Bactericidal Activities of Milk Lipids

Sprong, R. Corinne; Hulstein, Marco F. E.; Meer, Roelof van der

doi:10.1128/aac.45.4.1298-1301.2001

Cited by 203 publications

(153 citation statements)

References 25 publications

Supporting

Mentioning

148

Contrasting

Order By: Relevance

“…The results suggested that the activity of the castor oil could be due to the mixture of fatty acids. Fatty acids, as well as their corresponding salts, have been reported to display the antimicrobial activity (Nieman 1995;Sprong et al 2001;Skrivanova et al 2005). Despite the lack of elements which would make the inhibitory mechanism fully understood, it has been assumed that the fatty acids penetrate the lipid membrane and dissociate in the more alkaline interior causing the metabolic uncoupling (Russell and Diaz-Gonzalez 1998).…”

Section: Resultsmentioning

confidence: 99%

Control of papaya fruits anthracnose by essential oil of Ricinus communis

Júnior

Freire²,

Moreira

et al. 2012

Braz. arch. biol. technol.

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Control of papaya fruits anthracnose by essential oil of Ricinus communis

Júnior

Freire²,

Moreira

et al. 2012

Braz. arch. biol. technol.

View full text Add to dashboard Cite

“…Gut dysbiosis has been linked with endotoxin-mediated chronic disease in mouse models [51,52]. Sphingosine, a hydrolytic product of dietary SM, is known to have bactericidal effects [53]. We have previously reported that supplementation of 0.25% (w/w) milk SM to HFD-fed mice altered the fecal microbiota composition by reducing Gram-negative bacterial phyla and increasing Bifidobacterium [28].…”

Section: Discussionmentioning

confidence: 99%

Dietary Milk Sphingomyelin Reduces Systemic Inflammation in Diet-Induced Obese Mice and Inhibits LPS Activity in Macrophages

et al. 2017

View full text Add to dashboard Cite

High-fat diets (HFD) increase lipopolysaccharide (LPS) activity in the blood and may contribute to systemic inflammation with obesity. We hypothesized that dietary milk sphingomyelin (SM), which reduces lipid absorption and colitis in mice, would reduce inflammation and be mediated through effects on gut health and LPS activity. C57BL/6J mice were fed high-fat, high-cholesterol diets (HFD, n = 14) or the same diets with milk SM (HFD-MSM, 0.1% by weight, n = 14) for 10 weeks. HFD-MSM significantly reduced serum inflammatory markers and tended to lower serum LPS (p = 0.08) compared to HFD. Gene expression related to gut barrier function and macrophage inflammation were largely unchanged in colon and mesenteric adipose tissues. Cecal gut microbiota composition showed greater abundance of Acetatifactor genus in mice fed milk SM, but minimal changes in other taxa. Milk SM significantly attenuated the effect of LPS on pro-inflammatory gene expression in RAW264.7 macrophages. Milk SM lost its effects when hydrolysis was blocked, while long-chain ceramides and sphingosine, but not dihydroceramides, were anti-inflammatory. Our data suggest that dietary milk SM may be effective in reducing systemic inflammation through inhibition of LPS activity and that hydrolytic products of milk SM are important for these effects.

show abstract

“…chain length, and on the microbial strain involved. Generally, Gram-positive bacteria are more sensitive whereas Gram-negative bacteria are not (Sprong et al 2001). This phenomenon may be caused by the difference between the outer membrane of the cell wall of Gram-positive and Gram-negative bacteria (Sun et al 2003).…”

mentioning

confidence: 99%

Antimicrobial effects of fatty acid fructose esters

Karlová¹,

Poláková²,

Šmidrkal³

et al. 2010

Czech J. Food Sci.

View full text Add to dashboard Cite

Karlová T., Poláková L., Šmidrkal J., Filip V. (2010): Antimicrobial effects of fatty acid fructose esters. Czech J. Food Sci., 28: 146-149.Antimicrobial effects of various fatty acids and their esters have been extensively studied. Esters with saccharides (glucose, sucrose) have been found to have a broad spectrum of microbicidal activity. The objective of this study was to investigate the susceptibility of four microbial strains (Bacillus cereus, Escherichia coli, Saccharomyces cerevisiae, and Fusarium culmorum) to the antimicrobial properties of fatty acid (capric, lauric, myristic, and palmitic) fructose esters. Microorganisms were cultivated in liquid media supplemented with various concentrations of the tested agents. A spectrophotometric method was used for the quantitative detection of the microbial growth. Both the cultivation and measuring of the absorbance was carried out in microtiter plates. Our results indicate that the addition of the tested compounds strongly reduce the number of viable microorganisms. Higher concentrations caused microbicidal effect. The inhibitory action decreased rapidly as the chain length increased. Caprinoylfructose proved to be the most active.

show abstract

Bactericidal Activities of Milk Lipids

Cited by 203 publications

References 25 publications

Control of papaya fruits anthracnose by essential oil of Ricinus communis

Control of papaya fruits anthracnose by essential oil of Ricinus communis

Dietary Milk Sphingomyelin Reduces Systemic Inflammation in Diet-Induced Obese Mice and Inhibits LPS Activity in Macrophages

Antimicrobial effects of fatty acid fructose esters

Contact Info

Product

Resources

About