Bacterially activated B-cells drive T cell differentiation towards Tr1 through PD-1/PD-L1 expression

Said, Sawsan Sudqi; Barut, G. Tuba; Mansur, Nesteren; Korkmaz, Asli; Sayi-Yazgan, Ayca

doi:10.1016/j.molimm.2018.02.010

Cited by 13 publications

(12 citation statements)

References 53 publications

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“…Therapeutic Abs targeting PD‐1 on T cells have made great breakthroughs in clinical trials . In addition to T cells, PD‐1 was found on the surface of activated monocytes, natural killer cells, dendritic cells, and B cells . In hepatocellular carcinoma, PD‐1 hi Breg cells have been identified as a new B‐cell subset .…”

Section: Discussionmentioning

confidence: 99%

Circulating exosomes from esophageal squamous cell carcinoma mediate the generation of B10 and PD‐1^high Breg cells

et al. 2019

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As one of the most frequently diagnosed cancers, esophageal squamous cell carcinoma (ESCC) remains the leading cause of malignancy‐related death worldwide. Many studies have focused on the potential role of cancer cells in educating B cells during cancer progression. Here, we aim to explore the role of circulating exosomes from ESCC in the generation of two main regulatory B (Breg) subsets, including interleukin‐10+ Bregs (B10) and programmed cell death (PD)‐1high Bregs. Firstly, we observed an elevated percentage of B10 cells in peripheral blood of ESCC patients compared with healthy controls. Then we isolated and characterized exosomes from the peripheral blood of ESCC patients and an ESCC cell line. Exosomes from ESCC patients and the ESCC cell line suppressed the proliferation of B cells and induced the augmentation of B10 and PD‐1high Breg cells. By comparing the long non‐coding RNA and mRNA expression profiles in exosomes from ESCC patients or healthy controls, we identified a series of differentially expressed genes. Finally, we undertook gene annotation and pathway enrichment analyses on differentially expressed genes to explore the potential mechanism underlying the modulatory role of cancer exosomes in B cells. Our findings contribute to the study on B cell‐mediated ESCC immunosuppression and shed light on the possible application of exosomes in anticancer therapies.

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Section: Discussionmentioning

confidence: 99%

Circulating exosomes from esophageal squamous cell carcinoma mediate the generation of B10 and PD‐1^high Breg cells

et al. 2019

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“…We have demonstrated that the combined expression of LAG-3 and CD49b on murine memory tissue-infiltrating CD4 + T cells and on human circulating memory lymphocytes allows the identification and isolation of a population of Tr1 cells (Gagliani et al, 2013b and Table 1). Since this initial observation, several studies confirmed that CD49b and LAG-3 allow to enrich for murine (Chien et al, 2017;Clemente-Casares et al, 2016;Hooper et al, 2017;Huang et al, 2017;Mascanfroni et al, 2015;Said et al, 2018;Xu et al, 2013;Yao et al, 2015) and human Tr1 cells (Andreani et al, 2014;Bacchetta et al, 2014;Farez et al, 2015;Kim et al, 2018;Koch et al, 2015 Naive CD4 + T cells can develop into Th1, Th2, Th17, and Tr1 cells. Some Th1, Th2, memory CD4 + T and Th17 cells can acquire a Tr1 cell phenotype and function when activated through their TCRs in the presence of specific cytokines and chemokines as depicted.…”

Section: Phenotype Of Murine and Human Tr1 Cellsmentioning

confidence: 90%

The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases

et al. 2018

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“…Several groups are attempting to identify and more precisely define the B cell subtype with suppressive properties among IL10-secreting B cells. We and others have shown that murine IL-10 + B cells with suppressive properties are CD9 + B cells ( 59 – 61 ). Similarly, Matsushita defined CD9/CD80 co-expression as a novel phenotypic parameter for both Breg subtypes MZ-B10 and B1-B10 cells ( 62 ), and CD9 is involved in the enhancement and maintenance of IL-10 secretion in murine and human antigen-presenting cells ( 23 , 31 ).…”

Section: Cd9 Is Involved In the Regulation Of The Lymphoid Lineagesmentioning

confidence: 91%

CD9 Tetraspanin: A New Pathway for the Regulation of Inflammation?

et al. 2018

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CD9 belongs to the tetraspanin superfamily. Depending on the cell type and associated molecules, CD9 has a wide variety of biological activities such as cell adhesion, motility, metastasis, growth, signal transduction, differentiation, and sperm–egg fusion. This review focuses on CD9 expression by hematopoietic cells and its role in modulating cellular processes involved in the regulation of inflammation. CD9 is functionally very important in many diseases and is involved either in the regulation or in the mediation of the disease. The role of CD9 in various diseases, such as viral and bacterial infections, cancer and chronic lung allograft dysfunction, is discussed. This review focuses also on its interest as a biomarker in diseases. Indeed CD9 is primarily known as a specific exosome marker however, its expression is now recognized as an anti-inflammatory marker of monocytes and macrophages. It was also described as a marker of murine IL-10-competent Breg cells and IL-10-secreting CD9+ B cells were associated with better allograft outcome in lung transplant patients, and identified as a new predictive biomarker of long-term survival. In the field of cancer, CD9 was both identified as a favorable prognostic marker or as a predictor of metastatic potential depending on cancer types. Finally, this review discusses strategies to target CD9 as a therapeutic tool. Because CD9 can have opposite effects depending on the situation, the environment and the pathology, modulating CD9 expression or blocking its effects seem to be a new promising therapeutic strategy.

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Bacterially activated B-cells drive T cell differentiation towards Tr1 through PD-1/PD-L1 expression

Cited by 13 publications

References 53 publications

Circulating exosomes from esophageal squamous cell carcinoma mediate the generation of B10 and PD‐1^high Breg cells

Circulating exosomes from esophageal squamous cell carcinoma mediate the generation of B10 and PD‐1^high Breg cells

The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases

CD9 Tetraspanin: A New Pathway for the Regulation of Inflammation?

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Bacterially activated B-cells drive T cell differentiation towards Tr1 through PD-1/PD-L1 expression

Cited by 13 publications

References 53 publications

Circulating exosomes from esophageal squamous cell carcinoma mediate the generation of B10 and PD‐1high Breg cells

Circulating exosomes from esophageal squamous cell carcinoma mediate the generation of B10 and PD‐1high Breg cells

The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases

CD9 Tetraspanin: A New Pathway for the Regulation of Inflammation?

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Product

Resources

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Circulating exosomes from esophageal squamous cell carcinoma mediate the generation of B10 and PD‐1^high Breg cells

Circulating exosomes from esophageal squamous cell carcinoma mediate the generation of B10 and PD‐1^high Breg cells