Bacteriocin‐capped silver nanoparticles for enhanced antimicrobial efficacy against food pathogens

Sidhu, Parveen Kaur; Nehra, Kiran

doi:10.1049/iet-nbt.2019.0323

Cited by 28 publications

(18 citation statements)

References 34 publications

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“…Other studies have shown that the combination of bacteriocins and AgNPs is an effective treatment against ESKAPE pathogens [ 170 , 171 , 172 , 173 ]. For example, Gomaa used a bacteriocin extracted from Lactobacillus paracasei that, in combination with AgNPs, exhibited a more potent synergistic bactericidal effect than individual treatments against clinical MDR isolates of S. aureus , P. aeruginosa , K. pneumoniae , E. coli , and Staphylococcus pyogenes [ 135 ].…”

Section: New Therapeutic Strategies: Combinatorial Treatmentsmentioning

confidence: 99%

Nanomaterials-Based Combinatorial Therapy as a Strategy to Combat Antibiotic Resistance

et al. 2022

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Since the discovery of antibiotics, humanity has been able to cope with the battle against bacterial infections. However, the inappropriate use of antibiotics, the lack of innovation in therapeutic agents, and other factors have allowed the emergence of new bacterial strains resistant to multiple antibiotic treatments, causing a crisis in the health sector. Furthermore, the World Health Organization has listed a series of pathogens (ESKAPE group) that have acquired new and varied resistance to different antibiotics families. Therefore, the scientific community has prioritized designing and developing novel treatments to combat these ESKAPE pathogens and other emergent multidrug-resistant bacteria. One of the solutions is the use of combinatorial therapies. Combinatorial therapies seek to enhance the effects of individual treatments at lower doses, bringing the advantage of being, in most cases, much less harmful to patients. Among the new developments in combinatorial therapies, nanomaterials have gained significant interest. Some of the most promising nanotherapeutics include polymers, inorganic nanoparticles, and antimicrobial peptides due to their bactericidal and nanocarrier properties. Therefore, this review focuses on discussing the state-of-the-art of the most significant advances and concludes with a perspective on the future developments of nanotherapeutic combinatorial treatments that target bacterial infections.

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Section: New Therapeutic Strategies: Combinatorial Treatmentsmentioning

confidence: 99%

Nanomaterials-Based Combinatorial Therapy as a Strategy to Combat Antibiotic Resistance

et al. 2022

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“…Bacteriocins from Lactobacillus spp. Bac4463 and Bac22 capped with silver nanoparticles were reported to enhance the AMA against food pathogens S. aureus and Shigella flexneri (Sidhu and Nehra 2020).…”

Section: Silver Nanoparticlesmentioning

confidence: 99%

Bacteriocin nanoconjugates: boon to medical and food industry

Sulthana

Archer

2021

J of Applied Microbiology

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SummaryResistance to antibiotics is an ongoing problem in the biomedical industry. Developing active, alternative drug therapies would reduce our reliance on antibiotics that induce resistance in micro-organisms. To date, bacteriocins and antimicrobial peptides have shown a positive outcome as antibiotic substitutes and synergists apart from phage therapy, antibodies and probiotics. Bacteriocins are proteinaceous antimicrobial peptides synthesized by lactic acid bacteria extensively used as bio-preservatives and alternative to traditional antibiotics to overcome the problem of drug-resistant pathogens. Nonetheless, the use of bacteriocins has several limitations such as limited antimicrobial spectrum, requiring high dose, sensitivity to proteolytic enzymes, etc. Nanoparticles are one of the promising area of research explored to improve antimicrobial spectrum of bacteriocins. This review therefore highlights the recent developments and research pertaining to use of nanoparticles and bacteriocin conjugates to tackle the resistance crisis as well as its applications in food industry.

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“…To combat these limitations, research is now-a-days heading in the direction towards combining two or more classes of bacteriocins that aids in checking their efficacy as an improved/better preservative. Additionally, bacteriocins are also being conjugated with nanoparticles to increase their antimicrobial spectrum and for efficient delivery in target cells [30,40,64,65]. These advancements are bound to contribute more towards new inventions and applications in food sector.…”

Section: Potential Applications Of Bacteriocins In Food Sectormentioning

confidence: 99%

Bacteriocins of Lactic Acid Bacteria as Potent Antimicrobial Peptides against Food Pathogens

Sidhu¹,

Nehra²

2021

Biomimetics

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An ever-growing demand for food products with minimal chemical additives has generated a necessity for exploring new alternatives for food preservation. In this context, more recently, bacteriocins, the peptides having antimicrobial property, synthesized ribosomally by numerous bacteria have been attracting a lot of attention. They are known to possess the potential to restrict the growth of microorganisms causing food spoilage without causing any harm to the bacteria themselves owing to the presence of self-defensive proteins. In particular, the bacteriocins of lactic acid bacteria have been considered harmless and safe for consumption and are indicated to evade the development of unwanted bacteria. Use of bacteriocins as biopreservatives has been studied in various food industries, and they have been established to elevate the shelf life of minimally processed food items by exerting killing mechanism. They restrict the growth of undesirable bacteria by breaking the target cell membrane and finally resulting into pore formation. The current article provides an insight on bacteriocins of lactic acid bacteria, their biosynthesis, mechanism of action, and promising applications of these antimicrobial peptides in the food sector.

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Bacteriocin‐capped silver nanoparticles for enhanced antimicrobial efficacy against food pathogens

Cited by 28 publications

References 34 publications

Nanomaterials-Based Combinatorial Therapy as a Strategy to Combat Antibiotic Resistance

Nanomaterials-Based Combinatorial Therapy as a Strategy to Combat Antibiotic Resistance

Bacteriocin nanoconjugates: boon to medical and food industry

Bacteriocins of Lactic Acid Bacteria as Potent Antimicrobial Peptides against Food Pathogens

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