Bacteriology of Hidradenitis Suppurativa

Oprica, Cristina; Nord, Carl Erik

doi:10.1007/978-3-540-33101-8_11

Cited by 11 publications

(15 citation statements)

References 43 publications

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“…The latter, notably, is, in combination with rifampicin, one of the most widely recommended first-line therapies for HS. Tetracycline is described as an alternative antibiotic agent in HS therapy [26]. However, our data showed a resistance rate of almost 33%.…”

Section: Discussioncontrasting

confidence: 51%

See 1 more Smart Citation

Microbial Profile and Antimicrobial Susceptibility of Bacteria Found in Inflammatory Hidradenitis Suppurativa Lesions

Hessam¹,

Sand²,

Georgas

et al. 2016

Skin Pharmacol Physiol

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Background: The role of bacterial colonization in hidradenitis suppurativa (HS) lesions is poorly understood. To date, data on the related microbial profile and especially on bacterial resistance rates are scarce. Methods: The results of bacterial cultures and susceptibility patterns of the isolated microorganisms obtained from deep portions of HS lesions from patients who underwent surgery at our HS Centre between 2010 and 2015 were retrospectively evaluated. Results: Analyses of 113 bacterial samples from 113 HS patients revealed bacterial growth in 95 samples (84.1%). Polymicrobial growth was found in 51 samples (45.1%). Coagulase-negative staphylococci and Staphylococcus aureus were the most commonly isolated bacteria, followed by Proteus mirabilis and Escherichia coli. Data on susceptibility testing were available for 68 samples, which yielded 129 isolates. The isolated strains were primarily resistant to penicillin G, followed by erythromycin, clindamycin and ampicillin. The highest effectiveness against isolates was observed for fosfomycin, imipenem, fluoroquinolones (moxifloxacin, ciprofloxacin, levofloxacin), and cotrimoxazole. Conclusions: Our findings on bacterial species and their topographical distribution revealed that the microbial flora in HS lesions reflects commensal flora of the skin. Due to the susceptibility rate and immunomodulatory and anti-inflammatory properties, cotrimoxazole may represent an alternative antibiotic agent and should be considered for therapy in HS patients.

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Section: Discussioncontrasting

confidence: 51%

“…In addition to the reduction of bacterial growth, some antibiotic agents (e.g. tetracycline, clindamycin, and minocycline) also have immunomodulatory and anti-inflammatory properties [26,27,28]. …”

Section: Discussionmentioning

confidence: 99%

Microbial Profile and Antimicrobial Susceptibility of Bacteria Found in Inflammatory Hidradenitis Suppurativa Lesions

Hessam¹,

Sand²,

Georgas

et al. 2016

Skin Pharmacol Physiol

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show abstract

“…Although numerous bacteria are found in association with hidradenitis suppurativa (Oprica & Nord 2006) they are not considered to be causative. Streptococcus milleri is frequently found in the lesions and there is some response to antibiotic agents.…”

Section: Hidradenitis Suppurativamentioning

confidence: 99%

Non‐Infective Cutaneous Conditions of the Vulva

Neill

Lewis

2009

Ridley's the Vulva

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“…21,26,27 These findings are supported by the observation that during the proinflammatory phase of HS, neutrophilic infiltration is accompanied by the release of TNF-alfa, which may mediate HS-associated keratinocyte proliferation. 9,16,26,[28][29][30] Observational data, case reports, and limited nonrandomized studies in the literature highlight the potential clinical use of IFX in patients with moderate to severe HS and underscore the need for a controlled, randomized prospective clinical trial. 26,28,[31][32][33][34][35] We report here the results of a single-center, prospective, randomized double-blind, placebo-controlled, open-label crossover trial to examine the efficacy and safety of IFX and placebo on patients with moderate to severe HS.…”

mentioning

confidence: 94%

“…7 In moderate to severe cases, further tissue destruction leads to draining pustules, subcutaneous sinus tracts, and extensive fibrous scars. [8][9][10] HS predominately occurs in skin folds bearing terminal hairs and apocrine glands, typically affecting the axillae, genitofemoral region of female patients, and anogenital region of male patients. 1,8 The lesions are invariably painful, unsightly, odorous, and can have a devastating effect on the patient's quality of life both as a physical ailment and social concern.…”

mentioning

confidence: 99%