Bactericidal Activity Identified in 2S Albumin from Sesame Seeds and In silico Studies of Structure–Function Relations

Maria-Neto, Simone; Honorato, Rodrigo Vargas; Costa, Fábio T.; Almeida, Renato G.; Amaro, D. S.; Oliveira, José T.A.; Vasconcelos, Ilka M.; Franco, Octávio L.

doi:10.1007/s10930-011-9337-x

Cited by 24 publications

(25 citation statements)

References 79 publications

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“…Predominant growth reduction was observed in fungi Tricoderma viride and Candida albicans. The results indicate that the extract show potential as a source of new antimicrobial drug and may impart health benefits by its antioxidant property 31 .…”

Section: In Silico Antimicrobial Activity 21 Annona Reticulatementioning

confidence: 92%

Natural Compounds as Anti Microbial Agents with In Silico Technique: A Review

Paarakh¹,

Vd²

2016

Int J Pharma Res Health Sci

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Section: In Silico Antimicrobial Activity 21 Annona Reticulatementioning

confidence: 92%

Natural Compounds as Anti Microbial Agents with In Silico Technique: A Review

Paarakh¹,

Vd²

2016

Int J Pharma Res Health Sci

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“…Several 2S albumins have been reported to possess bactericidal activity. A member of the 2S albumin family from sesame seeds ( Sesamum indicum ) specifically inhibited Klebsiella species . A 2S albumin from castor beans ( Ricinus communis ) was reported to have high in vitro antibacterial activity against human pathogenic bacteria .…”

Section: Functional Biology Of Proteins Present In Seeds and Peanutsmentioning

confidence: 99%

The functional biology of peanut allergens and possible links to their allergenicity

Ozias‐Akins

Breiteneder

2019

Allergy

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Peanut is one of the most common food triggers of fatal anaphylaxis worldwide although peanut allergy affects only 1%‐2% of the general population. Peanuts are the source of highly potent allergenic proteins. It is emerging that the allergenicity of certain proteins is linked to their biological function. Peanut is an unusual crop in that it flowers aboveground but produces its seed‐containing pods underground. This so‐called geocarpic fruiting habit exposes pods and seeds during their development to soilborne pathogens and pests. Pest damage can also open routes of entry for opportunistic fungi such as Aspergillus . Although seed proteins have primary functions in nutrient reservoirs, lipid storage bodies, or the cytoskeleton, they have also evolved to act as part of the plant's defense system to enhance fitness and survival of the species. When interacting with pathogens or pests, these proteins modify and damage cells' membranes, interact with immune receptors, and modulate signaling pathways. Moreover, following exposure, the immune system of predisposed individuals reacts to these proteins with the production of specific IgE. This review explores the evolutionary biology of peanut and its seed proteins and highlights possible links between the proteins' biological function and their allergenicity.

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“…There is then the loss of a linker peptide and short peptides from both the N- and C-terminal, leading to the generation of two subunits of 8–14 and of 3–10 kDa (Ericson et al, 1986). These peptides have low molecular masses, presenting around 4–9 kDa (Hsiao et al, 2006; Maria-Neto et al, 2011), rich in glutamine and cationic residues (Youle and Huang, 1981; de Sousa Cândido et al, 2011) and well-known for their antimicrobial and antifungal activities (Ribeiro et al, 2011). …”

Section: Fruit Antimicrobial Peptidesmentioning

confidence: 99%

“…Tn AFP1, a peptide with molecular mass of 1230 Da and isolated from fruits of Trapa natans , showed the inhibition of C. tropicalis growth in vitro and inhibited the biofilm formation in a concentration dependent manner (Mandal et al, 2011). …”

Section: Fruit Antimicrobial Peptidesmentioning

confidence: 99%

“…Moreover, the peptide Ca Thi associated with fluconazole showed inhibitory activities toward C. albicans, C. tropicalis, C. parapsilosis, C. pelliculosa, C. buinensis , and C. mogii (Taveira et al, 2016). Furthermore, it has been shown that plant AMPs cause an inhibitory effect on biofilm formation (Mandal et al, 2011), revealing that fruits could be excellent sources of bioactive molecules with promising health benefits (Skinner and Hunter, 2013). …”

Section: Biotechnological Potentialmentioning

confidence: 99%

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Antimicrobial Peptides from Fruits and Their Potential Use as Biotechnological Tools—A Review and Outlook

et al. 2017

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Bacterial resistance is a major threat to plant crops, animals and human health, and over the years this situation has increasingly spread worldwide. Due to their many bioactive compounds, plants are promising sources of antimicrobial compounds that can potentially be used in the treatment of infections caused by microorganisms. As well as stem, flowers and leaves, fruits have an efficient defense mechanism against pests and pathogens, besides presenting nutritional and functional properties due to their multifunctional molecules. Among such compounds, the antimicrobial peptides (AMPs) feature different antimicrobials that are capable of disrupting the microbial membrane and of acting in binding to intra-cytoplasmic targets of microorganisms. They are therefore capable of controlling or halting the growth of microorganisms. In summary, this review describes the major classes of AMPs found in fruits, their possible use as biotechnological tools and prospects for the pharmaceutical industry and agribusiness.

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Bactericidal Activity Identified in 2S Albumin from Sesame Seeds and In silico Studies of Structure–Function Relations

Cited by 24 publications

References 79 publications

Natural Compounds as Anti Microbial Agents with In Silico Technique: A Review

Natural Compounds as Anti Microbial Agents with In Silico Technique: A Review

The functional biology of peanut allergens and possible links to their allergenicity

Antimicrobial Peptides from Fruits and Their Potential Use as Biotechnological Tools—A Review and Outlook

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