Bacterial Vaginosis: Effects on reproduction and its therapeutics

Ding, Chuanfeng; Yu, Yongsheng; Zhou, Qian

doi:10.1016/j.jogoh.2021.102174

Cited by 14 publications

(5 citation statements)

References 129 publications

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“…It was also commonly identified in endometrial fluid and endometrial biopsy samples collected from women undergoing ART [25]. In BV there is usually an environmental transition from a mixture dominated by Lactobacillus to an overgrowth of facultative and strict anaerobic microbes, including Gardnerella , Prevotella , Mycoplasma and Sneathia [19, 20]. Evidence from previous studies suggests that BV is significantly more prevalent in infertile women [26–28].…”

Section: Discussionmentioning

confidence: 99%

“…In the samples from patients who did not become pregnant after IVF, several differential bacteria were identified. One of these was Gardnerella, which is a pathogenic bacterium that could cause bacterial vaginosis (BV) [18][19][20] and chronic endometritis (CE) [21,22]. In almost all cases of BV, Gardnerella was detected as a member the vaginal microbiome, although it was also detected in the non-BV samples [23,24].…”

Section: Discussionmentioning

confidence: 99%

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Characterization of the follicular fluid microbiota based on culturomics and sequencing analysis

Wei

Zhou

et al. 2023

Journal of Medical Microbiology

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Introduction. The human oocyte microenvironment is follicular fluid, which is important for follicle growth, ovulation and maturation of the oocyte. The micro-organisms present in follicular fluid could be a predictor of in vitro fertilization outcomes. Hypothesis/Gap Statement. Women with follicular fluid colonized with micro-organisms can be asymptomatic, but the presence of some genera in the follicular fluid correlates with in vitro fertilization. Aim. To confirm the existence of micro-organisms in follicular fluid, and to profile the micro-organisms present in follicular fluid sampled from women undergoing in vitro fertilization with different outcomes. Methodology. Women undergoing in vitro fertilization (n=163) were divided into different subgroups according to their in vitro fertilization outcomes. Their follicular fluid samples were collected, and among them, 157 samples were analysed by 16S rDNA sequencing, and 19 samples were analysed using culturomics. Results. The culturomics results suggested that the 19 follicular fluid samples were not sterile. The isolation rates for Streptococcus , Finegoldia and Peptoniphilus were >50 % in the 19 samples. Linear discriminant analysis effect size analysis showed differential bacteria abundance according to the pregnancy rate, the rate of normal fertilization, the rate of high-quality embryos and the rate of available oocytes. The sequencing results showed that micro-organisms could be detected in all 157 samples. Pseudomonas , Lactobacillus , Comamonas , Streptococcus and Acinetobacter were detected in all of the samples, but with a wide range of relative abundance. Pseudomonas , Lactobacillus , Ralstonia and Vibrio constituted a notable fraction of the microbiota. Conclusions. Follicular fluid is not sterile. Micro-organisms in follicular fluid could be a predictor of in vitro fertilization outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Characterization of the follicular fluid microbiota based on culturomics and sequencing analysis

Wei

Zhou

et al. 2023

Journal of Medical Microbiology

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“…Chronic low-grade inflammation is an important risk factor involved in the occurrence and development of PCOS, which may promote hyperandrogenemia and insulin resistance and participate in pathological changes observed in PCOS (Shorakae et al, 2018). It is worth noting that previous studies have reported that inflammation and infection of the lower reproductive tract may affect function further up the reproductive tract (Rampersaud et al, 2012;Haahr et al, 2016;Ding et al, 2021). Patients with PCOS may have primary ovarian inflammatory injury, which affects the development and even occurrence of PCOS through the hypothalamic-pituitary-ovary axis.…”

Section: Discussionmentioning

confidence: 99%

Changes in Vaginal Microbiome Diversity in Women With Polycystic Ovary Syndrome

Wang

Yang

et al. 2021

Front. Cell. Infect. Microbiol.

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Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects women. It can be accompanied by many clinical manifestations that can vary between individuals. Previous studies have found that there are specific changes in the intestinal flora of PCOS patients, and interventions to modify the intestinal flora can significantly improve the symptoms of PCOS. Women with PCOS have a higher incidence of vaginitis compared to healthy women. Few studies to-date have focused on investigating vaginal flora. Here, we aimed to explore distribution changes of the vaginal microbiome in PCOS patients. We recruited 42 PCOS patients (T-PCOS) and 24 healthy controls (T-control). 16s rRNA gene sequencing was used to sequence their vaginal microbiome. Normally, Lactobacillus was dominated in vaginal. Lactobacillus-dominated-type vaginal microbiome in T-PCOS and T-control (L-PCOS and L-control) and non-Lactobacillus-dominated-type vaginal microbiome in T-PCOS and T-control (N-PCOS and N-control) were analyzed separately. A total of 655 operational taxonomic units were detected in this sequencing, including 306 unique to T-PCOS, 202 unique to T-control, and 147 common between the two groups. At the genus level, Lactobacillus accounted for more than 70% of the total microbiome. Observed species (P = 0.021), Chao1 index (P = 0.020), and ACE index (P = 0.023) decreased significantly in L-PCOS. Principal component analysis showed no statistically significant differences among the subgroups. There were significant statistical differences in principal coordinate analysis in the Jaccard distance between the T-PCOS and T-control groups and between the L-PCOS and L-control groups. Linear discriminant analysis effect size found that Enterococcus and Actinomycetes were significantly different in the T-PCOS group. Atopobium and Actinomyces were statistically significantly different in patients with L-PCOS and N-PCOS group, respectively. Environmental factor analysis found that Ezakiella was significantly negatively correlated with age, while Streptococcus was significantly negatively correlated with follicle stimulating hormone. There were statistically significant differences between PCOS patients and healthy women in the vaginal microbiome, regardless of the abundance of Lactobacillus. Alpha diversity of vaginal microbiome decreased markedly in PCOS patients when it was dominated by Lactobacillus spp. Actinomyces could be a potential biomarker to identify PCOS. Streptococcus may have an impact on the pathological changes in PCOS by affecting the female reproductive endocrine environment.

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“…Bacterial vaginosis, precipitated by microbes such as Gardnerella vaginalis , Ureaplasma urealyticum , Mycoplasma hominis , and Prevotella spp., disrupts the harmonious balance of the vaginal environment. Such disturbances might attenuate sperm motility and instigate sperm mortality, culminating in fertility challenges ( Ding et al., 2021 ; Ravel et al., 2021 ).…”

Section: Post Infectious Sequalaementioning

confidence: 99%

Beyond the acute phase: a comprehensive literature review of long-term sequelae resulting from infectious diseases

Izquierdo-Condoy,

Vásconez-Gonzáles,

Morales-Lapo

et al. 2024

Front. Cell. Infect. Microbiol.

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Infectious diseases have consistently served as pivotal influences on numerous civilizations, inducing morbidity, mortality, and consequently redirecting the course of history. Their impact extends far beyond the acute phase, characterized by the majority of symptom presentations, to a multitude of adverse events and sequelae that follow viral, parasitic, fungal, or bacterial infections. In this context, myriad sequelae related to various infectious diseases have been identified, spanning short to long-term durations. Although these sequelae are known to affect thousands of individuals individually, a comprehensive evaluation of all potential long-term effects of infectious diseases has yet to be undertaken. We present a comprehensive literature review delineating the primary sequelae attributable to major infectious diseases, categorized by systems, symptoms, and duration. This compilation serves as a crucial resource, illuminating the long-term ramifications of infectious diseases for healthcare professionals worldwide. Moreover, this review highlights the substantial burden that these sequelae impose on global health and economies, a facet often overshadowed by the predominant focus on the acute phase. Patients are frequently discharged following the resolution of the acute phase, with minimal long-term follow-up to comprehend and address potential sequelae. This emphasizes the pressing need for sustained vigilance, thorough patient monitoring, strategic health management, and rigorous research to understand and mitigate the lasting economic and health impacts of infectious diseases more fully.

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Bacterial Vaginosis: Effects on reproduction and its therapeutics

Cited by 14 publications

References 129 publications

Characterization of the follicular fluid microbiota based on culturomics and sequencing analysis

Characterization of the follicular fluid microbiota based on culturomics and sequencing analysis

Changes in Vaginal Microbiome Diversity in Women With Polycystic Ovary Syndrome

Beyond the acute phase: a comprehensive literature review of long-term sequelae resulting from infectious diseases

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