Bacterial viruses against viruses pathogenic for man?

Międzybrodzki, Ryszard; Fortuna, Wojciech; Weber‐Dąbrowska, Beata; Górski, Andrzej

doi:10.1016/j.virusres.2005.01.009

Cited by 38 publications

(35 citation statements)

References 87 publications

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“…Our results, coupled with our earlier report [10] and other data from the literature [2], reinforce a view that phage preparations could be used in the prevention and/or treatment of viral infections. However, current knowledge about the interactions between phages and human viruses is quite fragmentary, and new studies involving other in vitro and in vivo models of infection are required to determine the actual potential of phage preparations as novel antiviral agents.…”

Section: Discussionsupporting

confidence: 90%

“…Based on the data from the literature, several potential mechanisms of antiviral effects of T4 phage could be suggested, especially a competition for cellular receptors utilized by HAdV-5 which could be blocked by certain proteins of T4 phage including the capsid KGD motif, highly immunogenic outer capsid protein, or baseplate protein [2]. We decided to include the second bacteriophage, A5/80 [22], for which a mechanism of competition for cellular HAdV-5 receptors was not observed.…”

Section: Discussionmentioning

confidence: 99%

“…However, many studies have shown that phages, apart from their well-known antibacterial activity, can also exert other important effects. For instance, there are some data in the literature to indicate that phages, as well as some components of phage virions, may exert antiviral activity [2]. …”

Section: Introductionmentioning

confidence: 99%

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Inhibitory Effects of Bacteriophage Preparations on Adenoviral Replication

et al. 2019

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Background/Aims: Bacteriophages (phages) are viruses of bacteria. Escherichia coli phage (T4) can potentially interfere with adsorption of HAdV-5 to cellular integrins by its KGD motif, while staphylococcal A5/80 phage does not possess this structure. The objective of this study was to investigate the effects of T4 and A5/80 phage preparations on type 5 human adenovirus (HAdV-5) DNA synthesis and the expression of HAdV-5 genes. Methods: Experiments were performed on the A549 cell line. HAdV-5 DNA synthesis was investigated with real-time PCR. Expression of HAdV-5 early (DBP) and late (hexon) genes was determined by quantitative real-time PCR in preincubation and coincubation experiments. Results: While both phage preparations significantly reduced the expression of HAdV-5 genes, synthesis of HAdV-5 DNA was inhibited only by T4. Conclusion: Phage preparations show promise as novel antiviral agents. However, further studies are required to investigate their antiviral effects.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Inhibitory Effects of Bacteriophage Preparations on Adenoviral Replication

et al. 2019

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“…Borecky's group has described some clinical data on the effectiveness of native bacteriophage RNA in the treatment of viral infections, a phenomenon that may be partly related to interferon production [73]. The other mechanism may be the direct competition of phages with viruses for cellular receptors for viral cell entry [74]. Recently, we have provided data to support the latter option: T4 phage was found to significantly downregulate both the adsorption and replication of human adenovirus in a dosedependent manner [63].…”

Section: Phages Versus Eukaryotic Virusesmentioning

confidence: 99%

Phages and Immunomodulation

et al. 2017

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In the past years, the microbiome and its role in the pathophysiology of diseases have gained great interest. The progress of our knowledge in this field opens completely novel prospects for treating disorders, including those which are most challenging to medicine today. Of special interest are studies on the interactions of the microbiome with the immune system. Only recently has the presence of bacteriophages in the microbiome been highlighted, and their potential role in maintaining normal immunity has gained increasing attention. We summarize the available data pointing to the potential impact of phages in maintaining immunological homeostasis.

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“…Furthermore, we showed that phage may interfere with absorption and replication of adenoviruses 55. There are also more data to suggest that phages could also be used not only in ALD, but perhaps also in some forms of viral hepatitis 7. As mentioned, phages and their nucleic acid may inhibit virus replication.…”

Section: Phages In Viral Hepatitismentioning

confidence: 99%

Therapeutic potential of phages in autoimmune liver diseases

Górski

Jończyk‐Matysiak

Łusiak-Szelachowska

et al. 2018

Clinical and Experimental Immunology

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SummaryAutoimmune liver disease (ALD) poses a difficult medical challenge, as there is a significant number of patients in whom current therapy offers questionable or no benefit, yet its side effects may be serious, including the development of malignancy. Bacterial viruses (phages) have been recognized increasingly as immunomodulators contributing to immune homeostasis and curbing inflammation. Accumulating data suggest that phages may be useful in immunotherapy of ALD. Phages have been shown to down‐regulate the expression and/or production and activity of factors associated with hepatic injury [reactive oxygen species, Toll‐like receptor (TLR)‐4 activation, nuclear factor kappa B (NF‐κB) activation, proinflammatory and procoagulant activities of platelets] and up‐regulate the expression and/or production of factors demonstrated as playing a protective role [interleukin (IL)‐10, IL‐1 receptor antagonist].

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Bacterial viruses against viruses pathogenic for man?

Cited by 38 publications

References 87 publications

Inhibitory Effects of Bacteriophage Preparations on Adenoviral Replication

Inhibitory Effects of Bacteriophage Preparations on Adenoviral Replication

Phages and Immunomodulation

Therapeutic potential of phages in autoimmune liver diseases

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