Bacterial Uropathogens in Urinary Tract Infection and Antibiotic Susceptibility Pattern in Jimma University Specialized Hospital, Southwest Ethiopia

Abstract

BackgroundUrinary tract infection (UTI) is one of the most common bacterial infections encountered by clinicians in developing countries. Area-specific monitoring studies aimed to gain knowledge about the type of pathogens responsible for urinary tract infections and their resistance patterns may help the clinician to choose the correct empirical treatment. Therefore, the aim of this study was to determine the type and antibiotic resistance pattern of the urinary pathogens isolated from patients attending Jimma University Specialized Hospital from April to June 2010.MethodsA hospital based cross sectional stud was conducted and urine samples were collected using the mid-stream “clean catch” method from 228 clinically-suspected cases of urinary tract infections and tested bacteriologically using standard procedures. Antimicrobial susceptibility test was performed for the isolated pathogens using Kirby-Bauer disk diffusion method according to Clinical and Laboratory Standards Institute guidelines.ResultsSignificant bacteria were detected from 9.2% of the total patients. The most common pathogens isolated were Escherichia coli (33.3%), Klebsiella pneumoniae (19%) and S. saprophyticus (14.3%). E. coli and Klebsiella pneumoniae showed the highest percentage of resistance to ampicillin and amoxacillin (100%) however, all isolates of E. coli and K. pneumoniae were susceptible to ciprofloxacin. S. saprophyticus and S. aureus were resistant to ampicillin (100%) and amoxicillin (66.7%). For all UTI isolates, least resistance was observed against drugs such as ceftriaxone, gentamycin and chloramphenicol.ConclusionThis study finding showed that E. coli isolates were the predominant pathogens and the presence of bacterial isolates with very high resistance to the commonly prescribed drugs that in turn leaves the clinicians with very few alternative options of drugs for the treatment of UTIs. As drug resistance among bacterial pathogens is an evolving process, routine surveillance and monitoring studies should be conducted to provide physicians knowledge on the updated and most effective empirical treatment of UTIs.

Urinary Tract Infection Treatment Pattern of Elderly Patients in a Tertiary Hospital Setup in South India: A Prospective Study

“…aspirin/naproxen with duloxetine) If not possible, then the dosing interval was changed (e.g. amitriptyline with duloxetine and linezolid combination)( Table 7, 8,9). The outcome of the most (68; 64.1%) of the patients showed were improved, followed by stable (26; 24.5%), died (5; 4.7%) and worsened control and monitoring of the chronic disease condition help in avoiding recurrence of UTIs.…”

“…8 Previous studies showed that increased mortality associated with bacterial infections, in older UTI patients was more and extensive need for prevention with early diagnosis of UTI is vital to reduce morbidity and mortality. 9 Antibiotics play a vital role in the treating of bacterial UTIs and in the majority of cases the initial empirical treatment is with broad spectrum antibiotics. 10 Unfortunately, this trend of antibiotic usage leads to antibiotic resistance, the emergence of multi-drug resistant (MDR) strains (Clostridium difficile infection) and adverse drug reactions (ADRs).…”

Antibiotic Susceptibility of Bacterial Strains Isolated From Urinary Tract Infections in Karaj, Iran

“…Urine samples were cultured on 5% blood agar, MacConkey, and Eosin-Methylene blue (EMB) agar (Oxoid Ltd, Bashingstore, Hampire, UK) using calibrated loops for semi-quantitative method (16) and incubated in both aerobic and anaerobic conditions for 24 hours at 37°C. Cultures without any colony at the end of 24h incubation were further incubated for 48h.…”

The Antibacterial Effects of Zno Nanoparticles on Patients with Urinary Tract Infection Isolated From Alzahra Hospital in Isfahan, Iran

“…In recent years, resistance to antibiotics is a great public health problems posed in the world, Resistance to antibiotics as a threat to human health, which is on the rise. Multi drugresistant E. coli infections increased annual and it is a serious problem [14,15]. that they are easy to synthesize by different of bacteria [16].…”