisation of chlorpromazine, an antipsychotic amphipathic medication, complexed with PRD1 A (an icosahedral membrane-containing and double-stranded DNA phage) capsid protein P3 (43 kDa), in trimeric units, was reported by Duyvesteyn et al 79 The results showed that although the PRD1 membrane enabled the ejection of phage DNA without biochemical or genetic modifications, the injection of the drug was achieved following specific mixing procedures with PRDI, with subsequent cryo-electron microscopy, crystallography, and molecular and biochemical dynamic techniques showing the accumulation of the drug at particular locations in the PRD1 capsid while maintaining the stability of the virions. The accumulation was attributed to the formation of micelles, polar N , N -dimethyl propylamine moieties associated with the negatively charged residues at the capsid protein P3 jellyrolls, and the formation of turreted morphology led to the packed and specific hexagonal lattice formation.…”