Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation

Wilde, Craig G.; Seilhamer, Jeffrey J.; McGrogan, Michael; Ashton, Nina M.; Snable, J L; Lane, John; Leong, Steven R.; Thornton, Michael B.; Miller, Kathleen L.; Scott, Randy W.

doi:10.1016/s0021-9258(17)32454-7

Cited by 68 publications

(4 citation statements)

References 16 publications

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“…LBP has an important role in the innate immune response, which binds to the lipid A moiety of LPS and promotes the release of cytokines. 26,27 In accordance with our result, Garci ́a et al found that the diagnostic efficacy of LBP for sepsis was similar to that of CRP but lower than that of PCT in a study of 102 patients with suspected infections in the emergency department. 28 Another study in rats revealed that blocking LBP by administration of a specific blockade peptide LBPK95A could significantly inhibit neutrophils infiltration.…”

Section: ■ Discussionsupporting

confidence: 92%

Proteomic Signature of Urosepsis: From Discovery in a Rabbit Model to Validation in Humans

Zheng

Sun

et al. 2021

J. Proteome Res.

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Urosepsis after upper urinary tract endoscopic lithotripsy (UUTEL) may cause uroseptic shock with high mortality, which can be prevented if early diagnosis and timely intervention are implemented with help of a diagnostic protein panel. The plasma of five rabbits of uroseptic shock and five controls was subjected to exploratory proteomics to search biomarker candidates from proteomic profiles related to uroseptic shock. Then, plasma from 21 nonsepsis and 20 urosepsis patients according to European diagnostic criteria of sepsis was enrolled in the validation study via targeted proteomics. Changes in a massive number of plasma proteins, mainly enriched in immune regulation, coagulation, structural repair, and transport activity, were observed in the rabbit model of septic shock. Fifteen proteins were identified as differential expression proteins between sepsis and nonsepsis patients. A diagnostic model composed of three proteins lipopolysaccharide-binding protein (LBP), clusterin (CLU), and vascular cell adhesion protein 1 (VCAM1) was developed for the early detection (2 hours postoperatively) of urosepsis after UUTEL, with a high area under the receiver operating characteristic (ROC) curve of 0.921. In conclusion, changes in the proteomic profile may reflect the underlying biological mechanisms during the development of urosepsis and produce diagnostic biomarkers for the early detection of urosepsis after UUTEL.

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Section: ■ Discussionsupporting

confidence: 92%

Proteomic Signature of Urosepsis: From Discovery in a Rabbit Model to Validation in Humans

Zheng

Sun

et al. 2021

J. Proteome Res.

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“…In vertebrates, the bactericidal/permeability-increasing proteins (BPI) hold a similar function against Gram-negative bacteria, by binding lipopolysaccharide upon release by lysosomal granules of neutrophil cells (Wilde et al, 1994). BPIs are highly conserved in most metazoans, but they are crucially missing in some protostomes, including arthropods and flatworms (Baron et al, 2016).…”

Section: The Sting Pathwaymentioning

confidence: 99%

Genetic and molecular basis of the immune system in the brachiopod Lingula anatina

Gerdol

Luo

Satoh

et al. 2018

Developmental & Comparative Immunology

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“…Another factor that can influence immune cell migration is their exposure to microbial agents, such as lipopolysaccharide (LPS), which induce their activation. 21 To determine whether pre-treatment of the cells with LPS or CST can influence the blocking effect of CST, we prestimulated human monocytes 30 minutes with LPS or CST before performing the in vitro transwell migration assays (Supplementary Fig. S7).…”

Section: Resultsmentioning

confidence: 99%

The anti-inflammatory peptide Catestatin blocks chemotaxis

Muntjewerff

Parv

Mahata

et al. 2021

Journal of Leukocyte Biology

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Increased levels of the anti-inflammatory peptide Catestatin (CST), a cleavage product of the pro-hormone chromogranin A, correlate with less severe outcomes in hypertension, colitis, and diabetes. However, it is unknown how CST reduces the infiltration of monocytes and macrophages (Mϕs) in inflamed tissues. Here, it is reported that CST blocks leukocyte migration toward inflammatory chemokines. By in vitro and in vivo migration assays, it is shown that although CST itself is chemotactic, it blocks migration of monocytes and neutrophils to inflammatory attracting factor CC-chemokine ligand 2 (CCL2) and C-X-C motif chemokine ligand 2 (CXCL2). Moreover, it directs CX 3 CR1 + Mϕs away from pancreatic islets. These findings suggest that the anti-inflammatory actions of CST are partly caused by its regulation of chemotaxis.

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Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation

Cited by 68 publications

References 16 publications

Proteomic Signature of Urosepsis: From Discovery in a Rabbit Model to Validation in Humans

Proteomic Signature of Urosepsis: From Discovery in a Rabbit Model to Validation in Humans

Genetic and molecular basis of the immune system in the brachiopod Lingula anatina

The anti-inflammatory peptide Catestatin blocks chemotaxis

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