Bacteriology of urinary tract infection among patients with acquired immunodeficiency syndrome in Jos, Nigeria

Jombo, Gta; Egah, DZ; Ayeni, J A

doi:10.4314/njm.v14i4.37202

Cited by 5 publications

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“…Escherichia coli was the most predominant pathogen with a prevalence of 38.5%. This is in line with similar reports from previous studies [1,12,[18][19][20].…”

Section: Discussionsupporting

confidence: 94%

“…The study revealed 5.8% prevalence of uropathogens in tandem with results of similar study obtained elsewhere [2,[12][13]. There have been several studies on this subject and it is expected that the stakeholders involved in management of HIV positive individuals have utilized the result emanating from previous study, hence the low prevalence observed in this study.…”

Section: Discussionsupporting

confidence: 85%

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Prevalence of Urinary Tract Infection in HIV Patients on Antiretroviral Drugs in Jos Metropolis, Nigeria

Sheyin¹

2018

WJPH

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Prevalence of UTI in HIV patients is well documented in several studies across the world, but there is paucity of data as regards UTI in HIV patients in Jos metropolis, Nigeria. The study was designed to determine the prevalence of urinary tract infection in HIV positive patients in Jos metropolis and their antibiotic susceptibility pattern. Two hundred and twentyfive mid-stream urine samples were obtained from HIV patients. Samples were cultured on cysteine lactose electrolyte deficient (CLED) agar and blood agar. Gram staining and biochemical tests were carried out to identify the bacteria isolates. Sensitivity testing was performed on isolates using disc diffusion method. Of the 225 HIV patients tested, 13(5.8%) were positive for UTI of which males had 5(4.8%) while the females had 8(6.6%). The study showed the presence of UTI in all age groups with the exception of age group ≥46yrs. The low prevalence of urinary tract infection recorded in the present study is an indication of the efficacy of prophylaxis administered to HIV patients to prevent opportunistic infection.

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“…Escherichia coli was the most predominant pathogen with a prevalence of 38.5%. This is in line with similar reports from previous studies [1,12,[18][19][20].…”

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 85%

Prevalence of Urinary Tract Infection in HIV Patients on Antiretroviral Drugs in Jos Metropolis, Nigeria

Sheyin¹

2018

WJPH

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“…This demonstrates that women seek medical care and visit hospitals more frequently than men. The results of this investigation are consistent with a study by Jumbo et al (2006), which found that hospital attendance was more common among women than men. The specimen distribution for urine showed the highest number of specimens collected, with a higher proportion of female specimens.…”

Section: Discussionsupporting

confidence: 92%

Class 1 Integron (Inti1) Gene In Gram Negative Multi-Drug Resistant Bacteria Isolated From Clinical Samples In Bayelsa State, Nigeria

Tolulope,

Ewaoche,

Nnenna

2024

RAS Medical Science

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Background and Objective: Integrons are common features of bacterial genomes that allow efficient capture and expression of new genes which are embedded in gene cassettes. Class 1 integron are mostly identified among clinical Gram-negative bacteria as the major factor responsible for drug resistance. This study was aimed at detecting the presence of the integron-integrase 1 gene (inti1) in Gram negative bacteria. Materials and Methods: The isolates were determined using Standard Bacteriological methods. Antibiotic susceptibility testing was carried out using Modified Kirby Bauer disc-diffusion method and the genomic DNA was extracted by boiling method. The presence of Inti1 gene was determined using Polymerase Chain Reaction. Results: A total of 121 clinical samples were collected, of which 99 (81.8%) were urine samples, 5 (4.13%) were Endocervical swabs, 4 (3.31%) were sputum samples, 4 (3.31%) were High vaginal swabs, 6 (4.95%) were wound samples and 3 (2.48%) were ear swabs, 45 (37.2%) samples were collected from males and 76 (62.8%) were collected from females. The findings showed that out of 121 samples analysed, a total of 95 isolates were obtained from the samples with E.coli having a high prevalence of 32 (33.7%), followed by Klebsiella oxytoca 30 (31.6%), Klebsiella pneumonia 21 (22.1%), Pseudomonas aeruginosa 6 (6.31%), Enterobacter aerogenes 3 (3.2%) and Citrobacter fruendii 3 (3.2%). Antibiotics susceptibility pattern showed the resistance percentage of each of the antibiotics used; Gentamicin (50.5%) Pefloxacine (68.4), Narivid (67.4%), Streptomycin (81.1%), Septrin (66.3%) Chloramphenicol (70.5%), Spectinomycin (53.7%), Ciprofloxacin (56.8%), Amoxacillin (53.7%) and Augmentin (88.4%). Out of the 30 isolates selected for molecular analysis, the Inti 1 gene was detected in 26 isolates. Conclusion: This study showed that there is high prevalence of class 1 integron in multi-drug resistant Gram-negative bacteria. To prevent the development of multi-drug resistance bacteria, the indiscriminate use of antibiotics should be avoided.

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“…The sample size was determined using the single proportion method and prevalence of 12.3% as reported by Jombo et al, (2006a…”

Section: Determination Of Sample Sizementioning

confidence: 99%

Prevalence Of Extended Spectrum Beta-Lactamases (ESBLs)-Producing Escherichia Coli Isolated From UTI Patients Attending some Selected Hospitals In Minna, Nigeria

Iseghohi¹,

Igwe²,

Galadima³

et al. 2021

Nig. J. Biotechnol

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Globally, urinary tract infections are one of the most common infections in need of urgent clinical attention. The prevalence of extended spectrum beta-lactamases (ESBL)- producing Escherichia coli isolated from urine samples of some UTI patients and s of apparently healthy individuals in Minna, Nigeria, is investigated. Standard microbiological techniques were used to conduct this study. A total of 170 catch midstream urine samples submitted to the Medical Microbiology Laboratories of 4 different hospitals (and samples from healthy individuals) were randomly collected for 5 months and examined for microbial growths. Female patients (65.9%) submitted more urine samples for UTI test than their male counterpart (34.1%). The age ranges of 21 -30 (26.5%) and 31 - 40 (25.3%) had the highest percentages of infection rate while those within the ages 1- 10 (3.5%) and ≥ 71 (2.3%) were the least infected. This study observed a prevalence of 23.5% of E. coli in Minna metropolis and a significant number (30%) of healthy individuals (HI) was observed to harbor the E. coli in their urine. The isolates were highly susceptible to Gentamicin (65%), Ofloxacin (65%), Tetracycline (62.5%), Cotrimoxazole (62.5%), and Streptomycin (57.5%). Mildly susceptible to Pefloxacin (37.5%), Chloramphenicol (37.5%), and Ciprofloxacin (35%). There were significant resistance to most of the beta-lactames tested [Cefuroxime (80%), Amoxicillin (42.5%), Augmentin (40), Cefotaxime (20%) and Ceftaxidime (7.5%)]. Two of the isolates were resistant to all the 13 antibiotics tested; 70% (28) of the isolates had multiple antibiotics resistance index (MARI) ≥0.3. Multidrug resistance was expressed in 37.5% of the isolates tested. The study showed a vast resistant pool in the environment. Only 25% of the E. coli isolated from the urine samples produced beta-lactamases phenotypically, most of which expressed resistance to more than 5 of the antibiotics tested and had MARI of ≥ 0.5. Further evaluation showed that 25% (10/40) of the E. coli isolated from the UTI patients in Minna, Nigeria, were ESBL- producers and could harbor one or two of the genes. TEM gene was expressed in 70% (7) of the isolates that produced ESBL phenotypically, 60% 6) harbored CTXM gene, 20% (2) had the OXA gene while none of the bacteria harbored the SHV gene. The study established a 5.9% ESBL prevalence among the E. coli isolated from UTI in the environment studied. This study established that E. coli is one of the prevalent bacteri urea majorly isolated from UTI patients in Minna. The prevalent E. coli are multidrug resistant and could harbor more than one ESBL gene . keywords: Escherichia coli, Minna, UTI, ESBL, Multidrug resistance

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Bacteriology of urinary tract infection among patients with acquired immunodeficiency syndrome in Jos, Nigeria

Cited by 5 publications

References 0 publications

Prevalence of Urinary Tract Infection in HIV Patients on Antiretroviral Drugs in Jos Metropolis, Nigeria

Prevalence of Urinary Tract Infection in HIV Patients on Antiretroviral Drugs in Jos Metropolis, Nigeria

Class 1 Integron (Inti1) Gene In Gram Negative Multi-Drug Resistant Bacteria Isolated From Clinical Samples In Bayelsa State, Nigeria

Prevalence Of Extended Spectrum Beta-Lactamases (ESBLs)-Producing Escherichia Coli Isolated From UTI Patients Attending some Selected Hospitals In Minna, Nigeria

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