Bacteriology of the Human Liver

Sborov, Victor M.; Morse, Warren C.; Giges, Burton; Jahnke, Edward J.

doi:10.1172/jci102692

Cited by 29 publications

(3 citation statements)

References 19 publications

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“…Two observations of interest are the following: 1) Fifteen liver biopsies from humans taken during operation were sterile for aerobes and anaerobes, thus confirming the findings of Romieu and Brunschwig( 13) and S b r o v et al ( 14): 2 ) The organs of 10 nearly mature d'og embryos from 2 mother dogs, which showed the usual contamination, were sterile.…”

Section: H M I O Nsupporting

confidence: 77%

Bacteriology of the Healthy Experimental Animal

Schweinburg

Sylvester

1953

Experimental Biology and Medicine

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Section: H M I O Nsupporting

confidence: 77%

Bacteriology of the Healthy Experimental Animal

Schweinburg

Sylvester

1953

Experimental Biology and Medicine

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“…In such instances, in our laboratory and elsewhere, non¬ specific septicemia has been found within 12 hours of such irradiation and irregularly thereafter during the next 7 to 10 days. 4. Septicemia may be associated irregularly with cases of cirrhosis of the liver.…”

Section: Discussionmentioning

confidence: 99%

A Bacteriologic Study of Portal-Vein Blood in Man

Schatten¹

1955

Arch Surg

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“…Auch beim Menschen finden sich wie im vorliegenden Tiermodell vereinzelt Darmbakterien in Pfortader und Leber, ohne dab die Darmwand entzfindlich ver/indert ist [20,21]. Diese Bakterien werden offenbar unter normalen Umst/inden vonder Leber entweder fiber die Gallenblase wieder in den Darm ausgeschieden oder durch das reticuloendotheliale System phagocytiert.…”

Section: Diskussionunclassified

Experimentelle Gallensteinbildung. �tiologische Bedeutung von?-Glucuronidase-bildenden Bakterien und Gallenwegsobstruktionen

Hancke¹,

Marklein²

1983

Langenbecks Arch Chiv

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Bile pigment gallstones were produced in six of six mongrel dogs by narrowing the cystic duct with ligature after a postoperative interval of seven days. beta-Glucuronidase producing group G Streptococcus and Staphylococcus aureus were found in the bile, the gallbladder wall, and the liver. In another trial similar gallstones were produced in four of eight dogs after mere injection of beta-glucuronidase producing Escherichia coli into the spleen resp. in six of eight dogs after injection of E. coli into the colon without ligature of the cystic duct. In an additional series gallstones were produced in six dogs after injection of beta-glucuronidase producing E. coli into the colon plus ligature of the cystic duct. The injected strain of E. coli was found in the bile, the gallbladder wall, the liver, and even within the produced gallstones. In a control group in none of six dogs gallstones were present. beta-Glucuronidase producing group G Streptococcus was found in the gallbladder of one dog, Pseudomonas aeruginosa was found in the gallbladder of another dog and Staphylococcus aureus in the liver and gallbladder wall of a third dog. We conclude from our experiments that merely bacterial infection of the biliary tract can lead to gallstone formation. The bacterial colonization of the liver and the biliary tract is promoted by biliary tract obstruction. beta-Glucuronidase producing bacteria increase the amount of beta-glucuronidase in the bile thus leading to calcium bilirubinate precipitation and gallstone formation by deconjugation of bilirubindiglucuronide.

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Bacteriology of the Human Liver

Cited by 29 publications

References 19 publications

Bacteriology of the Healthy Experimental Animal

Bacteriology of the Healthy Experimental Animal

A Bacteriologic Study of Portal-Vein Blood in Man

Experimentelle Gallensteinbildung. �tiologische Bedeutung von?-Glucuronidase-bildenden Bakterien und Gallenwegsobstruktionen

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