Bacterial Vaginosis–Associated Bacteria in Men

Manhart, Lisa E.; Khosropour, Christine M; Liu, Congzhu; Gillespie, Catherine W.; Depner, Kevin; Fiedler, Tina L.; Marrazzo, Jeanne M.; Fredricks, David N.

doi:10.1097/olq.0000000000000054

Cited by 58 publications

(36 citation statements)

References 28 publications

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“…Other BVAB (BVAB-2, BVAB-3, Megasphera) were most often identified in cases compared to in controls but were less common. Our group has previously reported that Gardnerella vaginalis, a common species within the vaginal microbiota and implicated in BV, was more common in controls than in NGU cases and associated with recent penile-vaginal sex (26); and as reported by Manhart et al, no association with Atopobium vaginae and NGU was found (unpublished data). These data support the broader premise that exchange of pathogenic and nonpathogenic species within the genital microbiota is occurring between sexual partners, with only some agents inducing disease or symptoms in a partner, which could also be influenced by host characteristics.…”

Section: Discussionmentioning

confidence: 44%

“…The concept that the spectrum of pathogens may differ between MSM and MSW is further supported by the recent findings of Manhart et al, who examined whether key bacterial vaginosisassociated bacteria (BVAB) may be causal agents of acute NGU (26). In a case-control study involving predominantly MSW, Leptotrichia/Sneathia species were the only BVAB significantly associated with NGU and were detected in 15% of men with idiopathic NGU (26).…”

Section: Discussionmentioning

confidence: 62%

“…In a case-control study involving predominantly MSW, Leptotrichia/Sneathia species were the only BVAB significantly associated with NGU and were detected in 15% of men with idiopathic NGU (26). Other BVAB (BVAB-2, BVAB-3, Megasphera) were most often identified in cases compared to in controls but were less common.…”

Section: Discussionmentioning

confidence: 99%

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Characteristics of Acute Nongonococcal Urethritis in Men Differ by Sexual Preference

et al. 2014

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N ucleic acid amplification techniques (NAAT) have allowed greater understanding of the variety of pathogens involved in acute nongonococcal urethritis (NGU) (1). This has included the recent recognition of Mycoplasma genitalium, herpes simplex virus (HSV), and adenoviruses as urethral pathogens (2-5), although in a significant proportion of cases no urethral pathogen is currently identified. The role of Ureaplasma urealyticum in NGU has been somewhat controversial, but recent evidence implicates specific biovars and possibly higher bacterial loads as causally associated with acute NGU (6-8). Sporadic case reports implicate other bacteria such as Haemophilus species (Haemophilus influenzae and Haemophilus parainfluenzae), Streptococcus species (Streptococcus pneumoniae and Streptococcus pyogenes), and Moraxella catarrhalis in acute NGU, following orogenital sex (9-11); however, their etiologic role has not been established in case-control studies.Diagnostic and management approaches to acute NGU do not differentiate between men who have sex with men (MSM) and men who have sex with women (MSW). Yet sexual behaviors differ considerably between these groups, and it is therefore likely that the spectrum of pathogens varies. In support of this, a previous case-control study of NGU in our service found that Chlamydia trachomatis or M. genitalium were more likely to be associated with female partners, while viruses, such as HSV and adenovirus, were associated with a recent history of male sexual partners (2). Further elucidation of the etiology of this common syndrome, and developing an understanding of how sexual practices influence the detection of urethral pathogens, could improve the management of men and their partners (1,12,13). In this study, we examined behavioral, demographic, and laboratory characteristics of a large series of MSW and MSM with acute urethral symptoms over a 6-year period. We aimed to determine if there were key differences between MSW and MSM with acute NGU in the spectrum of pathogens involved and whether there were differences in sexual behavior preceding the acquisition of NGU. MATERIALS AND METHODSStudy population. We retrospectively reviewed the electronic case record database of Melbourne Sexual Health Centre, the main public sexually transmitted diseases clinic in Melbourne, Australia, from January 2006 to December 2011. Patients were required to have the diagnosis of acute NGU entered into the electronic medical record, with one or more of the following acute urethral symptoms for less than 1 month's duration: urethral discharge and urethral irritation, discomfort, or itch; patients also needed to fulfill the conventional laboratory definition of urethritis, namely, 5 or more polymorphic neutrophilic lymphocytes/high-powered field (Ն5 polymorphonuclear leukocytes [PMNL]/high-powered field [HPF]) on urethral Gram stain. Importantly, only a single first episode of acute NGU per case over the study period was included. All subsequent

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Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 62%

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Characteristics of Acute Nongonococcal Urethritis in Men Differ by Sexual Preference

et al. 2014

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“…It was recently detected in men with non-gonoccocal urethritis (NGU) along with Megasphaera spp., Leptotrichia/Sneathia spp., and Atopobium spp 17 . In that study, M. indolicus was associated with report of prior episodes of NGU and STI.…”

Section: Discussionmentioning

confidence: 97%

“…Detection of fastidious urogenital bacterial species with quantitative PCR (qPCR) has been associated with preterm birth 15 , persistent BV 16 , and urethritis in men 17 . Here we applied this methodology to investigate the relationship of eight BV-associated bacterial species/genera and three of the most common vaginal lactobacilli with cervicitis in a retrospective case control study of women attending a Seattle STD clinic.…”

Section: Introductionmentioning

confidence: 99%

Relationship of Specific Bacteria in the Cervical and Vaginal Microbiotas With Cervicitis

Gorgos

Sycuro

Srinivasan

et al. 2015

Sexually Transmitted Diseases

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Background Cervicitis is an inflammatory condition of the cervix associated with upper genital tract infection and reproductive complications. Although cervicitis can be caused by several known pathogens, the etiology frequently remains obscure. Here we investigate vaginal bacteria associated with bacterial vaginosis as potential causes of cervicitis. Methods Associations between vaginal bacteria and cervicitis were assessed in a retrospective case control study of women attending a Seattle STD clinic. Individual bacterial species were detected using two molecular methods: quantitative PCR (qPCR) and broad range 16S rRNA gene PCR with pyrosequencing. The primary finding from this initial study was evaluated using qPCR in a second cohort of Kenyan women. Results The presence of Mageeibacillus indolicus, formerly BVAB3, in the cervix was associated with cervicitis, while the presence of Lactobacillus jensenii was inversely associated. Quantities of these bacteria did not differ between cervicitis cases and controls, though in a model inclusive of presence and abundance, M. indolicus remained significantly associated with cervicitis after adjustment for other cervicitis-causing pathogens. M. indolicus was not associated with cervicitis in our study of Kenyan women, possibly due to differences in the clinical definition of cervicitis. Conclusions Colonization of the endocervix with M. indolicus may contribute to the clinical manifestations of cervicitis, but further study is needed to determine whether this finding is repeatable and applicable to diverse groups of women. Colonization of the cervix with L. jensenii could be a marker of health, perhaps reducing inflammation or inhibiting pathogenic infection.

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S neathia

Eisenberg¹,

Glaeser²,

Blom³

et al. 2018

Bergey's Manual of Systematics of Archaea and Bacteria

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Sneath'i.a. N.L. fem. n. Sneathia named after the British microbiologist Peter H. A. Sneath, in recognition of his outstanding contributions to microbial systematics. Fusobacteria / Fusobacteriia / Fusobacteriales / Leptotrichiaceae / Sneathia Gram‐stain‐negative , asporogenous, rod‐shaped bacteria ; nonmotile. Cells may display pleomorphism, and filaments may be observed. Anaerobic , although some strains may show poor growth in CO 2 . Fermentative metabolism. Acid but no gas is produced from glucose . Acid is not produced from ribose or maltose. Lactic acid, formic acid, and minor amounts of acetic acid are the end products of glucose metabolism; succinic acid may be produced. Fastidious ; requires serum or blood for growth. Optimum temperature for growth 35–37°C. Catalase and oxidase negative. Esculin and hippurate are hydrolyzed but starch is not. β‐Glucuronidase is produced. Indole is not produced. Voges–Proskauer negative. Nitrate is not reduced to nitrite. DNA G + C content (mol%) : 22–25 [derived from genomic data (dfgd)]. Type species : Sneathia sanguinegens Collins, Hoyles, Törnqvist, von Essen and Falsen 2002, 687 VP (Validation List no. 85) (Effective publication: Collins, Hoyles, Törnqvist, von Essen and Falsen 2001, 360).

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Bacterial Vaginosis–Associated Bacteria in Men

Cited by 58 publications

References 28 publications

Characteristics of Acute Nongonococcal Urethritis in Men Differ by Sexual Preference

Characteristics of Acute Nongonococcal Urethritis in Men Differ by Sexual Preference

Relationship of Specific Bacteria in the Cervical and Vaginal Microbiotas With Cervicitis

S neathia

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