Bacteriocin-like inhibitory substances from Campylobacter spp.

Workman, Suzanne N.; Been, Floyd E.; Crawford, Simera R.; Lavoie, Marie

doi:10.1007/s10482-007-9208-9

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…Other studies showed an inhibitory effect of P. intermedia , isolated from the subgingival plaque of HIV-infected patients, on the formation of C. albicans germ tubes ( Nair et al., 2001 ). A similar effect was also observed for another bacterium from the group of bridging colonizers— Campylobacter —that through the secretion of bacteriocin-like substances with antimicrobial activity inhibited the growth of C. albicans laboratory strain ATCC 44859 as detected using measurements of the zone of inhibition ( Workman et al., 2007 ).…”

Section: Albicans Ability To Form a Multispecies Biofilm Community In Periodontal Diseasessupporting

confidence: 57%

The Role of Candida albicans Virulence Factors in the Formation of Multispecies Biofilms With Bacterial Periodontal Pathogens

Satała

González-González

Smolarz

et al. 2022

Front. Cell. Infect. Microbiol.

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Periodontal disease depends on the presence of different microorganisms in the oral cavity that during the colonization of periodontal tissues form a multispecies biofilm community, thus allowing them to survive under adverse conditions or facilitate further colonization of host tissues. Not only numerous bacterial species participate in the development of biofilm complex structure but also fungi, especially Candida albicans, that often commensally inhabits the oral cavity. C. albicans employs an extensive armory of various virulence factors supporting its coexistence with bacteria resulting in successful host colonization and propagation of infection. In this article, we highlight various aspects of individual fungal virulence factors that may facilitate the collaboration with the associated bacterial representatives of the early colonizers of the oral cavity, the bridging species, and the late colonizers directly involved in the development of periodontitis, including the “red complex” species. In particular, we discuss the involvement of candidal cell surface proteins—typical fungal adhesins as well as originally cytosolic “moonlighting” proteins that perform a new function on the cell surface and are also present within the biofilm structures. Another group of virulence factors considered includes secreted aspartic proteases (Sap) and other secreted hydrolytic enzymes. The specific structure of the candidal cell wall, dynamically changing during morphological transitions of the fungus that favor the biofilm formation, is equally important and discussed. The non-protein biofilm-composing factors also show dynamic variability upon the contact with bacteria, and their biosynthesis processes could be involved in the stability of mixed biofilms. Biofilm-associated changes in the microbe communication system using different quorum sensing molecules of both fungal and bacterial cells are also emphasized in this review. All discussed virulence factors involved in the formation of mixed biofilm pose new challenges and influence the successful design of new diagnostic methods and the application of appropriate therapies in periodontal diseases.

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Section: Albicans Ability To Form a Multispecies Biofilm Community In Periodontal Diseasessupporting

confidence: 57%

The Role of Candida albicans Virulence Factors in the Formation of Multispecies Biofilms With Bacterial Periodontal Pathogens

Satała

González-González

Smolarz

et al. 2022

Front. Cell. Infect. Microbiol.

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“…This correlation is in agreement with the findings of Navazesh et al [69], who showed that antiretroviral therapy increased the risk for recovering bacteria (including Campylobacter species) with a concomitant decrease in the recovery rate of Candida , in HIV-infected women. Moreover, Workman et al [70] reported that proteins secreted by Campylobacter inhibit the growth of C. albicans . The clinical relevance of this correlation remains to be investigated.…”

Section: Discussionmentioning

confidence: 99%

Oral Mycobiome Analysis of HIV-Infected Patients: Identification of Pichia as an Antagonist of Opportunistic Fungi

et al. 2014

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Oral microbiota contribute to health and disease, and their disruption may influence the course of oral diseases. Here, we used pyrosequencing to characterize the oral bacteriome and mycobiome of 12 HIV-infected patients and matched 12 uninfected controls. The number of bacterial and fungal genera in individuals ranged between 8–14 and 1–9, among uninfected and HIV-infected participants, respectively. The core oral bacteriome (COB) comprised 14 genera, of which 13 were common between the two groups. In contrast, the core oral mycobiome (COM) differed between HIV-infected and uninfected individuals, with Candida being the predominant fungus in both groups. Among Candida species, C. albicans was the most common (58% in uninfected and 83% in HIV-infected participants). Furthermore, 15 and 12 bacteria-fungi pairs were correlated significantly within uninfected and HIV-infected groups, respectively. Increase in Candida colonization was associated with a concomitant decrease in the abundance of Pichia, suggesting antagonism. We found that Pichia spent medium (PSM) inhibited growth of Candida, Aspergillus and Fusarium. Moreover, Pichia cells and PSM inhibited Candida biofilms (P = .002 and .02, respectively, compared to untreated controls). The mechanism by which Pichia inhibited Candida involved nutrient limitation, and modulation of growth and virulence factors. Finally, in an experimental murine model of oral candidiasis, we demonstrated that mice treated with PSM exhibited significantly lower infection score (P = .011) and fungal burden (P = .04) compared to untreated mice. Moreover, tongues of PSM-treated mice had few hyphae and intact epithelium, while vehicle- and nystatin-treated mice exhibited extensive fungal invasion of tissue with epithelial disruption. These results showed that PSM was efficacious against oral candidiasis in vitro and in vivo. The inhibitory activity of PSM was associated with secretory protein/s. Our findings provide the first evidence of interaction among members of the oral mycobiota, and identifies a potential novel antifungal.

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“…It is supposed that many bacteria belonging to Proteobacteria including Escherichia coli and Pseudomonas aeruginosa are antagonistic to C. albicans. [67][68][69] In fact, the presence of Enterobacteriaceae is essential for the modulation of colitis with overgrown C. albicans. 70 Furthermore, there are also several other microbiota which might play non-negligible roles in colitis progress in this study, such as Campilobacterota, Actinobacteriota and Deferribacterota.…”

Section: Food and Functionmentioning

confidence: 99%

Sodium houttuyfonate derived fromHouttuynia cordataThunb improves intestinal malfunctionviamaintaining gut microflora stability inCandida albicansovergrowth aggravated ulcerative colitis

Cheng

Chen

et al. 2023

Food Funct.

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Bacteriocin-like inhibitory substances from Campylobacter spp.

Cited by 5 publications

References 5 publications

The Role of Candida albicans Virulence Factors in the Formation of Multispecies Biofilms With Bacterial Periodontal Pathogens

The Role of Candida albicans Virulence Factors in the Formation of Multispecies Biofilms With Bacterial Periodontal Pathogens

Oral Mycobiome Analysis of HIV-Infected Patients: Identification of Pichia as an Antagonist of Opportunistic Fungi

Sodium houttuyfonate derived fromHouttuynia cordataThunb improves intestinal malfunctionviamaintaining gut microflora stability inCandida albicansovergrowth aggravated ulcerative colitis

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