Bacteriocin: A new strategic antibiofilm agent in food industries

Kirtonia, Kohima; Salauddin, Molla; Bharadwaj, Kaushik Kumar; Pati, Siddhartha; Dey, Ankita; Shariati, Mohammad Ali; Tilak, Vijay Kumar; Kuznetsova, Еlena; Sarkar, Tanmay

doi:10.1016/j.bcab.2021.102141

Cited by 27 publications

(9 citation statements)

References 121 publications

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“…Over the years various, selective pressures on pathogenic bacteria have resulted in the employment of different ways to adapt various types of environmental nooks. One such adaptive approach is formation of biofilm, which is a consortia of bacterial cells that remain embedded within a self-secreted extracellular polymeric substance (EPS) helping in the process of surface attachment [ 1 , 2 , 3 ]. QS plays a pivotal role in the development of biofilm [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Phytocompound Mediated Blockage of Quorum Sensing Cascade in ESKAPE Pathogens

et al. 2022

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Increased resistance of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter sp. (ESKAPE) pathogens against various drugs has enhanced the urge for the development of alternate therapeutics. Quorum sensing (QS) is a density dependent cell-to-cell communication mechanism responsible for controlling pathogenicity with the regulation of gene expression. Thus, QS is considered a potential target for the development of newer anti-biofilm agents that do not depend on the utilization of antibiotics. Compounds with anti-QS effects are known as QS inhibitors (QSIs), and they can inhibit the QS mechanism that forms the major form in the development of bacterial pathogenesis. A diverse array of natural compounds provides a plethora of anti-QS effects. Over recent years, these natural compounds have gained importance as new strategies for combating the ESKAPE pathogens and inhibiting the genes involved in QS. Different pharmacognostical and pharmacological studies have been carried out so far for identification of novel drugs or for the discovery of their unique structures that may help in developing more effective anti-biofilm therapies. The main objective of this review is to discuss the various natural compounds, so far identified and their employed mechanisms in hindering the genes responsible for QS leading to bacterial pathogenesis.

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Section: Introductionmentioning

confidence: 99%

Phytocompound Mediated Blockage of Quorum Sensing Cascade in ESKAPE Pathogens

et al. 2022

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“…Based on evolution, the synthesis of one or more than one bacteriocin is found to be extremely advantageous. The elimination of competing organisms from the environmental context is found to be optimistic for the species’ diversity and expeditious bacterial growth ( Dykes, 1995 ; Kirtonia et al, 2021 ). It has been observed that low molecular weight antibiotics like tetracyclines, bacteriophage, bacteriolytic enzymes, hydrogen peroxide, toxins, lytic agents, and some metabolic by-products showed equivalent functions of bacteriocins.…”

Section: Introductionmentioning

confidence: 99%

Bacteriocin: A natural approach for food safety and food security

Lahiri

Nag

Dutta

et al. 2022

Front. Bioeng. Biotechnol.

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The call to cater for the hungry is a worldwide problem in the 21st century. Food security is the utmost prime factor for the increasing demand for food. Awareness of human health when using chemical preservatives in food has increased, resulting in the use of alternative strategies for preserving food and enhancing its shelf-life. New preservatives along with novel preservation methods have been instigated, due to the intensified demand for extended shelf-life, along with prevention of food spoilage of dairy products. Bacteriocins are the group of ribosomally synthesized antimicrobial peptides; they possess a wide range of biological activities, having predominant antibacterial activity. The bacteriocins produced by the lactic acid bacteria (LAB) are considered to be of utmost importance, due to their association with the fermentation of food. In recent times among various groups of bacteriocins, leaderless and circular bacteriocins are gaining importance, due to their extensive application in industries. These groups of bacteriocins have been least studied as they possess peculiar structural and biosynthetic mechanisms. They chemically possess N-to-C terminal covalent bonds having a predominant peptide background. The stability of the bacteriocins is exhibited by the circular structure. Up till now, very few studies have been performed on the molecular mechanisms. The structural genes associated with the bacteriocins can be combined with the activity of various proteins which are association with secretion and maturation. Thus the stability of the bacteriocins can be used effectively in the preservation of food for a longer period of time. Bacteriocins are thermostable, pH-tolerant, and proteolytically active in nature, which make their usage convenient to the food industry. Several research studies are underway in the domain of biopreservation which can be implemented in food safety and food security.

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“…The common type of interaction observed between the electrode and the electroactive bacteria in BES is biofilms. Biofilms are a group of aggregated microorganisms composed of a single or more than one type of microbes (Lahiri et al, 2019;Kirtonia et al, 2021). In this context, the presence of diverse microbial communities and the synergistic interaction among them tend to play a crucial role (Nag et al, 2021a).…”

Section: Introductionmentioning

confidence: 99%

Microbiomics for enhancing electron transfer in an electrochemical system

et al. 2022

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In microbial electrochemical systems, microorganisms catalyze chemical reactions converting chemical energy present in organic and inorganic molecules into electrical energy. The concept of microbial electrochemistry has been gaining tremendous attention for the past two decades, mainly due to its numerous applications. This technology offers a wide range of applications in areas such as the environment, industries, and sensors. The biocatalysts governing the reactions could be cell secretion, cell component, or a whole cell. The electroactive bacteria can interact with insoluble materials such as electrodes for exchanging electrons through colonization and biofilm formation. Though biofilm formation is one of the major modes for extracellular electron transfer with the electrode, there are other few mechanisms through which the process can occur. Apart from biofilm formation electron exchange can take place through flavins, cytochromes, cell surface appendages, and other metabolites. The present article targets the various mechanisms of electron exchange for microbiome-induced electron transfer activity, proteins, and secretory molecules involved in the electron transfer. This review also focuses on various proteomics and genetics strategies implemented and developed to enhance the exo-electron transfer process in electroactive bacteria. Recent progress and reports on synthetic biology and genetic engineering in exploring the direct and indirect electron transfer phenomenon have also been emphasized.

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Bacteriocin: A new strategic antibiofilm agent in food industries

Cited by 27 publications

References 121 publications

Phytocompound Mediated Blockage of Quorum Sensing Cascade in ESKAPE Pathogens

Phytocompound Mediated Blockage of Quorum Sensing Cascade in ESKAPE Pathogens

Bacteriocin: A natural approach for food safety and food security

Microbiomics for enhancing electron transfer in an electrochemical system

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