Bactericidal activity of anacardic acids against Streptococcus mutans and their potentiation

Abstract

Anacardic acids isolated from the cashew Anacardium occidentale L. (Anacardiaceae) apple and a series of their synthetic analogs, 6-alkylsalicylic acids, were found to be bactericidal against Streptococcus mutans by the time-kill curve method. The maximum antibacterial activity of 6-alkylsalicylic acids against this cariogenic bacterium showed when the carbon length comprised 12 carbon atoms in the side chain. To enhance the bactericidal activity of anacardic acids, various combinations were tested. Synergistic bactericidal activity was found in the combination of anacardic acid [6-[8(Z),ll(Z),14pentadecatrienyl]salicylic acid] and anethole or linalool.

Anacardic acid derivatives from Brazilian propolis and their antibacterial activity

“…The biological activities of the anacardic acid derivatives have attracted considerable attention for acting as molluscicides [26], anti-tumour agents [27][28], antimicrobes [29][30][31][32], antioxidants [33] and xanthine oxidase inhibitiors [34].…”

Biological activity of phenolic lipids

“…An anacardic acid mixture isolated from Amphipterygium adstringens exhibited a potent dosedependent antibacterial activity against H. pylori with a value in the inhibitory range of reference antibiotics used to test antimicrobial susceptibility and the eradication of H. pylori [137]. Anacardic acids isolated from the cashew apple also exhibited antibacterial activity against Streptococcus mutans [138,139]. Embelin, a benzoquinonederivative isolated from an Argentinean collection of Oxalis erythrorhiza, presented an inhibitory effect on methicillin-resistant Staphylococcus aureus and Escherichia coli [140].…”

Phenolic lipid ingredients from cashew nuts

“…As major components of cashew nuts, anacardic acid and its analogues have attracted considerable attention in the areas of biological activities, for example against tooth abscesses due to their lethality to Gram-positive bacteria, molluscicidal activity [2], anti-tumor activity [3][4][5], antimicrobial activity [6][7][8], inhibition of a-glucosidase, invertase and aldose reductase [9], inhibition of tyrosinase [10], antioxidant activity [11,12], antimutagenic activity [13] and inhibition of acetylcholinesterase [14]. Despite being a multifunctional and high nutritional food resource, we are more interested in its immunological modulation and effects on drug metabolism through the cytochrome P450 enzyme system.…”