Bacteriological Profile and Antibiotic Sensitivity Pattern of Isolates of Neonatal Septicemia

Abstract

BACKGROUND: In India neonatal septicemia is a leading cause of mortality. Regionwise variation regarding the predominant pathogens and their antibiotic sensitivity pattern were observed. The study was undertaken to know the pattern in this region. METHOD: The study comprised of 210 clinically suspected cases of neonatal septicemia admitted in the neonatal intensive care unit. Two to three ml blood was collected aseptically in Trypticase Soya broth and isolates were identified. RESULT: Growth was obtained in 106(50.47%) samples. Gram negative organisms were predominant. Multidrug resistant was observed in most of the organisms. CONCLUSION: As there was species-wise variation in antibiotic resistant pattern of organisms, we recommend antibiotic sensitivity should be done before starting antibiotics. As for as possible, first and second line antibiotics should be included in primary sensitivity testing to avoid delay in treatment and inappropriate use of antibiotics.

Clinical and bacteriological study of neonatal septicaemia in a tertiary care hospital

“…2 In present study, the most frequently isolated organism was Klebsiella pneumoniae 54 (26.34%) followed by S. aureus 36 (17.56%). Our findings were similar to Muley VA et al 18 K. pneumoniae was reported as a predominant pathogen in NNPD Report 2002-2003 and also by Sharma CM et al, Iregbu et al, Chelliah A et al and Tankhiwale SS et al 3,11,[27][28][29] K.pneumoniae and S. aureus can survive in the environment for a relatively long time and fairly widely distributed in the hospital environment and therefore have the potential for being transmitted from the environment to the patients through practices that breach infection control measures.…”

“…Similar findings were made by Muley VA et al and Tankhiwale et al 18,27 The probable reasons being, new-borns most probably acquire these gram-negative rods from the vaginal and faecal flora of the mother and the environment where the delivery occurs. 28 The increased susceptibility of neonates to gram negative bacteria may be explained by the fact that antibodies against these organisms are primarily IgM type which do not transfer passively through placenta and are at very low level in blood at birth (about 5% of adult value) and reaches the adult level by 2 years of age.…”

“…Similar antibiotic sensitivity pattern had been reported by Tankhiwale SS et al and Singh N et al 27,32 …”