Health care associated infections (HCAI) prolong hospital stay, increase mortality and costs. The objectives of the study were: to determine the characteristics of the patients, incidence rate and the microorganisms isolated in the HCAI associated to devices. A descriptive, retrospective study of patients admitted from January to December 2015 to the Adult Intensive Care Unit (ICU) with a central venous catheter (CVC); invasive mechanical ventilation (MV), and permanent urinary catheter (CUP).Data were extracted from the risk factor sheet and the HCAI notification sheet used for surveillance. 529 patients were included with exposure to invasive devices. The rate of ventilator-associated pneumonia (VAN) was 15.9 / 1000 days of MV, the rate of central venous catheter-associated bloodstream (STI / CVC) infection was 9.2 / 1000 days CVC And the urinary tract infection rate associated with permanent urinary catheter (UTI / CUP) was 4.5/1000 days CUP. The most frequent microorganisms were: NAVM, A. baumannii complex 10/31 (32%), P. aeruginosa 8/31 (26%), K pneumoniae 5/31 (16%). In ITS / CVC S. aureus 7/28 (25%), K. pneumoniae 5/28 (18%), E. faecalis 5/28 (18%), and in ITU/CUP predominance of Candida sp. 4/13 31%), Candida tropicalis, 3/13 (23%), A. baumannii 2/13 (15%). 80% of Enterococcus spp were resistant to Vancomycin, 42% of Staphylococcus spp were methicillin resistant, 70% of Acinetobacter spp, 33% of P. aeruginosa and were multiresistant. Carbapenemase produced 33% of K. pneumoniae. High resistance has been observed for which the implementation of preventive measures is fundamental.