Bacterial secretion system functions: evidence of interactions and downstream implications

Maphosa, Silindile; Moleleki, Lucy N.; Motaung, Thabiso E.

doi:10.1099/mic.0.001326

Cited by 9 publications

(3 citation statements)

References 133 publications

(225 reference statements)

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“…Molecular effector secretion by microbial pathogens involves sophisticated mechanisms for manipulating host cellular processes. Pathogens utilize various secretion systems, including T3SS, T4SS, T6SS, outer membrane vesicles (OMVs), and direct secretion systems to deliver effector proteins into host cells (Chalupowicz et al, 2023 ; De Ryck et al, 2023 ; De Sousa et al, 2023 ; Maphosa et al, 2023 ; Wangthaisong et al, 2023 ). These effectors manipulate the host cellular processes to promote infection and pathogenesis.…”

Section: Molecular Mechanisms Underlying Plant-microbe Interactionsmentioning

confidence: 99%

Omics approaches in understanding the benefits of plant-microbe interactions

Jain,

Sarsaiya,

Singh

et al. 2024

Front. Microbiol.

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Plant-microbe interactions are pivotal for ecosystem dynamics and sustainable agriculture, and are influenced by various factors, such as host characteristics, environmental conditions, and human activities. Omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, have revolutionized our understanding of these interactions. Genomics elucidates key genes, transcriptomics reveals gene expression dynamics, proteomics identifies essential proteins, and metabolomics profiles small molecules, thereby offering a holistic perspective. This review synthesizes diverse microbial-plant interactions, showcasing the application of omics in understanding mechanisms, such as nitrogen fixation, systemic resistance induction, mycorrhizal association, and pathogen-host interactions. Despite the challenges of data integration and ethical considerations, omics approaches promise advancements in precision intervention and resilient agricultural practices. Future research should address data integration challenges, enhance omics technology resolution, explore epigenomics, and understand plant-microbe dynamics under diverse conditions. In conclusion, omics technologies hold immense promise for optimizing agricultural strategies and fortifying resilient plant-microbe alliances, paving the way for sustainable agriculture and environmental stewardship.

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Section: Molecular Mechanisms Underlying Plant-microbe Interactionsmentioning

confidence: 99%

Omics approaches in understanding the benefits of plant-microbe interactions

Jain,

Sarsaiya,

Singh

et al. 2024

Front. Microbiol.

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“…Confronted with fluctuations in micronutrient levels, the elderly frequently resort to the consumption of dietary supplements as a strategic intervention to mitigate the impact of these alterations, introducing an additional determinant in the multifaceted interplay of factors influencing their health. Dietary supplements, typically derived from a myriad phytonutrients or fungal sources, while mandated to adhere to certain legal stipulations, are not held to the same rigorous regulatory standards as pharmaceutical medications [218,219]. Consequently, ensuring the prudent consumption of these supplements necessitates guidance from healthcare professionals who can assess and advise on potential interactions, a particularly imperative consideration for elderly consumers given their distinct physiological dynamics and potential susceptibility to complications.…”

Section: Overviewmentioning

confidence: 99%

An Update on Drug–Nutrient Interactions and Dental Decay in Older Adults

Bell,

Rodrigues,

Antoniadou

et al. 2023

Nutrients

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In recent decades, the global demographic landscape has undergone a discernible shift that has been characterised by a progressive increase in the proportion of elderly individuals, indicative of an enduring global inclination toward extended lifespans. The aging process, accompanied by physiological changes and dietary patterns, contributes to detrimental deviations in micronutrient consumption. This vulnerable aging population faces heightened risks, including dental caries, due to structural and functional modifications resulting from insufficient nutritional sustenance. Factors such as physiological changes, inadequate nutrition, and the prevalence of multiple chronic pathologies leading to polypharmacy contribute to the challenge of maintaining an optimal nutritional status. This scenario increases the likelihood of drug interactions, both between medications and with nutrients and the microbiome, triggering complications such as dental decay and other pathologies. Since the drug industry is evolving and new types of food, supplements, and nutrients are being designed, there is a need for further research on the mechanisms by which drugs interfere with certain nutrients that affect homeostasis, exemplified by the prevalence of caries in the mouths of older adults. Infectious diseases, among them dental caries, exert serious impacts on the health and overall quality of life of the elderly demographic. This comprehensive review endeavours to elucidate the intricate interplay among drugs, nutrients, the microbiome, and the oral cavity environment, with the overarching objective of mitigating the potential hazards posed to both the general health and dental well-being of older adults. By scrutinising and optimising these multifaceted interactions, this examination aims to proactively minimise the susceptibility of the elderly population to a spectrum of health-related issues and the consequences associated with dental decay.

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“…Because of this antagonism, VirB/D4 has almost zero retention value in the presence of BadA, and most human B. henselae isolates are lost to either BadA or VirB/D4. Overall, the interaction of the BadA and VirB/D-like complexes in B. henselae reveals a possible antagonistic relationship between T4SS and T5SS that may influence pathogen virulence and infectivity [ 95 , 96 ].…”

Section: The Love and Hate Relationshipmentioning

confidence: 99%

The Love and Hate Relationship between T5SS and Other Secretion Systems in Bacteria

Luo,

Chen,

Lian

et al. 2023

IJMS

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Bacteria have existed on Earth for billions of years, exhibiting ubiquity and involvement in various biological activities. To ensure survival, bacteria usually release and secrete effector proteins to acquire nutrients and compete with other microorganisms for living space during long-term evolution. Consequently, bacteria have developed a range of secretion systems, which are complex macromolecular transport machines responsible for transporting proteins across the bacterial cell membranes. Among them, one particular secretion system that stands out from the rest is the type V secretion system (T5SS), known as the “autotransporter”. Bacterial activities mediated by T5SS include adherence to host cells or the extracellular matrix, invasion of host cells, immune evasion and serum resistance, contact-dependent growth inhibition, cytotoxicity, intracellular flow, protease activity, autoaggregation, and biofilm formation. In a bacterial body, it is not enough to rely on T5SS alone; in most cases, T5SS cooperates with other secretion systems to carry out bacterial life activities, but regardless of how good the relationship is, there is friction between the secretion systems. T5SS and T1SS/T2SS/T3SS/T6SS all play a synergistic role in the pathogenic processes of bacteria, such as nutrient acquisition, pathogenicity enhancement, and immune modulation, but T5SS indirectly inhibits the function of T4SS. This could be considered a love–hate relationship between secretion systems. This paper uses the systematic literature review methodology to review 117 journal articles published within the period from 1995 to 2024, which are all available from the PubMed, Web of Science, and Scopus databases and aim to elucidate the link between T5SS and other secretion systems, providing clues for future prevention and control of bacterial diseases.

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Bacterial secretion system functions: evidence of interactions and downstream implications

Cited by 9 publications

References 133 publications

Omics approaches in understanding the benefits of plant-microbe interactions

Omics approaches in understanding the benefits of plant-microbe interactions

An Update on Drug–Nutrient Interactions and Dental Decay in Older Adults

The Love and Hate Relationship between T5SS and Other Secretion Systems in Bacteria

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