Bacterial Translocation Is Prolonged in Burned Mice Infected with Cytomegalovirus

Erickson, Evelyn; Saffle, Jeffrey R.; Morris, Stephen; Eichwald, E. J.; Sullivan, John J.; Shelby, Jane

doi:10.1097/00004630-199109000-00011

Cited by 4 publications

(2 citation statements)

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“…Animal experiments using burned mice clearly showed that an additional murine CMV (MCMV) infection significantly increased morbidity and mortality. In this context, Saffle and his group 27,28 have shown that MCMV-infected, thermally injured mice had a significant increased and prolonged bacterial translocation rate to mesenteric lymph nodes. Several murine studies demonstrate that infection with cytomegalovirus enhances susceptibility to secondary bacterial infection and increases mortality in these animals.…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus and Burns: Current Perceptions, Awareness, Diagnosis, and Management Strategies in the United States and Germany

Tenenhaus

Rennekampff

Pfau

et al. 2006

Journal of Burn Care & Research

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Trauma and immunosuppressed patients are at risk for cytomegalovirus (CMV) disease. Attributing pathogenicity in burn patients remains difficult and controversial because data are sparse. In this work, we surveyed U.S. and German burn centers and evaluated them for awareness, perceptions, diagnosis, and treatment of CMV in patients with burn injury. A total of 58% German (G) and 21% U.S. centers responded. CMV infection incidence was 1:280 G and 1:870 U.S. A total of 41% G and 78% U.S. burn centers considered CMV to be of minor importance and 41% G and 13% U.S. centers considered CMV to be of significant importance. A total of 70% G and 97% U.S. centers performed no admission screening. When testing, 70% G and 19% U.S. centers used serology; 52% G and 25% U.S. centers used body fluid viral isolation; and 43% G and 6% U.S. centers used leukocyte CMV-DNA analysis. A total of 72% G and 48% U.S. centers distinguished infection from disease. Human CMV disease was diagnosed by CMV-DNA (82% G, 19% U.S.), direct virus isolation (43% G, 13% U.S.), or RNA detection (26% G, 0% U.S.). A total of 43% G and 19% U.S. would treat the established disease. Establishing consistent guidelines for screening, diagnosis, and treatment seems prudent in caring for the immunocompromised burn patient.

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Section: Discussionmentioning

confidence: 99%

Cytomegalovirus and Burns: Current Perceptions, Awareness, Diagnosis, and Management Strategies in the United States and Germany

Tenenhaus

Rennekampff

Pfau

et al. 2006

Journal of Burn Care & Research

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“…Mehr als 50 % der teilnehmenden Zentren verabreichen bei seronegativen Patienten CMV-negative Blutprodukte ( In tierexperimentellen Untersuchungen konnte gezeigt werden, dass CMV-infizierte Mäuse eine erhöhte und prolongierte intestinale bakterielle Translokationsrate im Vergleich zu nicht infizierten Tieren aufwiesen [4]. Des weiteren konnten Kobayashi und Mitarb.…”

Section: Materials Und Methodenunclassified

Die Bedeutung der Cytomegalievirus-Infektion in deutschsprachigen Verbrennungszentren

Pfau

Hamprecht²,

Schaller³

et al. 2004

Handchir Mikrochir plast Chir

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Due to immunosuppression, burn patients are at risk for CMV-infection. By means of a retrospective questionnaire we evaluated the clinical rating and management of CMV-infection in German-speaking burn centers. 41 % of the participating burn centers considered the role of CMV-infection of overall minor importance, 41 % of importance only in intensive care burn patients, 18 % of overall great importance. 70 % of the participating burn centers do not perform CMV-screening at admission. More than 50 % of the participating burn centers consider application of CMV-negative human blood-derived products in CMV-seronegative individuals as essential. At present clinical importance of CMV-infection in burn patients can not be clearly determined. But further prospective studies utilizing recently developed diagnostics seem warranted to the potential influence of CMV-infection on morbidity and mortality in burn patients.

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Early But Not Late Burn Wound Excision Partially Restores Viral-Specific T Lymphocyte Cytotoxicity

Hultman

Yamamoto

deSerres

et al. 1997

The Journal of Trauma: Injury, Infection, and Critical Care

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Bacterial Translocation Is Prolonged in Burned Mice Infected with Cytomegalovirus

Cited by 4 publications

References 0 publications

Cytomegalovirus and Burns: Current Perceptions, Awareness, Diagnosis, and Management Strategies in the United States and Germany

Cytomegalovirus and Burns: Current Perceptions, Awareness, Diagnosis, and Management Strategies in the United States and Germany

Die Bedeutung der Cytomegalievirus-Infektion in deutschsprachigen Verbrennungszentren

Early But Not Late Burn Wound Excision Partially Restores Viral-Specific T Lymphocyte Cytotoxicity

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