Bacteriocin-Based Synergetic Consortia: a Promising Strategy to Enhance Antimicrobial Activity and Broaden the Spectrum of Inhibition

Soltani, Samira; Biron, Éric; Said, Laila Ben; Subirade, Muriel; Fliss, Ismaı̈l

doi:10.1128/spectrum.00406-21

Cited by 22 publications

(12 citation statements)

References 46 publications

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“…These metabolic products can also prevent biofilm formation by altering the hydrophobic characteristics of the bacterial surface and decreasing surface tension and, consequently, its adhesion ability [ 25 ]. Bacteriocins are ribosomally synthesised proteins or peptides with antibacterial activity [ 40 , 41 ]. For example, nisin, derived from Lactococcus lactis , has been approved for its antimicrobial activity against several foodborne microorganisms by the WHO and the FDA and is widely used as a food preservative [ 25 , 31 ].…”

Section: Biofilm Prevention and Control Strategies In The Food Industrymentioning

confidence: 99%

Use of Probiotics to Control Biofilm Formation in Food Industries

et al. 2023

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Microorganisms tend to adhere to food contact surfaces and form biofilms, which serve as reservoirs for bacteria that can contaminate food. As part of a biofilm, bacteria are protected from the stressful conditions found during food processing and become tolerant to antimicrobials, including traditional chemical sanitisers and disinfectants. Several studies in the food industry have shown that probiotics can prevent attachment and the consequent biofilm formation by spoilage and pathogenic microorganisms. This review discusses the most recent and relevant studies on the effects of probiotics and their metabolites on pre-established biofilms in the food industry. It shows that the use of probiotics is a promising approach to disrupt biofilms formed by a large spectrum of foodborne microorganisms, with Lactiplantibacillus and Lacticaseibacillus being the most tested genera, both in the form of probiotic cells and as sources of cell-free supernatant. The standardisation of anti-biofilm assays for evaluating the potential of probiotics in biofilm control is of extreme importance, enabling more reliable, comparable, and predictable results, thus promoting significant advances in this field.

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Section: Biofilm Prevention and Control Strategies In The Food Industrymentioning

confidence: 99%

Use of Probiotics to Control Biofilm Formation in Food Industries

et al. 2023

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“…This raises the likelihood that the use of multiple narrow-spectrum SPBs targeting different mechanisms could have synergistic and favorable microbial killing profiles and reduce the likelihood of resistance development. Some recent studies suggest this phenomenon (131,132). Alternatively, a combination of bacterial AMPs with HDPs could also show synergistic activities and provide a favorable microbial killing profile, as recently shown by Bitschar et al (99).…”

Section: Perspectives and Challengesmentioning

confidence: 86%

Microbial derived antimicrobial peptides as potential therapeutics in atopic dermatitis

et al. 2023

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Atopic dermatitis (AD) is a common chronic inflammatory skin disease that significantly affects the patient’s quality of life. A disrupted skin barrier, type 2 cytokine-dominated inflammation, and microbial dysbiosis with increased Staphylococcus aureus colonization are critical components of AD pathogenesis. Patients with AD exhibit decreased expression of antimicrobial peptides (AMPs) which is linked to increased colonization by Staphylococcus aureus. The skin microbiome itself is a source of several AMPs. These host- and microbiome-derived AMPs define the microbial landscape of the skin based on their differential antimicrobial activity against a range of skin microbes or their quorum sensing inhibitory properties. These are particularly important in preventing and limiting dysbiotic colonization with Staphylococcus aureus. In addition, AMPs are critical for immune homeostasis. In this article, we share our perspectives about the implications of microbial derived AMPs in AD patients and their potential effects on overlapping factors involved in AD. We argue and discuss the potential of bacterial AMPs as therapeutics in AD.

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“…EDTA acts by promoting the release of the LPS layer and synergistically potentiates the antimicrobial activity of bacteriocins, as reviewed by Prudêncio et al [68]. Recent studies report the use of bacteriocins with other compounds, as verifed by Soltani et al [61] that verifed the synergistic efect of using Pediocin PA-1 bacteriocins combined with citric acid and/or lactic acid and which inhibited Gram-negative strains such as Aeromonas hydrophila and Klebsiella pneumoniae. In another study by Wang et al [69] verifed the synergistic efect of pediocin PA-1 with lactic acid which also inhibited the Gram-negativeA.…”

Section: Identified Bioprotection Mechanisms Of Labmentioning

confidence: 98%

Strategies for the Development of Bioprotective Cultures in Food Preservation

Souza

Martins

Moreira

et al. 2022

International Journal of Microbiology

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Consumers worldwide are increasingly demanding food with fewer ingredients, preferably without chemical additives. The trend called “Clean Label” has stimulated the development and commercialization of new types of bioprotective bacterial cultures. These bacteria are not considered new, and several cultures have been available on the market. Additionally, new bioprotective bacteria are being identified to service the clean label trend, extend the shelf life, and, mainly, improve the food safety of food. In this context, the lactic acid bacteria (LAB) have been extensively prospected as a bioprotective culture, as they have a long history in food production and their antimicrobial activity against spoilage and pathogenic microorganisms is well established. However, to make LAB cultures available in the market is not that easy, the strains should be characterized phenotypically and genotypically, and studies of safety and technological application are necessary to validate their bioprotection performance. Thus, this review presents information on the bioprotection mechanisms developed by LAB in foods and describes the main strategies used to identify and characterize bioprotective LAB with potential application in the food industry.

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Bacteriocin-Based Synergetic Consortia: a Promising Strategy to Enhance Antimicrobial Activity and Broaden the Spectrum of Inhibition

Abstract: Reuterin and bacteriocins, including microcin J25, pediocin PA-1, nisin were produced and purified with >90% purity. Using the broth-based checkerboard assay the interaction between these compounds (synergetic, additive, or antagonistic) was assessed.

Cited by 22 publications

References 46 publications

Use of Probiotics to Control Biofilm Formation in Food Industries

Use of Probiotics to Control Biofilm Formation in Food Industries

Microbial derived antimicrobial peptides as potential therapeutics in atopic dermatitis

Strategies for the Development of Bioprotective Cultures in Food Preservation

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