Bacteriology of recurrent exacerbation of postoperative course in chronic rhinosinusitis in relation to asthma

Ikeda, Katsuhisa; Yokoi, Hidenori; Kusunoki, Takeshi; Saitoh, Tatsuya; Yao, Toru; Kase, Kaori; Minekawa, Akira; Inoshita, Ayako; Kawano, Kenji

doi:10.1016/j.anl.2010.10.009

Cited by 16 publications

(21 citation statements)

References 20 publications

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“…Eosinophil peroxidase catalyzes the oxidation of halides by H 2 O 2 to form hypohalous acids. Hypohalous acid production is important in the host defense against infectious agents, which is one the exacerbating factors of eosinophilic CRS with nasal polyps [20]. However, during this reaction, the hydroxyl radical, which is a powerful and indiscriminate oxidant, is also produced.…”

Section: Discussionmentioning

confidence: 99%

Reduction in Superoxide Dismutase Expression in the Epithelial Mucosa of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps

Ono

Kusunoki²,

Miwa³

et al. 2013

Int Arch Allergy Immunol

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Background: Eosinophils generate large amounts of oxidant species. The eosinophil-dominant type of chronic rhinosinusitis (CRS) with nasal polyps is related to more extensive disease and a decreased likelihood of surgical success. Superoxide dismutase (SOD) is the first-line and only antioxidant enzyme that converts superoxide to hydrogen peroxide. Methods: The patients with CRS with nasal polyps were divided into eosinophilic and noneosinophilic groups. The expression of three isoforms of SOD, intracellular copper-zinc SOD (CuZnSOD), mitochondrial manganese SOD (MnSOD) and extracellular SOD (ECSOD), were examined by enzyme activity assay, immunohistochemistry and quantitative real-time RT-PCR sampled by laser capture microdissection. Results: SOD activity in the eosinophilic and noneosinophilic groups was significantly reduced compared to that of the control groups. Immunostaining of both CuZnSOD and MnSOD in the eosinophilic group was significantly decreased compared with that in the noneosinophilic and control groups. CuZnSOD mRNA of the eosinophilic group was significantly decreased compared with that of the control group, whereas MnSOD mRNA in the eosinophilic group was significantly decreased compared with that in the noneosinophilic and control groups. Neither immunoreactivity nor mRNA of ECSOD was different among the three groups. The degree of epithelial damage and disease severity were inversely correlated with CuZnSOD and MnSOD immunoreactivity. Conclusions: The reduction in SOD activity and the downregulation of the SOD message are suggested to be related to eosinophil recruitment and epithelial damage of CRS with nasal polyps.

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Section: Discussionmentioning

confidence: 99%

Reduction in Superoxide Dismutase Expression in the Epithelial Mucosa of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps

Ono

Kusunoki²,

Miwa³

et al. 2013

Int Arch Allergy Immunol

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show abstract

“…These acute exacerbations did not present with purulent drainage, and may represent a separate subset of acute exacerbations. 1119 Ikeda et al 1120 evaluated 42 subjects with AECRS and asthma post-ESS and found that 38% of these patients developed a decline in peak expiratory flow. In summary, there exists a paucity of data on the diagnostic criteria of AECRS.…”

Section: Ixc Aecrs: Diagnosismentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

554

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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“…Depending on individual characteristics, onset, duration, and season, the sudden onset or worsening of NSS could be an indication for allergic rhinitis (AR), acute rhinosinusitis (ARS), an acute exacerbation of chronic rhinosinusitis (AECRS), or other related diagnoses. Published studies of exacerbation among CRS patients have primarily focused on bacteriology, immunology, and medical treatments, as opposed to population‐based occurrence, severity, risk factors, and natural history. The International Consensus Statement on Allergy and Rhinology (ICAR), therefore, has declared a need for prevalence estimates of AECRS and more prospective studies, especially those which compare several definitions of AECRS …”

Section: Introductionmentioning

confidence: 99%

Prevalence, severity, and risk factors for acute exacerbations of nasal and sinus symptoms by chronic rhinosinusitis status

Kuiper

Hirsch

Bandeen‐Roche

et al. 2018

Allergy

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Bacteriology of recurrent exacerbation of postoperative course in chronic rhinosinusitis in relation to asthma

Cited by 16 publications

References 20 publications

Reduction in Superoxide Dismutase Expression in the Epithelial Mucosa of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps

Reduction in Superoxide Dismutase Expression in the Epithelial Mucosa of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Prevalence, severity, and risk factors for acute exacerbations of nasal and sinus symptoms by chronic rhinosinusitis status

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