1990
DOI: 10.1128/cmr.3.2.99
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Bacterial spores and chemical sporicidal agents

Abstract: Bacterial spores are among the most resistant of all living cells to biocides, although the response depends on the stage of sporulation. The development of resistance to some agents such as chlorhexidine occurs much earlier in sporulation than does resistance to glutaraldehyde, which is a very late event. During germination or outgrowth or both, resistance is lost and the cells become as susceptible to biocides as nonsporulating bacteria. Mechanisms of spore resistance to, and the action of, biocides are disc… Show more

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Cited by 320 publications
(275 citation statements)
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References 181 publications
(234 reference statements)
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“…Although this study did not attempt to quantify the effects the food residues on sporicidal efficacy, future work in this area may be quite useful. The observation that log 10 CFU reductions tended to increase approximately twofold with each 10°C rise in treatment temperature is consistent with other reports (14) and may have some practical value when decontamination guidance documents are created. Given the relatively high concentrations of peroxyacetic acid and hydrogen peroxide needed for significant inactivation at 10 to 30°C, additional studies with higher temperatures and longer exposure times may also prove useful.…”
Section: Discussionsupporting
confidence: 76%
“…Although this study did not attempt to quantify the effects the food residues on sporicidal efficacy, future work in this area may be quite useful. The observation that log 10 CFU reductions tended to increase approximately twofold with each 10°C rise in treatment temperature is consistent with other reports (14) and may have some practical value when decontamination guidance documents are created. Given the relatively high concentrations of peroxyacetic acid and hydrogen peroxide needed for significant inactivation at 10 to 30°C, additional studies with higher temperatures and longer exposure times may also prove useful.…”
Section: Discussionsupporting
confidence: 76%
“…Dormant bacterial endospores are much more resistant than their growing cell counterparts to common sterilization and disinfection treatments, including heat, radiation and various chemicals (Roberts and Hitchins 1969;Russell 1990;Bloomfield and Arthur 1994;McDonnell and Russell 1999;Setlow 2000). Many factors are involved in spore resistance properties, including the relative impermeability of the spore core, the low water content and high levels of pyridine-2,6-dicarboxylic acid (dipicolinic acid (DPA)) and divalent cations in the spore core, and the thick outer proteinaceous coat; the importance of these various factors varies depending on the particular resistance property examined (Gerhardt and Marquis 1989;Setlow 1994;Setlow 2000).…”
Section: Introductionmentioning
confidence: 99%
“…This spore is the most resistant form of the microbe. Bacterial spores are among the most resistant of all living cells to biocides [8].…”
Section: Discussionmentioning
confidence: 99%