Bacterial toxins which perturb ciliary function and respiratory epithelium

Dowling,; Wilson, F. F.

doi:10.1046/j.1365-2672.1998.0840s1138s.x

Cited by 8 publications

(12 citation statements)

References 48 publications

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“…Cilia features that may contribute to lung disease include cilia function (ciliary beat frequency-CBF- and wave pattern), the length of the cilia, the ratio of ciliated to non-ciliated areas, cilia structure, and the susceptibility of the cilia to endogenous and exogenous factors that modify their CBF and quality of motion [11,13,18,20,22,24,48,49,50,51,52,53]. Random ciliary orientation has also been reported as a possible cause of respiratory disease [54,55].…”

Section: Airway Epithelium: a Specialized Physical Secretory Andmentioning

confidence: 99%

“…Numerous agents and drugs (Table 1) have been shown to modulate CBF [16,17] with efficient mucociliary transport relying on effective regulation of ciliary beating [11,22]. In vitro, beta-adrenergic and cholinergic agents were demonstrated to stimulate CBF, while fluticasone, some preservatives, anaesthetics, and some bacterial toxins inhibited CBF [16,17,18,19]. In addition, the effect of hyperosmolar agents on the muco-ciliary transport apparatus has been documented [38,75].…”

Section: What Modulates Airway Cilia Function?mentioning

confidence: 99%

“…Differences in CBF have been documented in diverse patient populations [7,122] and numerous drugs and excipients have been shown to affect CBF and mucociliary clearance (MCC) [16,107,108]. As mentioned earlier in this review, beta-adrenergic and cholinergic agents stimulate CBF, while fluticasone, some preservatives, and some bacterial toxins inhibit CBF [16,17,18,19,21,106,107]. However, we do not know the effect of exacerbations on CBF in epithelial cells of COPD patients.…”

Section: Factors That Can Affect Cbf In Copdmentioning

confidence: 99%

“…Many drugs and excipients have been shown to affect CBF and mucus clearance. Beta-adrenergic and cholinergic agents stimulate CBF, while fluticasone, some preservatives, and some bacterial toxins inhibit CBF [13,16,18,21,50,58,106,107,108]. …”

Section: Figurementioning

confidence: 99%

“…Structure-function studies have helped identify the ciliary targets that participate in regulating ciliary beating, however, our understanding of such regulation is far from complete [3,13,14,15]. Many endogenous and exogenous factors can influence cilia function [16,17,18,19,20,21] with efficient mucociliary transport relying on effective regulation of ciliary beating [11,22]. The ultrastructure of cilia is well documented [23,24].…”

Section: Introductionmentioning

confidence: 99%

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Airway Epithelial Cell Cilia and Obstructive Lung Disease

Yaghi

Dolovich

2016

Cells

123

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Airway epithelium is the first line of defense against exposure of the airway and lung to various inflammatory stimuli. Ciliary beating of airway epithelial cells constitutes an important part of the mucociliary transport apparatus. To be effective in transporting secretions out of the lung, the mucociliary transport apparatus must exhibit a cohesive beating of all ciliated epithelial cells that line the upper and lower respiratory tract. Cilia function can be modulated by exposures to endogenous and exogenous factors and by the viscosity of the mucus lining the epithelium. Cilia function is impaired in lung diseases such as COPD and asthma, and pharmacologic agents can modulate cilia function and mucus viscosity. Cilia beating is reduced in COPD, however, more research is needed to determine the structural-functional regulation of ciliary beating via all signaling pathways and how this might relate to the initiation or progression of obstructive lung diseases. Additionally, genotypes and how these can influence phenotypes and epithelial cell cilia function and structure should be taken into consideration in future investigations.

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Section: Airway Epithelium: a Specialized Physical Secretory Andmentioning

confidence: 99%

Section: What Modulates Airway Cilia Function?mentioning

confidence: 99%

Section: Factors That Can Affect Cbf In Copdmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Airway Epithelial Cell Cilia and Obstructive Lung Disease

Yaghi

Dolovich

2016

Cells

123

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BapC autotransporter protein of Bordetella pertussis is an adhesion factor

Bokhari

Bilal

Zafar

2011

J. Basic Microbiol.

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Bordetella pertussis, the causative agent of whooping cough, attaches to mucosal surfaces in upper respiratory tract, where it produces, a variety of surface-associated and secreted molecules. Among various secreted products, some of the proteins belonging to autotransporter family; pertactin (Prn), bordetella resistance to killing (BrkA) and a newly identified member, bordetella autotransporter protein-C (BapC), are investigated in this study for their adherence potential to various respiratory and non-respiratory tract specific cell lines. Our results reveal that BapC and Prn mutants adhere significantly less (p < 0.0001 and p < 0.05) respectively to human non-respiratory (HeLa-229) and murine macrophages (P-388 D-1) cells compared to their wild-type strains. Prn, BrkA and BapC share no homology in their passenger domains except existence of common motifs arginine-glycine-asparctic (RGD) and glycosaminoglycan binding site (SGXG). We have shown that RGD and SGXG motifs are present in the coiled region in Prn and BrkA proteins with the exception in BapC where R (463) of RGD and S (597) of SGXG motif were observed in beta sheet of the modeled protein structures. Therefore, there is possibility that such arrangement of motifs can confer greater probability of BapC in better selective adherence to binding sites on the HeLa-229 and P-388 D-1 cell lines.

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Primary Ciliary Dyskinesia (Immotile Cilia Syndrome—Kartagener Syndrome)

2005

Pediatric Pulmonology

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Bacterial toxins which perturb ciliary function and respiratory epithelium

Cited by 8 publications

References 48 publications

Airway Epithelial Cell Cilia and Obstructive Lung Disease

Airway Epithelial Cell Cilia and Obstructive Lung Disease

BapC autotransporter protein of Bordetella pertussis is an adhesion factor

Primary Ciliary Dyskinesia (Immotile Cilia Syndrome—Kartagener Syndrome)

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