Bacteriology of Normal and Diseased Gallbladders

Andrews, Edmund; Henry, L

doi:10.1001/archinte.1935.00170040105007

Cited by 62 publications

(12 citation statements)

References 14 publications

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“…Cefoperazone, which was effective in vitro against P. aeruginosa isolated in this study, sterilized the bile of two patients harboring this agent. As reported previously, P. aeruginosa was observed exclusively in patients with cancer (1,5,10,36). Anaerobes were recovered from six patients.…”

Section: Discussionsupporting

confidence: 75%

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Cefoperazone compared with ampicillin plus tobramycin for severe biliary tract infections

Bergeron

Mendelson

Harding

et al. 1988

Antimicrob Agents Chemother

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In a prospective, randomized, multicenter study, the efficacy and safety of cefoperazone and the combination ampicillin-tobramycin as initial therapy for patients with severe acute biliary tract infections were compared. Of 77 patients initially entered in the study, definite severe biliary tract infection was confirmed in 67. Sixty-four patients completed treatment. At the end of treatment, 35 of 36 (97%) patients given cefoperazone and 23 of 28 (82%) given ampicillin-tobramycin were cured of their infection (P = 0.07). Pathogens were recovered from the bile in 32 patients; microbiological cures were observed in 18 of 19 (94%) patients receiving cefoperazone and 8 of 13 (62%) receiving ampicillin-tobramycin (P = 0.03). Thirteen patients had septicemia. None (0%) of the eight septicemic patients from the cefoperazone group, but two of five (40%) from the ampicillin-tobramycin group, were clinical failures. Of the isolated pathogens, 51% were resistant to ampicillin, while the resistance rate was 4% for tobramycin and 1% for cefoperazone (P < 0.001). Biliary concentrations of cefoperazone were maintained at high levels-236 ± 87

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Section: Discussionsupporting

confidence: 75%

“…In fact, unless cholecystitis occurs in an older patient or is associated with cystic or common bile duct obstruction (1,10,36), the incidence of active infection is less than 50% (11,32).…”

Section: Discussionmentioning

confidence: 99%

Cefoperazone compared with ampicillin plus tobramycin for severe biliary tract infections

Bergeron

Mendelson

Harding

et al. 1988

Antimicrob Agents Chemother

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“…The importance of risk factors for predicting infec tions in patients undergoing biliary tract surgery has been emphasized by many authors [13][14][15], More re cently [8], such risk factors have been more accurately defined. There is now general agreement [7,11,16] that age > 60 years, obstructive jaundice, a history of cholan gitis, previous biliary surgery, CBD stones and emer gency operations are well established risk factors for pre dicting the presence of bacteria in bile.…”

Section: Discussionmentioning

confidence: 99%

Length of Clinical History as a Risk Factor for Infection following Surgery for Gallstone Disease

et al. 1988

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The role of risk factors for predicting infection in surgery for gallstone disease has been evaluated in 96 patients. Conventionally recognized risk factors were present in 43 patients, whereas 53 patients had none. Four patients had polymicrobial bacterial growth in bile and all of them had a clinical history longer than 3 years. There was no statistical difference in postoperative infection rates between the groups (37 and 30%, respectively). In the low-risk group, however, the patients with a clinical history of over 3 years had a postoperative infection rate significantly higher (p = 0.0001 Fisher’s exact test).

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“…In a number of studies, microorganisms were more frequently isolated from gallblad der wall than from gallbladder bile (1)(2)(3)(4)(5)(6)(7). The discrepancy between the two sites of collec tion were frequently due to the additional isolation of staphylococci and aerobic and anaerobic diphtheroid rods from the wall specimen.…”

Section: Gallbladder Culture Sampling Techniquementioning

confidence: 99%

Microflora of the Biliary Tree and Liver – Clinical Correlates

Claesson¹

1986

Dig Dis

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Bacteriology of Normal and Diseased Gallbladders

Cited by 62 publications

References 14 publications

Cefoperazone compared with ampicillin plus tobramycin for severe biliary tract infections

Cefoperazone compared with ampicillin plus tobramycin for severe biliary tract infections

Length of Clinical History as a Risk Factor for Infection following Surgery for Gallstone Disease

Microflora of the Biliary Tree and Liver – Clinical Correlates

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