Bacterial vaginosis: Treatment with clindamycin cream versus oral metrondazole

Schmitt, C; Jd, Sobel; Meriwether, C.

doi:10.1016/0020-7292(93)90409-p

Cited by 30 publications

(30 citation statements)

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“…In some studies, symptomatic candidiasis had developed in 14-30% of women treated with metronidazole [1] . Other authors reported relapse rates of BV between 14 und 39% within 1 month after metronidazole treatment and in at least 30% within 3 months [31][32][33][34][35] . Both factors could have played a role in the high dropout rate and use of medication in this study.…”

Section: Discussionmentioning

confidence: 99%

Effect of Lyophilized Lactobacilli and 0.03 mg Estriol (Gynoflor®) on Vaginitis and Vaginosis with Disrupted Vaginal Microflora: A Multicenter, Randomized, Single-Blind, Active-Controlled Pilot Study

Donders

Bulck²,

Walle

et al. 2010

Gynecol Obstet Invest

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Objectives: To evaluate the efficacy of lyophilized lactobacilli in combination with 0.03 mg estriol when compared to metronidazole in the treatment of bacterial vaginal infections. Setting: Multicenter, randomized, single-blind, active-controlled pilot study in 3 independent gynecological practices in Belgium. Methods: Forty-six, 18- to 50-year-old premenopausal women with a disrupted vaginal flora due to a bacterial vaginal infection (bacterial vaginosis, aerobic vaginitis) were included, provided that fresh phase-contrast microscopy of the vaginal fluid showed lactobacillary flora grade 2B or 3. Patients were given a blinded box with either 12 vaginal tablets of Gynoflor® (study medication) or 6 vaginal suppositories containing 500 mg metronidazole (control medication). Eight efficacy variables were studied to assess the status of the vaginal flora at entry, 3–7 days (control 1), 4–6 (control 2) weeks and 4 months after the end of therapy. Results: At control 1, the combined variables equally improved in the lactobacilli group as in the metronidazole group. At control 2, the lactobacillus preparation showed slightly inferior results when compared to metronidazole. At 4 months, this analysis could not be performed due to low numbers, but analysis of recurrence rate and extra medication needed was not different between both groups. Conclusion: Lyophilized lactobacilli in combination with low-dose estriol are equivalent to metronidazole in the short-term treatment of bacterial vaginal infections, but have less effect after 1 month. Further studies are required to evaluate the long-term efficacy of lactobacilli when applied repeatedly.

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Section: Discussionmentioning

confidence: 99%

Effect of Lyophilized Lactobacilli and 0.03 mg Estriol (Gynoflor®) on Vaginitis and Vaginosis with Disrupted Vaginal Microflora: A Multicenter, Randomized, Single-Blind, Active-Controlled Pilot Study

Donders

Bulck²,

Walle

et al. 2010

Gynecol Obstet Invest

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“…Diagnosis is confirmed by testing vaginal secretions. Bacterial vaginosis appears to increase the risk of pelvic inflammatory diseases, postabortion and postpartum endometritis, post-hysterectomy vaginal cuff infection, chorioamnionitis, premature rupture of membranes, preterm labor, and preterm birth [5].…”

Section: Introductionmentioning

confidence: 99%

Identification of medicinal plants effective in infectious diseases in Urmia, northwest of Iran

Bahmani

Saki

Shahsavari

et al. 2015

Asian Pacific Journal of Tropical Biomedicine

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A B S T R A C TObjective: To identify the medicinal plants effective in infectious diseases. Methods: Initially, we obtained a list of herbalists and traditional healers from Food and Drug Deputy. Direct observations and interviews as well as collection of herbarium specimens of indigenous medicinal plants effective in infectious diseases of urinary tract, reproductive, digestive, respiratory and skin systems were performed. This study was conducted through questionnaires and interviews; the questionnaires were distributed among traditional healers and simultaneous interviews were also run. The plants were herbariumized, herbarium specimens were authenticated, and their species were determined by using reliable flora and other sources. Finally, the data were input into Excel 2010 and analyses were performed. Results: Out of the studied plants, 35 native medicinal plants belonging to 17 families were effective in the treatment of various diseases and infections. In this study, the Lamiaceae family had the highest frequency of plants for the treatment of infections. Traditional healers of Urmia in 24% of cases used the leaves of medicinal herb to treat patients. In 68% of cases, they prescribed medicinal herbs in the boiled forms. Most medicinal herbs showed therapeutic effect on the digestive system. Conclusions: Traditional medicinal sources, valuable knowledge of traditional healers in Urmia, the scientific investigation of the effects of the herbs offered in this study and their effects in traditional medicine may provide a good source for new drugs in modern medicine.

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“…Comparative studies of these standard therapies have revealed no differences in efficacy or safety when used in the treatment of BV 6,[10][11][12][13] . Topical regimens also offer the significant advantage of fewer unwanted systemic effects.…”

Section: Discussionmentioning

confidence: 99%

“…Currently used intravaginal therapies are clindamycin vaginal cream (2%, once daily for 3 or 7 days) and metronidazole gel (0.75%, once or twice daily for 5 days). Several studies that have compared the oral and local therapeutic regimens have found similar efficacy and safety profiles when clindamycin is used in the treatment of BV 6,[10][11][12][13] . In 1993, it was demonstrated that a 3-day course of clindamycin vaginal cream was as effective as the standard 7-day regimen 14 .…”

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confidence: 99%

Efficacy of Clindamycin Vaginal Ovule (3‐Day Treatment) vs.Clindamycin Vaginal Cream (7‐Day Treatment) in Bacterial Vaginosis

Sobel

Peipert

McGregor

et al. 2000

Infectious Diseases in Obstetrics and Gynecology

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Objective:To compare the efficacy and safety of a 3-day regimen of clindamycin vaginal ovules with a 7-day regimen of clindamycin vaginal cream for the treatment of bacterial vaginosis (BV). Methods: Women with a clinical diagnosis of BV were treated with a 3-day course of clindamycin ovules or a 7-day course of clindamycin cream administered intravaginally. Three hundred and eighty-four patients received study drug and were included in the evaluable patient population (ovule group, n = 204; cream group, n = 180). Assessments included pelvic examination and diagnostic testing. Primary efficacy endpoints were a resolution of two of three diagnostic criteria at the first follow-up visit and three of three diagnostic criteria at the second. Results: Cure rates in the evaluable patient population were similar between treatment groups: 53.7% (109/204) for the ovule group and 47.8% (85/180) for the cream group (p = 0.2471, 95% CI 4.1-16.0%). The most commonly reported medical event, vulvovaginal pruritus, had similar incidence in both treatment groups. Conclusions: A 3-day course of clindamycin vaginal ovules is as effective and well-tolerated as a 7-day course of clindamycin vaginal cream in the treatment of BV.

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Bacterial vaginosis: Treatment with clindamycin cream versus oral metrondazole

Cited by 30 publications

References 0 publications

Effect of Lyophilized Lactobacilli and 0.03 mg Estriol (Gynoflor®) on Vaginitis and Vaginosis with Disrupted Vaginal Microflora: A Multicenter, Randomized, Single-Blind, Active-Controlled Pilot Study

Effect of Lyophilized Lactobacilli and 0.03 mg Estriol (Gynoflor®) on Vaginitis and Vaginosis with Disrupted Vaginal Microflora: A Multicenter, Randomized, Single-Blind, Active-Controlled Pilot Study

Identification of medicinal plants effective in infectious diseases in Urmia, northwest of Iran

Efficacy of Clindamycin Vaginal Ovule (3‐Day Treatment) vs.Clindamycin Vaginal Cream (7‐Day Treatment) in Bacterial Vaginosis

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