Bacterial Specificity in the Etiology of Caries and Periodontal Disease

Kestenbaum, R.C.

doi:10.1177/00220345680470065501

J Dent Res

1968

DOI: 10.1177/00220345680470065501

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Bacterial Specificity in the Etiology of Caries and Periodontal Disease

R.C. Kestenbaum¹

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“…treptococcus mutans is a principal etiological agent of dental caries (1,2). Among all the physiological traits, three play crucial roles in S. mutans pathogenicity.…”

mentioning

confidence: 99%

SMU.746-SMU.747, a Putative Membrane Permease Complex, Is Involved in Aciduricity, Acidogenesis, and Biofilm Formation in Streptococcus mutans

Król

Biswas

King

et al. 2013

Journal of Bacteriology

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Dental caries induced by Streptococcus mutans is one of the most prevalent chronic infectious diseases worldwide. The pathogenicity of S. mutans relies on the bacterium's ability to colonize tooth surfaces and survive a strongly acidic environment. We performed an ISS1 transposon mutagenesis to screen for acid-sensitive mutants of S. mutans and identified an SMU.746-SMU.747 gene cluster that is needed for aciduricity. SMU.746 and SMU.747 appear to be organized in an operon and encode a putative membrane-associated permease. SMU.746-and SMU.747-deficient mutants showed a reduced ability to grow in acidified medium. However, the short-term or long-term acid survival capacity and F 1 F 0 ATPase activity remained unaffected in the mutants. Furthermore, deletion of both genes did not change cell membrane permeability and the oxidative and heat stress responses. Growth was severely affected even with slight acidification of the defined medium (pH 6.5). The ability of the mutant strain to acidify the defined medium during growth in the presence of glucose and sucrose was significantly reduced, although the glycolysis rate was only slightly affected. Surprisingly, deletion of the SMU.746-SMU.747 genes triggered increased biofilm formation in low-pH medium. The observed effects were more striking in a chemically defined medium. We speculate that the SMU.746-SMU.747 complex is responsible for amino acid transport, and we discuss its possible role in colonization and survival in the oral environment.

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“…treptococcus mutans is a principal etiological agent of dental caries (1,2). Among all the physiological traits, three play crucial roles in S. mutans pathogenicity.…”

mentioning

confidence: 99%

SMU.746-SMU.747, a Putative Membrane Permease Complex, Is Involved in Aciduricity, Acidogenesis, and Biofilm Formation in Streptococcus mutans

Król

Biswas

King

et al. 2013

Journal of Bacteriology

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Dental Plaque and Dietary Intakes in Schoolchildren in Hawaii

et al. 1977

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Plaque formation on the teeth as measured by the number of teeth with a heavy plaque accumulation was found to be influenced by diet. Accumulation of plaque was enhanced by the frequent consumption of food items such as sweet rolls, sweet breads, manapua, and poi. All of these are characterized by their sucrose content and stickiness. However, fruit drinks were shown to have a retarding effect on plaque growth. The information on the amount of plaque had little relationship with the dental caries status of the subjects, whereas it was significantly associated with periodontal health.

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Bacterial Specificity in the Etiology of Caries and Periodontal Disease

Cited by 2 publications

References 0 publications

SMU.746-SMU.747, a Putative Membrane Permease Complex, Is Involved in Aciduricity, Acidogenesis, and Biofilm Formation in Streptococcus mutans

SMU.746-SMU.747, a Putative Membrane Permease Complex, Is Involved in Aciduricity, Acidogenesis, and Biofilm Formation in Streptococcus mutans

Dental Plaque and Dietary Intakes in Schoolchildren in Hawaii

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