Bacterial ratchet motors

Leonardo, R. Di; Angelani, L.; Dell'Arciprete, Dario; Ruocco, G.; Iebba, Valerio; Schippa, Serena; Conte, Miriam; Mecarini, Federico; Angelis, Francesco De; Fabrizio, E. Di

doi:10.1073/pnas.0910426107

Cited by 621 publications

(487 citation statements)

References 22 publications

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“…However, nature has its own solutions since billions of years ago: flagellated swimming bacteria can efficiently convert chemical energy into mechanical actuation with their nanoscale biomotors. Over the past decade, numerous studies have been conducted on harnessing the flagellated bacteria, such as E. coli and S. marcescens , as propellers for biohybrid microswimmers,1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 aiming to develop a new type of targeted drug delivery system for tumor therapy 14, 16, 18, 19. Recently, efforts have also been made to guide the motion of such bacteria‐driven microswimmers through taxis‐based14, 17, 20, 21, 22, 23, 24, 25 and magnetic steering16, 26 approaches.…”

Section: Introductionmentioning

confidence: 99%

Propulsion and Chemotaxis in Bacteria‐Driven Microswimmers

2017

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Despite the large body of experimental work recently on biohybrid microsystems, few studies have focused on theoretical modeling of such systems, which is essential to understand their underlying functioning mechanisms and hence design them optimally for a given application task. Therefore, this study focuses on developing a mathematical model to describe the 3D motion and chemotaxis of a type of widely studied biohybrid microswimmer, where spherical microbeads are driven by multiple attached bacteria. The model is developed based on the biophysical observations of the experimental system and is validated by comparing the model simulation with experimental 3D swimming trajectories and other motility characteristics, including mean squared displacement, speed, diffusivity, and turn angle. The chemotaxis modeling results of the microswimmers also agree well with the experiments, where a collective chemotactic behavior among multiple bacteria is observed. The simulation result implies that such collective chemotaxis behavior is due to a synchronized signaling pathway across the bacteria attached to the same microswimmer. Furthermore, the dependencies of the motility and chemotaxis of the microswimmers on certain system parameters, such as the chemoattractant concentration gradient, swimmer body size, and number of attached bacteria, toward an optimized design of such biohybrid system are studied. The optimized microswimmers would be used in targeted cargo, e.g., drug, imaging agent, gene, and RNA, transport and delivery inside the stagnant or low‐velocity fluids of the human body as one of their potential biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Propulsion and Chemotaxis in Bacteria‐Driven Microswimmers

2017

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“…This effect has been used to direct bacterial motion [50] and harness bacterial power to propel microscopic gears [51][52][53]. However, optimizing such devices for technological applications requires understanding the interaction of an active fluid with boundaries of arbitrary shape.…”

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confidence: 99%

Dynamics of self-propelled particles under strong confinement

2014

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We develop a statistical theory for the dynamics of non-aligning, non-interacting self-propelled particles confined in a convex box in two dimensions. We find that when the size of the box is small compared to the persistence length of a particle's trajectory (strong confinement), the steady-state density is zero in the bulk and proportional to the local curvature on the boundary. Conversely, the theory may be used to construct the box shape that yields any desired density distribution on the boundary. When the curvature variations are small, we also predict the distribution of orientations at the boundary and the exponential decay of pressure as a function of box size recently observed in 3D simulations in a spherical box.Active fluids consisting of self-propelled units are found in biology on scales ranging from the dynamically reconfigurable cell cytoskeleton [1] to swarming bacterial colonies [2,3], healing tissues [4,5], and flocking animals [6]. Experiments have begun to achieve the extraordinary capabilities and emergent properties of these biological systems in nonliving active fluids of self-propelled particles, consisting of chemically [7][8][9][10][11][12] or electrically [13] propelled colloids, or monolayers of vibrated granular particles [14][15][16].In contrast to thermal motion, active motion is correlated over experimentally accessible time and length scales. When the persistence length of active motion becomes comparable to the mean free path, uniquely active effects arise that transcend the thermodynamically allowed behaviors of equilibrium systems, including giant number fluctuations and spontaneous flow [3,14,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. Importantly, a sufficient active persistence length is the only requirement for macroscopic manifestations of activity, as revealed by athermal phase separation of nonaligning, repulsive self-propelled particles [31][32][33][34][35][36][37][38][39][40][41].When boundaries and obstacles are patterned on the scale of the active correlation length, they dramatically alter the dynamics of the system, and striking macroscopic properties emerge [42][43][44][45][46][47][48][49]; for example, ratchets and funnels drive spontaneous flow in active fluids [42][43][44][45][46]. This effect has been used to direct bacterial motion [50] and harness bacterial power to propel microscopic gears [51][52][53]. However, optimizing such devices for technological applications requires understanding the interaction of an active fluid with boundaries of arbitrary shape. More generally, any real-world device necessarily includes boundaries, and thus the effects of boundary size and shape are essential design parameters. Although recent studies have explored confinement in simple geometries [43,47,[54][55][56], there is no general theory for the effect of boundary shape.In this Letter, we study the dynamics of non-aligning and non-interacting self-propelled particles confined to two-dimensional convex containers, such as ellipses and polygons. We find...

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“…Active matter exhibits a wealth of non-equilibrium effects observed in nature as well as synthetic systems: pattern formation [12,13], enhanced mixing [14,15] or sensing and interaction with the environment. For example, Escherichia coli bacteria were shown to concentrate owing to the presence of microfluidic funnels [16], rotate microscopic gears [17,18] or self-propelled nanorods are captured by passive spheres, stressing the importance of activity-driven interactions [19]. From a fundamental standpoint, they allow for the development of a theoretical framework for non-equilibrium statistical mechanics [20].…”

Section: Introductionmentioning

confidence: 99%

Light-activated self-propelled colloids

Palacci

Sacanna

Kim

et al. 2014

Phil. Trans. R. Soc. A.

128

133

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Light-activated self-propelled colloids are synthesized and their active motion is studied using optical microscopy. We propose a versatile route using different photoactive materials, and demonstrate a multiwavelength activation and propulsion. Thanks to the photoelectrochemical properties of two semiconductor materials (α-Fe 2 O 3 and TiO 2 ), a light with an energy higher than the bandgap triggers the reaction of decomposition of hydrogen peroxide and produces a chemical cloud around the particle. It induces a phoretic attraction with neighbouring colloids as well as an osmotic selfpropulsion of the particle on the substrate. We use these mechanisms to form colloidal cargos as well as self-propelled particles where the light-activated component is embedded into a dielectric sphere. The particles are self-propelled along a direction otherwise randomized by thermal fluctuations, and exhibit a persistent random walk. For sufficient surface density, the particles spontaneously form 'living crystals' which are mobile, break apart and reform. Steering the particle with an external magnetic field, we show that the formation of the dense phase results from the collisions heads-on of the particles. This effect is intrinsically non-equilibrium and a novel principle of organization for systems without detailed balance. Engineering families of particles self-propelled by different wavelength demonstrate a good understanding of both the physics and the chemistry behind the system and points to a general route for designing new families of self-propelled particles.

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Bacterial ratchet motors

Cited by 621 publications

References 22 publications

Propulsion and Chemotaxis in Bacteria‐Driven Microswimmers

Propulsion and Chemotaxis in Bacteria‐Driven Microswimmers

Dynamics of self-propelled particles under strong confinement

Light-activated self-propelled colloids

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