Bacterial Vaginosis and Susceptibility to HIV Infection in South African Women: A Nested Case‐Control Study

Myer, Landon; Denny, Lynette; Telerant, Robin; Souza, Michelle De; Wright, Thomas; Kuhn, Louise

doi:10.1086/462427

Cited by 232 publications

(176 citation statements)

References 40 publications

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“…Bacterial [15]. It has been documented that bacterial vaginosis propagates viral replication and vaginal shedding of the HIV-1 and HSV-2 viruses, thereby further enhancing the spread of these sexually transmitted diseases [4].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Bacterial Vaginosis among Antenatal Patients at Federal Teaching Hospital Abakaliki, South East Nigeria

Asiegbu¹,

Asiegbu²,

Onwe³

et al. 2018

OJOG

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Bacterial vaginosis (BV) is the most common cause of vaginal discharge in women of child bearing age. About half of these women are asymptomatic. Adverse outcomes are consistently associated with bacterial vaginosis in pregnancy and in the puerperium. This study, which was done to look at the prevalence, involved recruiting 230 participants, and screening them for BV using the Amsel's criteria. It is hoped that identification and treatment of these women will help prevent some of the sequela associated with BV. Restoration of the vaginal microflora by treating identified cases of BV will also help reduce the transmission of HIV and herpes simplex virus (HSV) as BV propagates their replication and vaginal shedding. Two hundred and thirty women in the age range 16 -40 years were screened for BV. All the participants douched, soap and water being predominantly used. 55 women (23.9%) had BV based on Amsel's criteria. Women with only one sexual consort had the highest incidence of BV (51.9%).

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Section: Introductionmentioning

confidence: 99%

Prevalence of Bacterial Vaginosis among Antenatal Patients at Federal Teaching Hospital Abakaliki, South East Nigeria

Asiegbu¹,

Asiegbu²,

Onwe³

et al. 2018

OJOG

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“…1,2 . Several studies have demonstrated the possibility of an association between bacterial vaginosis and transmission of HIV 3 . One of the methods of diagnosis of bacterial vaginosis is by Nugent's criteria based on evaluation of normal flora in gram stained smears of vaginal discharge 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Bacterial Vaginosis in Indian Women in the Reproductive Age Group

Tiyyagura

Taranikanti

Ala

et al. 2012

Int Jour of Biomed Res

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Background: Bacterial vaginosis is a vaginal infection in women in the reproductive age group with complex change in vaginal flora. Many women are asymptomatic but some women present with abnormal vaginal discharge. It can lead to complications like preterm birth, infertility, post partum endometritis and first trimester loss. Nugent's criteria are used to diagnose bacterial vaginosis. Objectives: This study was done with the objective of analyzing the type of bacteria causing vaginosis in different age groups during the reproductive period of a woman's life. 100 women with vaginal discharge (test group) and 50 women (control group) attending the gynaecology outpatient for other problems were included in the study. Three high vaginal swabs were taken and examined for clue cells and mobiluncus spp. pH of the vaginal secretions was noted. Gram stain was done to quantify bacterial morphotypes. Diagnosis was done using the Nugent's scoring system. Results: A significantly high incidence (p<0.05) was found in the test group. 53% of women with vaginal discharge were in the age group of 21-30 years indicating that vaginosis is very common in the early reproductive years. Mobiluncus spp. was found only in the test group. 46% had an abnormal Nugent's score and 53% of test group women had all the 4 criteria to diagnose as bacterial vaginosis. Conclusion: Screening asymptomatic women and quantifying the bacteria in symptomatic patients to provide appropriate treatment would reduce the incidence and prevalence of bacterial vaginosis in the population.

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“…This has led to the use of long term, low dose suppressive therapy for BV. Other studies also suggest that the incidence of BV increases the risk of sexually transmitted infections [10], and therefore, it is essential to develop new approaches to the preservation of a healthy vagina, particularly therapies which can be readily available, economical and with a higher efficacy in terms of reducing recurrences.…”

Section: Introductionmentioning

confidence: 99%

Clinical Study of Bacillus coagulans Unique IS-2 (ATCC PTA-11748) in the Treatment of Patients with Bacterial Vaginosis

2011

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Bacterial vaginosis (BV) is the most prevalent vaginal infection worldwide and is characterized by reduction of native lactobacilli. Antimicrobial therapy used to cure the disease is often found to be ineffective. We postulate that Bacillus coagulans Unique IS-2 (Unique Biotech Limited, India) might provide an appendage to antimicrobial treatment and improve curing rate. In the present study 40 Indian women diagnosed with BV by the presence of symptoms including white discharge, pH greater than 4.7, burning micturation, itching, soreness and redness at vulva. The subjects were divided in 2 groups probiotic (n = 20) and control (n = 20) based on age (control group, 33 ± 3 years and probiotic group, 32.5 ± 3 years), history of previous vaginosis (control group, 75% or 15/20 and probiotic group, 75% or 15/20) and severity of current vaginosis infection (burning micturation and itching, 35% in each group). Probiotic group subjects were assigned to receive a dose of antibiotic therapy [Ofloxacin-Ornidazole with strength of 200-500 mg per capsule/day for 5 days along with vaginal peccaries (co-kimaxazol) for 3 days] simultaneously with two probiotic capsules (10 9 CFUs of Bacillus coagulans Unique IS-2 per capsule). The control group received only antibiotic therapy. At the end of the treatment the 80% of probiotic group subjects showed significant positive response as revealed by reduction of vaginosis symptoms compared to the control group which exhibited reduction in 45% subjects only. Thus, the results of present study indicate that strain Bacillus coagulans Unique IS-2 can provide benefits to women being treated with antibiotics to cure an infectious condition.

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Bacterial Vaginosis and Susceptibility to HIV Infection in South African Women: A Nested Case‐Control Study

Abstract: BV may account for a substantial fraction of new HIV infections in this setting. Treatment of BV and other interventions to promote normal vaginal flora warrant attention for HIV prevention.

Cited by 232 publications

References 40 publications

Prevalence of Bacterial Vaginosis among Antenatal Patients at Federal Teaching Hospital Abakaliki, South East Nigeria

Prevalence of Bacterial Vaginosis among Antenatal Patients at Federal Teaching Hospital Abakaliki, South East Nigeria

Bacterial Vaginosis in Indian Women in the Reproductive Age Group

Clinical Study of Bacillus coagulans Unique IS-2 (ATCC PTA-11748) in the Treatment of Patients with Bacterial Vaginosis

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