Bacterial Translocation in Patients With Crohn's Disease Undergoing Surgery

Takesue, Yoshio; Ohge, Hiroki; Uemura, Kennichro; Imamura, Yuji; Murakami, Yoshiaki; Yokoyama, Takashi; Kakehashi, Masayuki; Sueda, Taijiro

doi:10.1007/s10350-004-7256-z

Cited by 47 publications

(42 citation statements)

References 25 publications

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“…BT occurred more frequently in patients who underwent emergency surgery and in those who received preoperative TPN. In contrast to reports published previously by both the authors and other investigators, there was no evidence to suggest an independent association between BT and age 8 , intestinal obstruction 3,11 , obstructive jaundice 6,12 , inflammatory bowel disease 13 or malignancy 14 . The reason for these differences is almost certainly a consequence of the fact that all previous studies based their conclusions exclusively on univariate analysis.…”

Section: Discussionmentioning

confidence: 79%

Bacterial translocation studied in 927 patients over 13 years

MacFie

Reddy

Gatt

et al. 2005

British Journal of Surgery

171

120

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Section: Discussionmentioning

confidence: 79%

Bacterial translocation studied in 927 patients over 13 years

MacFie

Reddy

Gatt

et al. 2005

British Journal of Surgery

171

120

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“…[69][70][71] Intestinal permeability is significantly increased in 36% of CD patients 72 and bacterial translocation of E. coli, Enterococcus spp., Clostridium perfringens has been observed in mesenteric nodes in 30-50% of CD patients versus 5-15% in healthy controls. 73,74 This could be due to: (1) bacterial uptake via Peyer's patches and (2) bacterial translocation due to abnormal tight junctions. Increased intestinal permeability has been shown in CD patients carrying NOD2 polymorphisms.…”

Section: Listeria Monocytogenes Bacteroides Vulgatus Bacteroides Burgmentioning

confidence: 99%

Immunopathogenesis of inflammatory bowel disease

Matricon¹,

Barnich²,

Ardid³

2010

Self/Nonself

190

137

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REVIEW Definition and EpidemiologyInflammatory bowel disease (IBD) is characterized by severe inflammation of the small bowel and/or the colon leading to recurrent diarrhea and abdominal pain. Crohn disease (CD) and ulcerative colitis (UC) are the two main clinicopathological subtypes of IBD. Despite both being chronic and relapsing inflammatory diseases of the bowel, they can be differentiated by the location of the inflammation in the gastrointestinal tract and by Inflammatory bowel disease (IBD) is a group of idiopathic, chronic and relapsing inflammatory conditions of the gastrointestinal tract. Familial and epidemiological studies have stressed the involvement of genetic factors and have also shown the critical role of environmental factors such as sanitation and hygiene in the development of IBD. However, the molecular mechanisms of intestinal inflammation in IBD have long remained unknown. In recent years, the study of susceptibility genes involved in the detection of bacterial components and in the regulation of the host immune response has shed light onto the potential role of intestinal pathogens and gut flora in IBD immunobiology. This review presents current knowledge on intestinal epithelial barrier alterations and on dysfunction of mucosal innate and acquired immune responses in IBD. The data support the etiological hypothesis which argues that pathogenic intestinal bacteria and/or infectious agents initiate and perpetuate the inflammation of the gut through disruption of tolerance towards the commensal microbiota in an individual with genetic vulnerability. Immunopathogenesis of inflammatory bowel disease

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“…Bacterial strains involved in translocation include E. coli, Enterococcus spp, Clostridium perfringens, Proteus spp and Bacteroides fragilis. Distension of the intestine proximal to a stricture may predispose to bacterial translocation [85,86] .…”

Section: The Excesssive Bacterial Translocation Theorymentioning

confidence: 99%