Bacterial toxicity comparison between nano- and micro-scaled oxide particles

Jiang, Wei; Mashayekhi, Hamid; Xing, Baoshan

doi:10.1016/j.envpol.2008.12.025

Cited by 727 publications

(408 citation statements)

References 29 publications

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“…An antibacterial effect can also be due to the physical impact nanoparticles have on the cells (microabrasion, surface rigidification, bacterial flocculation) [76]. These effects do not rely on the chemical nature, and are thus expected to be of lower magnitude, on par with unreactive nanoparticulate systems (nanodiamonds, SiO 2 , Al 2 O 3 ) [77][78][79].…”

Section: Role Of the Nanoparticulate Objectsmentioning

confidence: 99%

Antibacterial activity of silver nanoparticles: A surface science insight

2015

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Summary Silver nanoparticles constitute a very promising approach for the development of new antimicrobial systems. Nanoparticulate objects can bring significant improvements in the antibacterial activity of this element, through specific effect such as an adsorption at bacterial surfaces. However, the mechanism of action is essentially driven by the oxidative dissolution of the nanoparticles, as indicated by recent direct observations. The role of Ag + release in the action mechanism was also indirectly observed in numerous studies, and explains the sensitivity of the antimicrobial activity to the presence of some chemical species, notably halides and sulfides which form insoluble salts with Ag + . As such, surface properties of Ag nanoparticles have a crucial impact on their potency, as they influence both physical (aggregation, affinity for bacterial membrane, etc.) and chemical (dissolution, passivation, etc.) phenomena. Here, we review the main parameters that will affect the surface state of Ag NPs and their influence on antimicrobial efficacy. We also provide an analysis of several works on Ag NPs activity, observed through the scope of an oxidative Ag + release.

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Section: Role Of the Nanoparticulate Objectsmentioning

confidence: 99%

Antibacterial activity of silver nanoparticles: A surface science insight

2015

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“…After BSA/HA treatment, the Al 2 O 3 NPs obviously show better dispersion when compared with the untreated NPs, but the SiO 2 NPs look very similar to the untreated NPs. The TiO 2 NPs were reported as tending to form large and compact agglomerates (Jiang et al, 2009;Keller et al, 2010). BSA treatments make TiO 2 NPs less compact and the BSA coatings on the NPs agglomerates can be observed, but HA induces more compact agglomerates.…”

Section: Effects Of Bsa and Ha On Nps Agglomeration Observed By Tem Imentioning

confidence: 99%

Effects of humic acid and bovine serum albumin on the agglomeration and sedimentation of oxide nanoparticles

Lin

Chen

et al. 2014

J. Zhejiang Univ. Sci. A

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Abstract:To better understand the nanoparticle (NP) transport in the environment, the agglomeration and sedimentation of Al 2 O 3 , SiO 2 , and TiO 2 NPs were evaluated after being treated with bovine serum albumin (BSA) and a commercial humic acid (HA). The morphology of NP agglomerates was examined through a transmission electron microscope (TEM), and the agglomeration kinetics was evaluated using established time-resolved dynamic light scattering techniques. BSA treatments decreased the hydrodynamic diameters (d H ) of the three NPs in both NaCl and CaCl 2 electrolytes due to their steric repulsive forces caused by the BSA globular architecture. The treatments using HA induced the smallest d H of NPs in NaCl electrolyte, but the largest d H of NPs was found in CaCl 2 electrolyte, because the HA bound to each other via calcium complexation and thereby enhanced the NP agglomeration. The zeta potentials of NPs were not the dominant factor to affect agglomeration. The NP sedimentation kinetics were studied through measuring the suspension optical absorbance. It was shown that the BSA treatments retarded the sedimentation in most situations; however, HA treatments accelerated the sedimentation greatly in CaCl 2 electrolyte, which was consistent with the measured changes in the d H values. The smallest d H of HA-treated NPs in NaCl electrolyte did not result in the lowest sedimentation rate, which indicated that the agglomeration size was not the only factor to affect the NP sedimentation.

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“…The harmful effects of ZnONPs are driven by their physicochemical properties (dissolution and formation rate, the morphology and chemical composition, surface reactivity, particle number) and the resulting physical damage caused by the aggregation and agglomeration of nanoparticles (Bai et al, 2010;Jiang et al, 2009;Zhang et al, 2010. The bio-kinetic behaviour and in vivo toxicity of ZnONP exposure has, to date, been investigated in several non-mammalian systems including in vitro cell-based assays (Sharma et al, 2012a,b;Ahamed et al, 2011;Wu et al, 2010), bacteria (Li et al, 2011;Reddy et al, 2007), algae (Franklin et al, 2007), plants (Lin and Xing, 2007), crustaceans (Poynton et al, 2011), fish (Bai et al, 2010), earthworms (Hooper et al, 2011) and nematodes (Khare et al, 2011;Ma et al, 2009;Ma et al, 2011;Roh et al, 2009;Wu et al, 2013). The nematode Caenorhabditis elegans, a powerful model organism due to the availability of a completely sequenced genome (Hillier et al, 2005) and many molecular genetics tools has been used in ecotoxicological research to study the molecular to organismal level responses to ROS and heavy metal challenges (Roh et al, 2006;Hughes and Sturzenbaum 2007;Swain et al, 2004Swain et al, , 2010Zeitoun-Ghandour et al, 2010; The roles of the metalloproteins metallothionein (MT) and phytochelatin (PC) are Furthermore, ZnONP mediated toxicity may result from the release of free ionic zinc (George et al 2010;Li et al, 2012;Poynton et al, 2011;Wang et al, 2009), which induces cellular damage via the generation of free reactive oxygen species (ROS), which in turn can promote pro-inflammatory effects Mocchegiani et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Metalloproteins and phytochelatin synthase may confer protection against zinc oxide nanoparticle induced toxicity in Caenorhabditis elegans

Polak

Read

Jurkschat

et al. 2014

Comparative Biochemistry and Physiology Part C: Toxicology &

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Spurgeon, David J.; Sturzenbaum, Stephen R.. 2014. Metalloproteins and phytochelatin synthase may confer protection against zinc oxide nanoparticle induced toxicity in Caenorhabditis elegansContact CEH NORA team at noraceh@ceh.ac.ukThe NERC and CEH trademarks and logos ('the Trademarks') are registered trademarks of NERC in the UK and other countries, and may not be used without the prior written consent of the Trademark owner. suggesting that the nominal exposure to pure ZnONPs represents in vivo, at best, a mixture exposure of ionic zinc and nanoparticles. Nevertheless, the analyzes provided evidence that the metallothioneins (mtl-1 and mtl-2), the pytochelatin synthase (pcs-1) and an apoptotic marker (cep-1) were transcriptionally activated. In addition, the DCFH-DA assay provided in vitro evidence of the oxidative potential of ZnONPs in the metal exposure sensitive triple mutant.Raman spectroscopy highlighted that the biomolecular phenotype changes significantly in the metal sensitive knockout worm upon ZnONP exposure, suggesting that these metalloproteins are instrumental in the protection against cytotoxic damage. Finally, ZnONP exposure was shown to decrease growth and development, reproductive capacity and lifespan, effects which were amplified in the triple knockout. By combining diverse toxicological strategies, we identified that individuals (genotypes) housing mutations in key metalloproteins are more susceptible to ZnONP exposure, which underlines the importance of fully functional metalloproteins to minimize ZnONP induced toxicity.

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Bacterial toxicity comparison between nano- and micro-scaled oxide particles

Cited by 727 publications

References 29 publications

Antibacterial activity of silver nanoparticles: A surface science insight

Antibacterial activity of silver nanoparticles: A surface science insight

Effects of humic acid and bovine serum albumin on the agglomeration and sedimentation of oxide nanoparticles

Metalloproteins and phytochelatin synthase may confer protection against zinc oxide nanoparticle induced toxicity in Caenorhabditis elegans

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