Bactericidal activity of daptomycin, vancomycin, teicoplanin and linezolid against Staphylococcus aureus, Enterococcus faecalis and Enterococcus faecium using human peak free serum drug concentrations

Safety of High‐Dose Intravenous Daptomycin Treatment: Three‐Year Cumulative Experience in a Clinical Program

“…It demonstrates concentration-dependent killing, in vitro synergy with a number of other antibiotics, and in vitro penetration into biofilm [2,[17][18][19][20][21]. Our dose selection and use of daptomycin was based on these properties, available safety data, and evidence of serious or poorly controlled infection.…”

“…Daptomycin is a novel lipopeptide antibiotic with a unique mechanism of action against gram-positive bacteria that provides potent in vitro bactericidal activity [1][2][3]. It is approved at a dose of 4 mg/kg for the treatment of complicated skin and soft-tissue infection (SSTI) and at a dose of 6 mg/kg for Staphylococcus aureus bloodstream infection (BSI), including treatrequired.…”

Activity of Telavancin against Staphylococcus aureus Isolates, Including Those with Decreased Susceptibility to Ceftaroline, from Cystic Fibrosis Patients

“…The assay was performed in Muller-Hinton broth supplemented with 0.002% polysorbate 80 for TLV and calcium at 50 μg/ml for DAP, and activity against a representative number of CF patient-derived strains, including a strain with CPT hr (TMH 5007), was tested (16–18). TLV showed activity against all the tested strains, including CPT hr strain TMH 5007, in concordance with the TLV MIC values.…”

“…Time-kill analyses were performed on 4 representative CF patient-derived strains following CLSI guidelines using human free drug maximal concentrations for TLV (8 mg/liter for a 750-mg dose), VAN (16 mg/liter for a 1,000-mg dose), LZD (10.4 mg/liter for a 600-mg dose), and CPT (16 mg/liter for a 600-mg dose) in 24-well microplates (16–18, 25). The numbers of CFU were counted by plating a sample on tryptic soy agar (TSA) at 0, 2, 4, 6, 8, and 24 h. Results were expressed as the number of CFU per milliliter versus time.…”

Intravitreal Daptomycin

“…Also, the rate of bactericidal activity against Streptococcus pneumoniae is alarmingly slow. 27–29 In these latter instances, vancomycin might halt bacterial growth but require an intraocular immune response to ultimately eliminate the infection. While there may be a destructive aspect to the infiltration of immune cells, these same cells may play an important role in clearing the eye of the harmful organism.…”