Bactericidal and Cytotoxic Activities of Polyphenol Extracts fromSolanum tuberosumspp.tuberosumand spp.andigenaCultivars onEscherichia coliand Human Neuroblastoma SH-SY5Y CellsIn Vitro

Abstract

Potatoes (Solanum tuberosum L.) are a good source of dietary antioxidant polyphenols. This study investigated the potential antioxidant, bactericidal, and cytotoxic activities in vitro of the phenolic compounds present in tubers of one S. tuberosum spp. tuberosum (Summerside), and three S. tuberosum spp. andigena (landraces Moradita, Waicha, and Santa María) cultivars. Both the content of phenolic acids, chlorogenic acids (CGAs) being the most abundant, and the antioxidant activity were higher in extracts from skin than from flesh. Extracts from Moradita flesh and Summerside skin showed bactericidal activity against Escherichia coli ATCC 25922 but failed to inhibit pathogenic E. coli O157. Both extracts lack pigmentation but do contain 5-CGA, caffeic, and ferulic acids. Positive control with gentamicin and commercial 5-CGA resulted in a complete inhibition of bacterial growth. In addition, all potato extracts and commercial 5-CGA diminished dose-dependently human neuroblastoma SH-SY5Y cell viability. Skin extracts were more potent than flesh extracts. Among flesh extracts, Moradita was the most potent. Together, our results suggest that Moradita flesh could provide a desirable source of important health-promoting substances. Findings indicate that the biological activity of potato extracts is a combination of various bioactive compounds and contribute to the revalorization of potato as a functional food.

Managing Rhizoctonia Damping-Off of Rocket (Eruca sativa) Seedlings by Drench Application of Bioactive Potato Leaf Phytochemical Extracts

“…Furthermore, these evidences support the suitability of these feedstock to be valorized as new products in a circular economy viewpoint. S. tuberosum peelings have previously investigated as potential source of new crude glycoalkaloid [ 58 ], polyphenolic [ 59 ], and polyphenolic/anthocyanin [ 60 ] antimicrobials. In addition, these natural compounds are characterized by a low persistence in the environment (the half-live of α-solanine has been estimated to vary in the range 1.8–4.1 days at 15 °C), features that makes them suitable for the field application in a perspective of ecofriendly control of plant disease.…”

Metabolite profiling and cytotoxic activity of Andean potatoes: polyamines and glycoalkaloids as potential anticancer agents in human neuroblastoma cellsin vitro

“…Moradita, Waicha, and Santa María potato cultivars were selected based on previous work from our laboratory (Silveyra et al, 2018) and other groups (Calliope et al, 2018). The skin and flesh colors are purple and yellow for Moradita, pink and yellow for Waicha, and intensely red for Santa María.…”

“…Previously, we studied the cytotoxic effect of Andean potato polyphenol extracts against human neuroblastoma and hepatocarcinoma cell lines. Treatments resulted in a dose-dependent viability reduction in all cell types (Martínez et al, 2018; Silveyra et al, 2018). However, we do not know which compound(s) exert(s) these biological activities.…”

Pigmented Potatoes: A Potential Panacea for Food and Nutrition Security and Health?

“…The study of [ 20 ] also revealed that the extracts of some pigmented potatoes were lethal against the hepatocarcinoma (Hep3B) cell lines. Silveyra et al [ 65 ] also showed that the skin and flesh extracts of some cultivars possessed some antibacterial properties against E. coli . These authors reported that the skin possessed more activities than the flesh extracts.…”