Bacteriophage‐based cocktail modulates selected immunological parameters and post‐challenge survival of rainbow trout (<i>Oncorhynchus mykiss</i>)

Schulz, P.; Pajdak‐Czaus, Joanna; Robak, S.; Dastych, Jarosław; Siwicki, Andrzej K.

doi:10.1111/jfd.13026

Cited by 18 publications

(21 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The same group studied also the effect of BAFADOR ® on the rainbow trout's immune system when a mixed infection of Aeromonas and Pseudomonas was induced. As in the previous case, an immunomodulating effect was achieved and higher survival rates in the treated groups were observed [68].…”

Section: Immune Response and Clearance From The Bodysupporting

confidence: 76%

“…It is also worth to mention that no adverse side effects have been observed so far when the phage therapy was applied in aquaculture because lower vertebrates are reported to be resistant to endotoxic shock. Therefore, LPS is rather considered here as an immunostimulant, inducing an immune system to react [36,68].…”

Section: Immune Response and Clearance From The Bodymentioning

confidence: 99%

“…Immersion is a good way for the application of bacteriophages as protective agents against bacterial diseases. However, when the disease is external or when phages cross some natural barriers and arrive at the internal site of the infection, immersion can be applied also as a treatment [68]. Khairnar described the successful usage of phages against antibiotic-resistant strains of Pseudomonas aeruginosa by direct application to the infected skin lesion of catfish with a cotton swab [83].…”

Section: Formulation and Administration Of Phage Preparationsmentioning

confidence: 99%

See 2 more Smart Citations

Growing Trend of Fighting Infections in Aquaculture Environment—Opportunities and Challenges of Phage Therapy

Kowalska¹,

Kazimierczak²,

Sowińska³

et al. 2020

Antibiotics

Self Cite

View full text Add to dashboard Cite

Phage therapy, a promising alternative to antimicrobial treatment of bacterial diseases, is getting more and more popular, especially due to the rising awareness of antibiotic resistance and restrictions in antibiotics’ use. During recent years, we observed a growing trend of bacteriophages’ application in aquaculture, which in each year reports high losses due to bacterial diseases. This review provides an update of the status of bacteriophage therapy for the treatment and prevention of infections in the aquatic environment. As it is still mostly in the scientific stage, there are a few constraints that may prevent effective therapy. Therefore, specific characteristics of bacteriophages, that can act in favor or against their successful use in treatment, were described. We underlined aspects that need to be considered: specificity of phages, bacterial resistance, safety, immune response of the host organism, formulation, administration and stability of phage preparations as well as bacteriophages’ influence on the environment. The biggest challenge to overcome is finding the right balance between the desired and problematic characteristics of bacteriophages. Finally, regulatory approval challenges may be encountered by bacteriophage manufacturers. Even though there are still some technical constraints connected with the global use of bacteriophage therapy, it was concluded that it can be successfully applied in aquaculture.

show abstract

Section: Immune Response and Clearance From The Bodysupporting

confidence: 76%

Section: Immune Response and Clearance From The Bodymentioning

confidence: 99%

Section: Formulation and Administration Of Phage Preparationsmentioning

confidence: 99%

See 1 more Smart Citation

Growing Trend of Fighting Infections in Aquaculture Environment—Opportunities and Challenges of Phage Therapy

Kowalska¹,

Kazimierczak²,

Sowińska³

et al. 2020

Antibiotics

Self Cite

View full text Add to dashboard Cite

show abstract

“…Therefore, we must empirically verify this critical parameter. Very recently, a phage cocktail containing seven bacteriophages (three against A. hydrophila and four against P. fluorescens ) has been tested in the European eel ( Anguilla anguilla ) and rainbow trout ( Oncorhynchus mykiss ), reducing the mortality of fish challenged with strains of these two species of bacteria [ 56 , 197 ]. Cocktails have also been used successfully in laboratory tests or small field trials in food protection or veterinary and human medicine [ 198 , 199 , 200 , 201 ].…”

Section: Potential Of Phage Therapy In Aquaculture Settingsmentioning

confidence: 99%

Phage Therapy as a Focused Management Strategy in Aquaculture

Ramos-Vivas

Superio

Galindo-Villegas

et al. 2021

IJMS

View full text Add to dashboard Cite

Therapeutic bacteriophages, commonly called as phages, are a promising potential alternative to antibiotics in the management of bacterial infections of a wide range of organisms including cultured fish. Their natural immunogenicity often induces the modulation of a variated collection of immune responses within several types of immunocytes while promoting specific mechanisms of bacterial clearance. However, to achieve standardized treatments at the practical level and avoid possible side effects in cultivated fish, several improvements in the understanding of their biology and the associated genomes are required. Interestingly, a particular feature with therapeutic potential among all phages is the production of lytic enzymes. The use of such enzymes against human and livestock pathogens has already provided in vitro and in vivo promissory results. So far, the best-understood phages utilized to fight against either Gram-negative or Gram-positive bacterial species in fish culture are mainly restricted to the Myoviridae and Podoviridae, and the Siphoviridae, respectively. However, the current functional use of phages against bacterial pathogens of cultured fish is still in its infancy. Based on the available data, in this review, we summarize the current knowledge about phage, identify gaps, and provide insights into the possible bacterial control strategies they might represent for managing aquaculture-related bacterial diseases.

show abstract

“…Reports on phage immunomodulatory activity in rainbow trout subjected to phage treatment also came from Schulz et al [106]. The authors used a commercially available phage cocktail called BAFADOR, intended for use in aquaculture niches.…”

Section: Fish Immunitymentioning

confidence: 99%

Phages as a Cohesive Prophylactic and Therapeutic Approach in Aquaculture Systems

2020

View full text Add to dashboard Cite

Facing antibiotic resistance has provoked a continuously growing focus on phage therapy. Although the greatest emphasis has always been placed on phage treatment in humans, behind phage application lies a complex approach that can be usefully adopted by the food industry, from hatcheries and croplands to ready-to-eat products. Such diverse businesses require an efficient method for combating highly pathogenic bacteria since antibiotic resistance concerns every aspect of human life. Despite the vast abundance of phages on Earth, the aquatic environment has been considered their most natural habitat. Water favors multidirectional Brownian motion and increases the possibility of contact between phage particles and their bacterial hosts. As the global production of aquatic organisms has rapidly grown over the past decades, phage treatment of bacterial infections seems to be an obvious and promising solution in this market sector. Pathogenic bacteria, such as Aeromonas and Vibrio, have already proved to be responsible for mass mortalities in aquatic systems, resulting in economic losses. The main objective of this work is to summarize, from a scientific and industry perspective, the recent data regarding phage application in the form of targeted probiotics and therapeutic agents in aquaculture niches.

show abstract

Bacteriophage‐based cocktail modulates selected immunological parameters and post‐challenge survival of rainbow trout (Oncorhynchus mykiss)

Cited by 18 publications

References 35 publications

Growing Trend of Fighting Infections in Aquaculture Environment—Opportunities and Challenges of Phage Therapy

Growing Trend of Fighting Infections in Aquaculture Environment—Opportunities and Challenges of Phage Therapy

Phage Therapy as a Focused Management Strategy in Aquaculture

Phages as a Cohesive Prophylactic and Therapeutic Approach in Aquaculture Systems

Contact Info

Product

Resources

About