Bactericidal action of the plasma of high-frequency capacitive and barrier discharges on microorganisms

Ажаронок, В. В.; Krat'ko, L. E.; Nekrashevich, Ya. I.; Филатова, И. И.; Mel'nikova, L. A.; Дудчик, Н. В.; Yanetskaya, S. A.; Болога, М. К.

doi:10.1007/s10891-009-0210-0

Cited by 16 publications

(9 citation statements)

References 9 publications

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“…Most of the reported studies on plasma‐bio interaction are geared toward bacteria, while only a limited literature is available describing the inactivation of viruses and the mechanisms leading to virus inactivation . Ozone produced by commercially available ozonizers is found to be effective against viruses in hospital wards and operation theaters .…”

Section: Introductionmentioning

confidence: 99%

Reactive species responsible for the inactivation of feline calicivirus by a two‐dimensional array of integrated coaxial microhollow dielectric barrier discharges in air

Nayak¹,

Aboubakr

Goyal

et al. 2017

Plasma Processes & Polymers

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The use of low‐temperature plasmas for bio‐decontamination and sterilization has been gaining increased attention. In this study, a two‐dimensional array of integrated coaxial microhollow micro‐discharges generated in dry air at atmospheric pressure is used to treat metal surfaces (gas‐phase) and solution (liquid‐phase) contaminated with a known concentration of feline calicivirus (FCV). FCV acts as a surrogate for human norovirus, which is responsible for causing outbreaks of acute gastroenteritis in humans. The decontamination efficacy as well as the primary chemical pathways leading to virus inactivation in both the treatments are studied and compared. It is found that the humidity of the bio‐sample for gas‐phase treatment in dry air is required to achieve >5 log10 reduction in FCV titer within 3 min. The gas‐phase FCV inactivation is found to be due to a combination of ozone (O3) and reactive nitrogen species (RNS), most likely NOx. The liquid‐phase FCV inactivation mechanism is pH‐dependent and is primarily due to RNS, most likely acidified nitrites. O3 has a negligible effect on FCV suspended in solution. Previous studies performed in a batch reactor have shown that the inactivation pathways through O3 and RNS are mutually exclusive due to ozone poisoning at high NxOy concentrations. The present study employs a flow‐through system which avoids accumulation of reactive species and allows for the coexistence of NOx and O3 for the gas residence times used in this study, giving rise to these specific inactivation pathways.

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Section: Introductionmentioning

confidence: 99%

Reactive species responsible for the inactivation of feline calicivirus by a two‐dimensional array of integrated coaxial microhollow dielectric barrier discharges in air

Nayak¹,

Aboubakr

Goyal

et al. 2017

Plasma Processes & Polymers

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“…The use of CGP appears to be especially advantageous for decontaminating the surfaces of fresh foods, such as vegetables, fruits, meats, nuts, poultry, and eggs, and also for disinfection of food preparation surfaces (16)(17)(18)(19).…”

mentioning

confidence: 99%

“…(16), Staphylococcus aureus (18), and others (6)-are available. However, the antiviral activity of CGP has not been properly explored.…”

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confidence: 99%

Virucidal Effect of Cold Atmospheric Gaseous Plasma on Feline Calicivirus, a Surrogate for Human Norovirus

Aboubakr

Williams

Gangal

et al. 2015

Appl Environ Microbiol

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Minimal food-processing methods are not effective against foodborne viruses, such as human norovirus (NV). It is important, therefore, to explore novel nonthermal technologies for decontamination of foods eaten fresh, minimally processed and ready-to-eat foods, and food contact surfaces. We studied the in vitro virucidal activity of cold atmospheric gaseous plasma (CGP) against feline calicivirus (FCV), a surrogate of NV. Factors affecting the virucidal activity of CGP (a socalled radio frequency atmospheric pressure plasma jet) were the plasma generation power, the exposure time and distance, the plasma feed gas mixture, and the virus suspension medium. Exposure to 2.5-W argon (Ar) plasma caused a 5.55 log 10 unit reduction in the FCV titer within 120 s. The reduction in the virus titer increased with increasing exposure time and decreasing exposure distance. Of the four plasma gas mixtures studied (Ar, Ar plus 1% O 2 , Ar plus 1% dry air, and Ar plus 0.27% water), Ar plus 1% O 2 plasma treatment had the highest virucidal effect: more than 6.0 log 10 units of the virus after 15 s of exposure. The lowest virus reduction was observed with Ar plus 0.27% water plasma treatment (5 log 10 unit reduction after 120 s). The highest reduction in titer was observed when the virus was suspended in distilled water. Changes in temperature and pH and formation of H 2 O 2 were not responsible for the virucidal effect of plasma. The oxidation of viral capsid proteins by plasma-produced reactive oxygen and nitrogen species in the solution was thought to be responsible for the virucidal effect. In conclusion, CGP exhibits virucidal activity in vitro and has the potential to combat viral contamination in foods and on food preparation surfaces. Foodborne illnesses continue to plague public health, as well as world economies, costing approximately $152 billion in the United States alone (1). Enteric viruses, particularly human norovirus (NV) and hepatitis A virus (HAV), are the leading causes of viral foodborne illnesses (2). Human NV, one of the top five pathogens with respect to the total cost of foodborne illnesses in the United States, belongs to the family Caliciviridae and is a wellknown cause of "winter vomiting disease" or "stomach flu" (3). NV causes 19 to 21 million cases of acute gastroenteritis annually in the United States and leads to 1.7 to 1.9 million outpatient visits, 400,000 emergency room visits, 56,000 to 71,000 hospitalizations, and 570 to 800 deaths, mostly among young children (4). More than half of all foodborne disease outbreaks due to a known cause reported to the CDC from 2006 to 2010 were attributed to NV. In the European Union in 2007, caliciviruses (primarily NV) were responsible for 507 of 675 foodborne viral disease outbreaks (5).Multiple issues related to the quality of thermally processed foods, e.g., nutritional losses and adverse effects on organoleptic quality, have led to the emergence of so-called nonthermal technologies, which consist of preservation treatments that are effective at ambient o...

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“…The investigations were fulfilled with the use of an experimental facility described in detail in [21]. A fragment of the facility for studies of the effects of HF EMF (frequency f = 5.28 MHz) on materials is shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

Changes in the physical and mechanical properties of friction composites with a polymer matrix induced by an amplitude-modulated high-frequency electromagnetic field

Ажаронок

Anisovich

Биран

et al. 2014

Surf. Engin. Appl.Electrochem.

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This paper presents the results of experimental studies of the influence of a high frequency elec tromagnetic field on the physical, mechanical, and tribological properties of polymer friction composites for automotive brakes. It was shown that, in some cases, the treatment with an electromagnetic field results in the transformation of the polymer supramolecular structure. In the case of treatment of initial powder composi tions, significant changes (up to 20%) in the dynamic modulus of elasticity and the tribological properties of the final materials were found. The possible mechanisms of the effect of pulsed high frequency electromag netic treatment on the physical and mechanical properties of friction materials, as well as the correlation of the properties with the acoustic noise of friction units, are under discussion.

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Bactericidal action of the plasma of high-frequency capacitive and barrier discharges on microorganisms

Cited by 16 publications

References 9 publications

Reactive species responsible for the inactivation of feline calicivirus by a two‐dimensional array of integrated coaxial microhollow dielectric barrier discharges in air

Reactive species responsible for the inactivation of feline calicivirus by a two‐dimensional array of integrated coaxial microhollow dielectric barrier discharges in air

Virucidal Effect of Cold Atmospheric Gaseous Plasma on Feline Calicivirus, a Surrogate for Human Norovirus

Changes in the physical and mechanical properties of friction composites with a polymer matrix induced by an amplitude-modulated high-frequency electromagnetic field

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