Bacteriological Profile of Ventilator Associated Pneumonia in a Tertiary Care Hospital of South India with Special Reference to Multi Drug Resistant Pathogens

Khelgi, Amit; Prathab, A G

doi:10.20546/ijcmas.2017.611.065

Cited by 3 publications

(4 citation statements)

References 15 publications

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“…The study conducted by Amit Khelgi et al in 2017 at south India discussed the role of gram-negative bacterial etiology in ventilatorassociated pneumonia. 10 This is well correlated with the present study where 98% were gram-negative bacilli and 2% were gram-positive cocci. Among the isolates the most common isolates were Klebsiella pneumoniae (31.31%) and Acinetobacter baumanii (31.31%).…”

Section: Discussionsupporting

confidence: 92%

Bacteriological profile and antimicrobial resistance pattern of ventilator associated pneumonia in tertiary care hospital

Rajesh¹,

Katragadda²,

Ramani³

2021

IJMR

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With an occurrence ranging from 6-52%, ventilator-associated pneumonia (VAP) is the most common ICU acquired infection, accounting for a significant portion of hospital-acquired infections (HAIs). VAP is pneumonia that develops after a period of more than 48 hours of mechanical ventilation or endotracheal intubation. To isolate and identify the potential pathogens causing VAP and to study their antimicrobial susceptibility patterns. Endotracheal aspiration (ETA) or bronchoalveolar lavage (BAL) were collected from patients on mechanical ventilation >48 hours. Bacterial isolates were identified based on culture colony characteristics and biochemical parameters. Antibiotic susceptibility profile was determined for these isolates by Kirby-Bauer disc diffusion method as per Clinical and laboratory Standards Institute (CLSI) 2020 guidelines and studied. The collected data was entered in Excel, and analyzed by using SPSS version 16. Among the isolates, the most common were (31.31%) and (31.31%). These were followed by (22.22%), (7.07%), (3.03%) and (3.03%) and (2.02%).Multi Drug Resistant (MDR) microbes causing VAP are on the increase. The patient population at risk will benefit by the application of the results of this study. The antibiotic resistance pattern of these isolates will aid clinicians in selecting the appropriate antimicrobial agents. Hence, it can lead to decreased mortality and morbidity due to life-threatening VAP.

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Section: Discussionsupporting

confidence: 92%

Bacteriological profile and antimicrobial resistance pattern of ventilator associated pneumonia in tertiary care hospital

Rajesh¹,

Katragadda²,

Ramani³

2021

IJMR

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“…Maximum sensitivity was observed with Colistin, Tigecycline and Minocycline. Our findings were similar to the other studies 6,7,8,9 In last two decades, Gram negative bacteria have become important nosocomial pathogens throughout the world and is a leading problem in treatment owing to its multidrug resistance. Colistin, which is an old antimicrobial agent, is very active against these.…”

Section: Discussionsupporting

confidence: 92%

“…Many studies from India have investigated the causative organisms of VAP. Pseudomonas species, Acinetobacter species, Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus are the common pathogens with varying prevalence and quite often being MDR 6,8,9 . Therefore, the local microbial flora causing VAP needs to be studied and an appropriate therapy based on the early ET aspirate report can reduce the mortality and cost in managing this group of patients Aim…”

Section: Introductionmentioning

confidence: 99%

Bacteriological Profile of Endotracheal Aspirates and their Antibiotic Susceptibility Pattern

Gowda¹,

G.S²,

N.³

et al. 2018

J Pure Appl Microbiol

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Early onset Ventilator associated pneumonia (VAP) is usually less severe, associated with a better prognosis, and is more likely caused by antibiotic-sensitive bacteria. Late-onset VAP, is usually caused by multidrug resistant (MDR) pathogens and is associated with increased morbidity and mortality. Therefore, the local microbial flora causing VAP needs to be studied and appropriate therapy based on the early endotracheal (ET) aspirate culture report can help managing this group of patients. The present study was carried out in the department of Microbiology, JSS Hospital, Mysore from January 2017 to December 2017. Bacterial pathogens and antibiotic resistance pattern of isolates from ET aspirates of patients on mechanical ventilation in Intensive care units were source of data. A total number of 1432 samples were received in the lab for ET aspirate culture. Among these 1432 samples, 1055 showed growth ranging from 10 2 to 10 6 colony forming units/ml (CFU/ml), 124 had no growth at all and 253 had no significant growth (<10 2 CFU/ml) Out of 1055 isolates,1023 were Gram negative bacteria and 32 were Gram positive cocci . Acinetobacter, Pseudomonas and Klebsiella were the major pathogens in our study. Majority of them being MDR, maximum sensitivity was observed for Tigecycline and colistin in these isolates. Knowledge of causative microbial flora of VAP along with information on the susceptibility patterns will help in selection of the appropriate antibiotic for therapeutic use for better outcome.

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“…aureus. 18 A study done by Quartin et al was reported that gram positive pathogens were the predominant isolates (42.7 %). 20 This disparity in the pattern of bacterial isolates may be due to the fact that the studies were done in different geographical areas.…”

Section: Discussionmentioning

confidence: 96%

Microbial isolates and their antimicrobial resistance pattern from endotracheal aspirates: a retrospective observational study over one year at a tertiary care hospital of Bangladesh

et al. 2022

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Background: Emergence of multidrug resistant (MDR) organisms causing ventilator-associated pneumonia (VAP) is an increasing threat with substantial mortality in critically ill patients. Aetiology and treatment of VAP in mechanically ventilated patients can be evaluated by analysis of culture reports periodically for better understanding of microbial isolates and their antimicrobial susceptibility pattern. The present study aimed to analyze the culture and sensitivity pattern of endotracheal aspirates in intensive care unit (ICU) patients. Methods: A hospital-based retrospective study was done in the Department of Microbiology, BIRDEM General Hospital, Dhaka, Bangladesh from January to December, 2019. Data were obtained from the laboratory record book conserved in the Department of Microbiology. Isolates of endotracheal aspirates from 715 patients were identified and their antibiotic susceptibility were (done by standard microbiological methods) recorded. Results: Out of total 715 endotracheal aspirates, growth was obtained from 482 (67.4%) samples. Among the 482 culture positive samples, 714 isolates were identified of which 250 (51.9%) yielded single organism and 232 (48.1%) were double organisms. Among total isolates, 642 (89.9%) were bacteria and 72 (10.1%) were fungi. Gram negative bacilli were mostly isolated organisms (85.6%) followed by fungi (10.1%) and gram positive cocci (4.3%). Acinetobacter sp. (40.6%) was the most prevailing of all isolates followed by Klebsiella sp.(29.4%), Pseudomonas sp. (11.2%), Candida sp. (8.7%), Staph. aureus (3.8%), Esch. coli (2.8%) and Aspergillus sp. (1.3%). Almost all (90-100%) of the Acinetobacter sp., Klebsiella sp., and Esch. coli showed resistance to 3rd generation cephelasporin, aztreonam, amoxicillin-clavulunate and ciprofloxacin and lowest resistance was noted to tigecycline (5.2%, 13% and 0% respectively). Imipenem was found resistant to 97.6%, 77.4% and 30% in Acinetobactersp, Klebsiella sp. and Esch.coli respectively. Resistant pattern of Pseudomonas sp. to ceftazidime (72.5%), aztreonam (81.2%), imipenem (75%), aminoglycosides (70-76%), ciprofloxacin (72.5%), piperacillintazobactum (41.2%) and colistin (11.2%) were also noted. Methicillin-resistant Staph. aureus (MRSA)were 77.8% and 75% Enterococcus sp. showed high level resistance to gentamicin (HLGRE). No vancomycin resistant Staph. aureus(VRSA) or Enterococcus sp. (VRE) was detected in this study. Conclusion: Gram negative isolates were large-scale than any other microorganism. Of them, Acinetobacter sp. was most quotidian followed by Klebsiella sp. Acinetobacter sp. and Klebsiella sp. were highly resistant to different antibiotics including imipenem and piperacillin-tazobactum. High rate of colistin resistant Pseudomonas sp. were also observed. Combined clinical, microbiological and infection control strategies can guide appropriate patient management and antimicrobial stewardship program to combat antibiotic resistance in critical care set up in Bangladesh. BIRDEM Med J 2022; 12(3): 195-200

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Bacteriological Profile of Ventilator Associated Pneumonia in a Tertiary Care Hospital of South India with Special Reference to Multi Drug Resistant Pathogens

Cited by 3 publications

References 15 publications

Bacteriological profile and antimicrobial resistance pattern of ventilator associated pneumonia in tertiary care hospital

Bacteriological profile and antimicrobial resistance pattern of ventilator associated pneumonia in tertiary care hospital

Bacteriological Profile of Endotracheal Aspirates and their Antibiotic Susceptibility Pattern

Microbial isolates and their antimicrobial resistance pattern from endotracheal aspirates: a retrospective observational study over one year at a tertiary care hospital of Bangladesh

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