Bacterial vaginosis and inflammatory response showed association with severity of cervical neoplasia in HPV‐positive women

Castro-Sobrinho, Juçara Maria de; Rabelo-Santos, Sílvia Helena; Fugueiredo-Alves, Rosane Ribeiro; Derchain, Sophie; Sarian, Luís Otávio; Pitta, Denise Rocha; Campos, Elisabete Aparecida; Zeferino, Luíz Carlos

doi:10.1002/dc.23388

Cited by 34 publications

(20 citation statements)

References 47 publications

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“…In addition, patients with persistent HPV infection showed a significantly higher prevalence of BV than patients with HPV clearance ( 129 ). Another study showed an association between cervical neoplasia (CIN2+) and the presence of BV (odds ratio: 3.90), providing additional support for the association between BV, HPV infection, and cervical cancer development ( 130 ).…”

Section: The Role Of Vaginal Microbiome Analysis In Hpv Diagnosis Andmentioning

confidence: 90%

Self-Sampling for Human Papillomavirus Testing: Increased Cervical Cancer Screening Participation and Incorporation in International Screening Programs

Gupta¹,

Palmer²,

Bik³

et al. 2018

Front. Public Health

114

119

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In most industrialized countries, screening programs for cervical cancer have shifted from cytology (Pap smear or ThinPrep) alone on clinician-obtained samples to the addition of screening for human papillomavirus (HPV), its main causative agent. For HPV testing, self-sampling instead of clinician-sampling has proven to be equally accurate, in particular for assays that use nucleic acid amplification techniques. In addition, HPV testing of self-collected samples in combination with a follow-up Pap smear in case of a positive result is more effective in detecting precancerous lesions than a Pap smear alone. Self-sampling for HPV testing has already been adopted by some countries, while others have started trials to evaluate its incorporation into national cervical cancer screening programs. Self-sampling may result in more individuals willing to participate in cervical cancer screening, because it removes many of the barriers that prevent women, especially those in low socioeconomic and minority populations, from participating in regular screening programs. Several studies have shown that the majority of women who have been underscreened but who tested HPV-positive in a self-obtained sample will visit a clinic for follow-up diagnosis and management. In addition, a self-collected sample can also be used for vaginal microbiome analysis, which can provide additional information about HPV infection persistence as well as vaginal health in general.

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Section: The Role Of Vaginal Microbiome Analysis In Hpv Diagnosis Andmentioning

confidence: 90%

Self-Sampling for Human Papillomavirus Testing: Increased Cervical Cancer Screening Participation and Incorporation in International Screening Programs

Gupta¹,

Palmer²,

Bik³

et al. 2018

Front. Public Health

114

119

View full text Add to dashboard Cite

show abstract

“…Reports have suggested that human papillomavirus (HPV), such as HPV 16 and 18, are well established as an etiological agent for CC and have the ability to transform normal cervical cells into neoplastic cells [2, 3]. However, infection with HPV by itself is thought to be insufficient for the malignant transformation of HPV infected normal cervical cells [4]. Recently, with the deepening research on CC, it has been confirmed that HPV infection along with persistent chronic inflammation can induce carcinogenesis [2, 4].…”

Section: Introductionmentioning

confidence: 99%

“…However, infection with HPV by itself is thought to be insufficient for the malignant transformation of HPV infected normal cervical cells [4]. Recently, with the deepening research on CC, it has been confirmed that HPV infection along with persistent chronic inflammation can induce carcinogenesis [2, 4]. …”

Section: Introductionmentioning

confidence: 99%

CD200Fc reduces LPS-induced IL-1β activation in human cervical cancer cells by modulating TLR4-NF-κB and NLRP3 inflammasome pathway

Shao

Zhang

et al. 2017

Oncotarget

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Chronic inflammation plays an important role in tumorigenesis of cervical cancer. CD200Fc, a CD200R1 agonist, has been found to have anti-inflammatory effects in autoimmune diseases and neuro-degeneration. However, the anti-inflammatory effect of CD200Fc on cervical cancer has not yet to be completely understood. This study investigated the anti-inflammatory effects and mechanisms of CD200Fc in LPS-induced human SiHa cells and Caski cells. SiHa cells and Caski cells were stimulated with 40 μg/ml LPS under different concentrations of CD200Fc for 90 min or 12 hours. The mRNA and protein levels of pro-IL-1β, cleaved-IL-1β and NLRP3, as well as the protein level of cleaved caspase-1, were significantly increased in LPS-induced SiHa cells and Caski cells. LPS stimulation did not change ASC and pro-caspase-1 expression. CD200Fc down-regulated protein expression of cleaved caspase-1 and mRNA and protein expression of pro-IL-1β, cleaved-IL-1β and NLRP3. In addition, the protein levels of TLR4, p-P65 and p-IκB, as well as the translocation of P65 to nucleus, were significantly increased in LPS-induced SiHa cells and Caski cells. LPS stimulation did not change t-P65 and t-IκB on protein levels, which were components of TLR-NF-κB pathway. CD200Fc down-regulated protein expression of TLR4, p-P65 and p-IκB and inhibited the translocation of P65 to nucleus in LPS-induced SiHa cells and Caski cells. These results indicated that CD200Fc appeared to suppress the inflammatory activity of TLR4-NF-κB and NLRP3 inflammasome pathway in LPS-induced SiHa cells and Caski cells. It provided novel mechanistic insights into the potential therapeutic uses of CD200Fc for cervical cancer.

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“…It is likely that these infections result in localized chronic inflammation that provides a suitable niche for persistent HPV infection ( Figure 5). A recent study evaluated association between bacterial vaginosis (BV) and inflammatory response (IR) with the severity of cervical neoplasia in HPVinfected women and have revealed vaginal infections irrespective of their nature (bacterial, fungal, yeast) increased the susceptibility, effects the clearance of HPV infection and eventually contributed towards HPVinduced cervical or genital carcinogenesis (38). These infections alter the microenvironment in the genital areas thereby causing severe inflammation, which en routes the development of cervical neoplasia.…”

Section: Spectrum Of Hpv-associated Diseases and Magnitude Of The Promentioning

confidence: 99%

Therapeutic startegies for human papillomavirus infection and associated cancers

et al. 2018

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Human papillomavirus (HPV) infection is linked to development of cancer of cervix, vagina, vulva, penis, ano-genital and non-genital oro-pharyngeal sites. HPV being a sexually transmitted virus infects both genders equally but with higher chances of pathological outcome in women. In the absence of organized screening programs, women report HPV-infected lesions at relatively advanced stages where they are subjected to standard treatments that are not HPV-specific. HPV infection-driven lesions usually take 10-20 years for malignant progression and are preceded by well-characterized pre-cancer stages. Despite availability of window for pharmacological intervention, therapeutic that could eradicate HPV from infected lesions is currently lacking. A variety of experimental approaches have been made to address this lacuna and there has been significant progress in a number of lead molecules which are in different stages of clinical and pre-clinical development. Present review provides a brief overview of the magnitude of the problem and current status of research on promising lead molecules, formulations and therapeutic strategies that showed potential to translate to clinically-viable HPV therapeutics to counteract this reproductive health challenge.

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Bacterial vaginosis and inflammatory response showed association with severity of cervical neoplasia in HPV‐positive women

Cited by 34 publications

References 47 publications

Self-Sampling for Human Papillomavirus Testing: Increased Cervical Cancer Screening Participation and Incorporation in International Screening Programs

Self-Sampling for Human Papillomavirus Testing: Increased Cervical Cancer Screening Participation and Incorporation in International Screening Programs

CD200Fc reduces LPS-induced IL-1β activation in human cervical cancer cells by modulating TLR4-NF-κB and NLRP3 inflammasome pathway

Therapeutic startegies for human papillomavirus infection and associated cancers

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