Bacteriologic Findings Associated with Chronic Bacterial Maxillary Sinusitis in Adults

Finegold, Sydney M.; Flynn, M. J.; Rose, Fredrick; Jousimies‐Somer, Hannele; Jakielaszek, Charles; McTeague, M.; Wexler, Hannah M.; Berkowitz, Elchonon M.; Wynne, Brian

doi:10.1086/341899

Cited by 107 publications

(63 citation statements)

References 9 publications

(23 reference statements)

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“…These species are rarely cultured from clinical samples because of their fastidious nature, which may have contributed to the fact that they were detected and identified here only by molecular methods. Recent results from a multicentre study corroborate our findings by showing that Granulicatella species are associated with chronic maxillary sinusitis and may contribute to antibiotic treatment failure (Finegold et al, 2002).…”

Section: Discussionsupporting

confidence: 84%

Molecular analysis of bacterial flora associated with chronically inflamed maxillary sinuses

Paju

Bernstein

Haase

et al. 2003

Journal of Medical Microbiology

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Chronic maxillary sinusitis is a chronic inflammatory condition in which the role of microbial infection remains undefined. Bacteria have been isolated from chronically inflamed sinuses; however, their role in the chronicity of inflammation is unknown. The objective of this study was to determine whether bacteria are present in clinical samples from chronic maxillary sinusitis and to assess the diversity of the flora present. Washes and/or tissue samples from endoscopic sinus surgery on 11 patients with chronic maxillary sinusitis were subjected to PCR amplification of bacterial 16S rDNA using three universal primer pairs, followed by cloning and sequencing. The samples were also assessed for the presence of bacteria and fungi by conventional culture methods. Viable bacteria and/or bacterial 16S rDNA were detected from maxillary sinus samples of five of the 11 patients examined (45 %). Three sinus samples were positive by both PCR and culture methods, one was positive only by PCR, and one only by culture. Thirteen bacterial species were identified: Abiotrophia defectiva, Enterococcus avium, Eubacterium sp., Granulicatella elegans, Neisseria sp., Prevotella sp., Pseudomonas aeruginosa, Serratia marcescens, Staphylococcus aureus, Stenotrophomonas maltophilia, Streptococcus gordonii, Streptococcus mitis/Streptococcus oralis and Streptococcus sp. Fungi were not detected. In one patient Streptococcus mitis/Streptococcus oralis, and in another patient Pseudomonas aeruginosa, were detected from both the sinus and the oral cavity using species-specific PCR primers. These results suggest that both aerobic and anaerobic bacteria can be detected in nearly half of chronic maxillary sinusitis cases.

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Section: Discussionsupporting

confidence: 84%

Molecular analysis of bacterial flora associated with chronically inflamed maxillary sinuses

Paju

Bernstein

Haase

et al. 2003

Journal of Medical Microbiology

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“…The commonest bacterial pathogens are Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis . If the bacterial ARS does not dissipate, members of the anaerobic oropharyngeal flora and Staphylococcus aureus emerge as a pathogens 2, 8, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25…”

Section: Microbiologymentioning

confidence: 99%

The role of antibiotics in pediatric chronic rhinosinusitis

Brook

2017

Laryngoscope Investig Oto

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ObjectivesPresenting the role of antibiotics in pediatric chronic rhinosinusitis based on its pathophysiology and microbiology.Data sourceReview of the literature searching PubMed for microbiology and treatment of pediatric chronic rhinosinusitis.ResultsChronic rhinosinusitis (CRS) is an inflammatory condition of the paranasal sinuses that persists for 12 weeks or longer, despite medical management. The microbiology of rhinosinusitis evolves through several stages. The early phase (acute) is generally caused by a virus that may be followed by an aerobic bacterial infection in 2% to 10% of patients. Aerobic (Staphylococcus aureus) and anaerobic (Prevotella and Fusobacteria) members of the oral flora emerge as predominant sinus cavity isolates. Antimicrobials are one component of comprehensive medical and surgical management for this disorder. Because most of these infections are polymicrobial and many include beta‐lactamase producing aerobic and anaerobic organisms, amoxicillin‐clavulanate is the first‐line regimen for most patients. Clindamycin is adequate for penicillin‐allergic children and is also generally appropriate for methicillin resistant Staphylococcus aureus treatment is administered for at least three weeks and may be extended for up to 10 weeks in refractory cases. A culture preferably from the sinus cavity should be obtained from individuals who have not shown improvement or deteriorated despite therapy.ConclusionsAntimicrobial therapy of pediatric chronic rhinosinusitis should be adequate against the potential aerobic and anaerobic pathogens.Level of Evidence7.

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“…Sinusitis is a complication of viral upper respiratory tract infection, estimated to occur following ϳ7% of episodes in children and less often in adults. Samples obtained by sinus puncture or endoscopy reveal that H. influenzae is an important pathogen in both acute and chronic sinusitis (6,7,11). Pneumococcal conjugate vaccines appear to have resulted in a relative increase in H. influenzae as a cause of sinusitis (7).…”

Section: Clinical Manifestations Of H Influenzae Infectionsmentioning

confidence: 99%

Haemophilus influenzae Infections in the H. influenzae Type b Conjugate Vaccine Era

2011

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The widespread use of Haemophilus influenzae type b (Hib) conjugate vaccines has nearly eradicated invasive Hib disease where the vaccines are used. This success was accompanied by a shift in capsular serotypes of invasive H. influenzae disease, with nontypeable strains replacing type b strains as the most common bloodstream isolate, but there is no convincing evidence of a true increase in the incidence of non-serotype b invasive infections. H. influenzae causes predominantly mucosal infections. The introduction of vaccines for otitis media and global shifts in antimicrobial susceptibility emphasize the importance of continued surveillance of H. influenzae colonization and disease patterns.

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Bacteriologic Findings Associated with Chronic Bacterial Maxillary Sinusitis in Adults

Cited by 107 publications

References 9 publications

Molecular analysis of bacterial flora associated with chronically inflamed maxillary sinuses

Molecular analysis of bacterial flora associated with chronically inflamed maxillary sinuses

The role of antibiotics in pediatric chronic rhinosinusitis

Haemophilus influenzae Infections in the H. influenzae Type b Conjugate Vaccine Era

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