“…A et al (10) (Klebsiella 62.7%, Ecoli 46.5%).The extensive use of broad spectrum β-lactam antibiotics has led to marked increase in the incidence of Amp C in Gram negative organisms particularly family Enterobacteriaceae. In current study, 1(50%) Klebsiella isolates in which both ESBL and Amp C are co-expressed in the same isolate and 1 (50 %) Escherichia coli isolates were AmpC -lactamase producers similar to Subitha.B et al (22) with Klebsiellasp ( 25%) and Ecoli (11%).All ESBL isolates were sensitive to imipenem (100%) followed by amikacin(77%), piperacillin/tazobactam (46%), meropenem (46), ampicillin (7.7%), chloramphenicol(23%), cefepime (26.92%), ciprofloxacin (23.08%), gentamicin (19.23%), tobramycin (11.54%), kanamycin (7.69%), tetracycline (7.6%) ( (14) (53.6%, 46.4%), Mustafa.M et al (13) (58%,42%), Premalatha. D.E et al (78.5%,21.5%) (24) On the contrary, Kayange .…”