Bacteriological Profile and Antibiotic Sensitivity of Neonatal Septicemia Admitted in Neonatal Intensive Care Unit (NICU) of Dhaka Shishu Hospital

Hossain, M Monir; Yusuf, Mir Mohammad; Kamrunzzaman,; Rahman, Mahbubur; Alam, Jahangir

doi:10.3329/dshj.v35i2.49694

Cited by 3 publications

(3 citation statements)

References 7 publications

(14 reference statements)

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“…In our study, the positivity rates amongst neonates that presented with EOS and LOS were 41(56.9%) and 31(43.1%) respectively, this could have been due to infections asecending from the perineum of the mother or due to poor infection control during the delivery process. This was higher in male (55%) than female (44.4%) as also reported in other studies [30].…”

Section: Discussionsupporting

confidence: 76%

Bacteriological Profile, Antibiotic Susceptibility and Factors Associated with Neonatal Septicaemia at Kilembe Mines Hospital, Kasese District Western Uganda

Zamarano

Musinguzi

Kabajulizi

et al. 2021

Preprint

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Introduction: Neonatal septicaemia is one of the most common leading causes of neonatal morbidity and mortality in developing countries. It is estimated to affect more than 30 million people worldwide annually, potentially leading to 6 million deaths. Objective(s): To determine the prevalence, bacteriological profile, antibiotic susceptibility and factors associated with neonatal septicaemia among neonates seeking medical services at Kilembe mines hospital.Methods: We conducted a descriptive cross-sectional study where blood was drawn from 122 neonates that were seeking medical attention at Kilembe Mines Hospital during the period of July to November 2020. Specimens were inoculated in BHI broth, transported to Fortportal Regional Referral Hospital, plated daily up to 7 days on blood, chocolate, MacConkey agar and incubated in aerobic and 5% carbondioxide. Pure colonies were identified by gram stain, biochemical tests and antibiotic sensitivities obtained by Kirby Bauer disc diffusion method. Statistical significance set at P< 0.05 and logistic regression was used to determine predictors of neonatal septicaemia. Stata (version 14) used for statistical analysis.Results: Blood cultures were positive in 59.0% cases with 55.5% male and 44.4% female. EOS was present in 56.9% and LOS 43.1% of the cases. Gram negative (56.9%) organisms were most implicated with neonatal septicaemia than gram positives ones (43.1%). Gram positive organisms exhibited better susceptibility to amikacin, linezolid and vancomycin but more resistant to ampicillin and gentamicin. Of the aminoglycosides, amikacin exhibited a verge over netilmicin and gentamicin against gram negative isolates. Risk factors of neonatal septicaemia were mother’s age of ≥25 years, employed mothers, tertiary-level of education, SVD, ANC attendance of ≥4 times, UTI during pregnancy, PROMS, foul Smelling liquor, urban residence, neonatal birth weight of ≥2500g, Apgar score 1st and 5th min ≥6 and resuscitation.Conclusion: Multi-drug resistant organisms were isolated. Therefore caution is required in selection of antibiotic therapy and avoid empirical treatment.

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Section: Discussionsupporting

confidence: 76%

Bacteriological Profile, Antibiotic Susceptibility and Factors Associated with Neonatal Septicaemia at Kilembe Mines Hospital, Kasese District Western Uganda

Zamarano

Musinguzi

Kabajulizi

et al. 2021

Preprint

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“…Studies from Bangladesh and India showed Meropenem and Imipenem sensitivity of only about 38% and 70(92.1%) to Klebsiella. 27,28 In another study, Acinetobacter was resistant to Imipenem in 7(100%) cases. 27 The study showed 95% resistance of Acinetobacter to Meropenem.…”

Section: Resultsmentioning

confidence: 96%

“…27,28 In another study, Acinetobacter was resistant to Imipenem in 7(100%) cases. 27 The study showed 95% resistance of Acinetobacter to Meropenem. 27 Low birth weight and prematurity requiring long NICU stay, need of mechanical ventilation in more cases and use of central catheters are the reasons that the babies in NICU are at more risk of getting sepsis with multidrug-resistant microorganisms.…”

Section: Resultsmentioning

confidence: 96%

Association of thrombocytopenia with specific organism and mortality in neonatal sepsis

Chalise

Mishra

Kansakar

et al. 2021

J Patan Acad Health Sci

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Introduction: Neonatal sepsis is one of the leading causes of mortality worldwide. Knowing the association of thrombocytopenia to the specific organism can help to choose the correct antibiotic before a culture sensitivity report becomes available. Hence, this study was planned to find out if thrombocytopenia is associated with any specific type of organism in neonatal sepsis and higher mortality. Method: It was a retrospective observational study done at the neonatal intensive care unit at Patan Hospital. The samples were taken over three years, from April 2018 to March 2021. All culture-positive sepsis within the study period were included. The cases whose files were missing were excluded. Neonatal sepsis was defined as cases where a blood culture was positive for the organism. The data was analyzed using SPSS 16. Result: There were 51 cases whose analysis was done. Klebsiella 25(49.02%) and Acinetobacter 11(21.57%) were the most common organisms. Fifty-nine percent of cases had thrombocytopenia among which 5(10%), 6(12%), and 19(37%) had mild, moderate, and severe thrombocytopenia, respectively. Klebsiella sepsis was significantly associated with thrombocytopenia (p-value 0.001). The sensitivity of Klebsiella to Meropenem and Colistin was 70% and 100% respectively. Mortality was not associated with thrombocytopenia. Conclusion: In the study, thrombocytopenia was associated with Klebsiella sepsis in neonates. Hence, in thrombocytopenic patients with clinical suspicion of sepsis, proper antibiotics to cover Klebsiella should be started empirically till a blood culture report becomes available.

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Bacteriological profile, antibiotic susceptibility and factors associated with neonatal Septicaemia at Kilembe mines hospital, Kasese District Western Uganda

et al. 2021

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Introduction Neonatal septicaemia is one of the most common leading causes of neonatal morbidity and mortality in developing countries. It is estimated to affect more than 30 million people worldwide annually, potentially leading to 6 million deaths. Objective(s) To determine the prevalence, bacteriological profile, antibiotic susceptibility and factors associated with neonatal septicaemia among neonates suspected to sepsis at Kilembe mines hospital. Methods We conducted a descriptive cross-sectional study, where purposive sampling technique was used and blood was drawn from 122 neonates suspected to sepsis attending Kilembe Mines Hospital during the period (July to November 2020). Specimens were inoculated in Brain heart infusion broth, transported to Fortportal Regional Referral Hospital, plated daily up to 7 days on blood, chocolate, MacConkey agar and incubated in aerobic and 5% carbondioxide. Pure colonies were identified by Gram stain, biochemical tests and antibiotic sensitivities obtained by Kirby Bauer disc diffusion method. Associations were tested using Chi square with Fisher’s exact or Yates correction tests where necessary and statistical significance was set at P < 0.05. Stata (version 14) used for statistical analysis. Results Blood cultures were positive in 59.0% cases with 55.5% male and 44.4% female. EOS was present in 56.9% and LOS 43.1% of the cases. Gram negative (56.9%) organisms were most implicated with neonatal septicaemia than Gram positives ones (43.1%). Gram positive organisms exhibited better susceptibility to amikacin, linezolid and vancomycin but more resistant to ampicillin and gentamicin. Of the aminoglycosides, amikacin exhibited a verge over netilmicin and gentamicin against Gram negative isolates. Risk factors of neonatal septicaemia were mother’s age of ≥25 years, employed mothers, tertiary-level of education, SVD, ANC attendance of ≥4 times, UTI during pregnancy, PROMS, foul Smelling liquor, urban residence, neonatal birth weight of ≥2500 g, Apgar score 1st and 5th min ≥6 and resuscitation. Conclusion Multi-drug resistant organisms were isolated. Therefore caution is required in selection of antibiotic therapy and avoid empirical treatment.

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Bacteriological Profile and Antibiotic Sensitivity of Neonatal Septicemia Admitted in Neonatal Intensive Care Unit (NICU) of Dhaka Shishu Hospital

Cited by 3 publications

References 7 publications

Bacteriological Profile, Antibiotic Susceptibility and Factors Associated with Neonatal Septicaemia at Kilembe Mines Hospital, Kasese District Western Uganda

Bacteriological Profile, Antibiotic Susceptibility and Factors Associated with Neonatal Septicaemia at Kilembe Mines Hospital, Kasese District Western Uganda

Association of thrombocytopenia with specific organism and mortality in neonatal sepsis

Bacteriological profile, antibiotic susceptibility and factors associated with neonatal Septicaemia at Kilembe mines hospital, Kasese District Western Uganda

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