Bacteriological study of Amniotic fluid During labor

Four pregnant Macaca nemestrina dams at 140-145 days of gestation received an intraamniotic inoculation of group B streptococci (GBS). All four premature infants were born by cesarean delivery, were bacteremic at birth, and showed symptoms of GBS sepsis similar to infected human infants with early-onset disease. Three infants did not receive antibiotics and died of GBS sepsis by 10 h of age despite mechanical ventilation and fluids for blood pressure support. Penicillin treatment of the fourth infant prolonged survival and decreased the requirement for supportive therapy. Quantitative cultures and histopathology were done on all four infants. Transmission electron microscopy of lung tissue demonstrated GBS within membrane-bound vacuoles of type I and II alveolar epithelium and interstitial fibroblasts. This model should be useful for studying the early steps in the pathogenesis of early-onset GBS infections. GBS may enter alveolar epithelial cells to transit this barrier and ultimately disseminate via the blood-stream.

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Amnionitis caused by Propionibacterium acnes

Reed

Feldman

Cochrane

1988

BJOG

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Case reportA 34-year-old Ghanaian bank clerk was admitted to hospital as an 'in-utero' transfer. The duration of the pregnancy was assessed at 25 weeks. She had a history of dark red vaginal bleeding associated with regular uterine contractions for the previous 6 h.This was her fourth pregnancy: the first, in 1976, resulted in delivery by emergency caesarean section at 38 weeks gestation for fetal distress; the second, in 1979, ended in a normal delivery at 40 weeks gestation; the third, in 1983, was terminated after 8 weeks. The present pregnancy had been complicated by hyperemesis during the first trimester. At 20 weeks gestation, fetoscopy was performed to obtain cord blood for electrophoresis, since both parents had sickle cell trait; the fetal blood was normal. Ultrasound scan at 17 weeks confirmed the dates. After an episode of vaginal bleeding at 22 weeks gestation, another scan showed a lowlying posterior placenta, but no evidence of abruption or any other abnormality.On examination the patient seemed relaxed with a pulse rate of XOimin, blood pressure 105/ 65 mmHg and temperature 36°C. Her uterus was contracting every 5 min. The fundal height was 26 cm. and vaginal examination showed that the cervix was fully effaced, soft, and 2 cm dilated. An ultrasound scan performed on the labour ward demonstrated a single live fetus with a breech presentation and an estimated weight of 750g. The placenta was clear of the

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Bacteriological study of Amniotic fluid During labor

Cited by 4 publications

References 5 publications

Occurrence of bacteria and polymorphonuclear leukocytes in fetal compartments at parturition; relationships with foal and mare health in the peripartum period

Occurrence of bacteria and polymorphonuclear leukocytes in fetal compartments at parturition; relationships with foal and mare health in the peripartum period

Pathophysiology and Histopathology of Group B Streptococcal Sepsis in Macaca nemestrina Primates Induced after Intraamniotic Inoculation: Evidence for Bacterial Cellular Invasion

Amnionitis caused by Propionibacterium acnes

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